Mitochondrial DNA copy number in peripheral blood is independently associated with visceral fat accumulation in healthy young adults

International Journal of Endocrinology

Volumn 2014, Issue , 2014, Pages

  Lee, Jee Yon ^a   Lee, Duk Chul ^a   Im, Jee Aee ^b   Lee, Ji Won ^a  

^a Yonsei University College of Medicine   (South Korea)

^b INTOTO Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MITOCHONDRIAL DNA;

ABDOMINAL OBESITY; ADULT; ARTICLE; BODY MASS; COMPUTER ASSISTED TOMOGRAPHY; CROSS-SECTIONAL STUDY; FEMALE; GENE DOSAGE; HUMAN; HUMAN CELL; INTRAABDOMINAL FAT; LEUKOCYTE; MALE; NORMAL HUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; SOUTH KOREA; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 84897864864     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2014/586017     Document Type: Article

References (36)

1. Feinleib M., Epidemiology of obesity in relation to health hazards. Annals of Internal Medicine 1985 103 6, part 2 1019 1024 2-s2.0-0022340780 (Pubitemid 16211924)
2. Bray G. A., Medical consequences of obesity. Journal of Clinical Endocrinology and Metabolism 2004 89 6 2583 2589 2-s2.0-2942657650 10.1210/jc.2004-0535 (Pubitemid 38766335)
3. Tchernof A., Després J. P., Pathophysiology of human visceral obesity: an update. Physiological Reviews 2013 93 1 359 404
4. Ibrahim M. M., Subcutaneous and visceral adipose tissue: structural and functional differences. Obesity Reviews 2010 11 1 11 18 2-s2.0-74049159942 10.1111/j.1467-789X.2009.00623.x
5. Abate N., Garg A., Peshock R. M., Stray-Gundersen J., Grundy S. M., Relationships of generalized and regional adiposity to insulin sensitivity in men. The Journal of Clinical Investigation 1995 96 1 88 98 2-s2.0-0029087640
6. Despres J.-P., Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 1993 9 5 452 459 2-s2.0-0027496056 (Pubitemid 23332535)
7. Wajchenberg B. L., Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocrine Reviews 2000 21 6 697 738 2-s2.0-0034504237 10.1210/er.21.6.697 (Pubitemid 32113289)
8. Brehm A., Krssak M., Schmid A. I., Nowotny P., Waldhäusl W., Roden M., Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes 2006 55 1 136 140 2-s2.0-33644746318 10.2337/diabetes.55.1.136 (Pubitemid 43343308)
9. Johannsen D. L., Ravussin E., The role of mitochondria in health and disease. Current Opinion in Pharmacology 2009 9 6 780 786 2-s2.0-70449484092 10.1016/j.coph.2009.09.002
10. Larsson N., Clayton D. A., Molecular genetic aspects of human mitochondrial disorders. Annual Review of Genetics 1995 29 151 178 2-s2.0-0029587469 (Pubitemid 26005340)
11. Liu C., Tsai C., Kuo C., Chen H., Lii C., Ma Y., Wei Y., Oxidative stress-related alteration of the copy number of mitochondrial DNA in human leukocytes. Free Radical Research 2003 37 12 1307 1317 2-s2.0-0344012654 10.1080/10715760310001621342 (Pubitemid 37441714)
12. Clay Montier L. L., Deng J. J., Bai Y., Number matters: control of mammalian mitochondrial DNA copy number. Journal of Genetics and Genomics 2009 36 3 125 131 2-s2.0-62149086299 10.1016/S1673-8527(08)60099-5
13. Lee H. K., Song J. H., Shin C. S., Park D. J., Park K. S., Lee K. U., Koh C.-S., Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Research and Clinical Practice 1998 42 3 161 167 2-s2.0-0032429843 10.1016/S0168-8227(98) 00110-7 (Pubitemid 29009776)
14. Lee J., Park K. D., Im J., Kim M. Y., Lee D., Mitochondrial DNA copy number in peripheral blood is associated with cognitive function in apparently healthy elderly women. Clinica Chimica Acta 2010 411 7-8 592 596 2-s2.0-77649191873 10.1016/j.cca.2010.01.024
15. Kim J. H., Im J. A., Lee D. C., The relationship between leukocyte mitochondrial DNA contents and metabolic syndrome in postmenopausal women. Menopause 2012 19 5 582 587
16. Fontana L., Eagon J. C., Trujillo M. E., Scherer P. E., Klein S., Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007 56 4 1010 1013 2-s2.0-34047155003 10.2337/db06-1656 (Pubitemid 46525079)
17. Heilbronn L. K., Seng K. G., Turner N., Campbell L. V., Chisholm D. J., Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects. Journal of Clinical Endocrinology and Metabolism 2007 92 4 1467 1473 2-s2.0-34147175161 10.1210/jc.2006-2210 (Pubitemid 46556427)
18. Song J., Oh J. Y., Sung Y. H., Pak Y. K., Park K. S., Lee H. K., Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients. Diabetes Care 2001 24 5 865 869 2-s2.0-0035344913 (Pubitemid 33636060)
19. Lindinger A., Peterli R., Peters T., Kern B., Von Flüe M., Calame M., Hoch M., Eberle A. N., Lindinger P. W., Mitochondrial DNA content in human omental adipose tissue. Obesity Surgery 2010 20 1 84 92 2-s2.0-73949159131 10.1007/s11695-009-9987-3
20. Lee J. Y., Lee H. K., Lee D. C., Lee J. W., Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers. PloS ONE 2012 7 8 e43518
21. Lee J., Lee H., Shim J., Im J., Kim S., Choi H., Lee D., Viscerally obese women with normal body weight have greater brachial-ankle pulse wave velocity than nonviscerally obese women with excessive body weight. Clinical Endocrinology 2007 66 4 572 578 2-s2.0-33947210896 10.1111/j.1365-2265.2007. 02780.x (Pubitemid 46434946)
22. Wong A., Cortopassi G., Reproducible quantitative PCR of mitochondrial and nuclear DNA copy number using the LightCycler. Methods in Molecular Biology 2002 197 129 138 2-s2.0-0036361362
23. Higuchi R., Fockler C., Dollinger G., Watson R., Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Bio/Technology 1993 11 9 1026 1030 2-s2.0-0027291595 10.1038/nbt0993-1026 (Pubitemid 23254023)
24. Lee H., Lu C., Fahn H., Wei Y., Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Letters 1998 441 2 292 296 2-s2.0-0032429396 10.1016/S0014-5793(98)01564-6 (Pubitemid 29027913)
25. Patti M., Corvera S., The role of mitochondria in the pathogenesis of type 2 diabetes. Endocrine Reviews 2010 31 3 364 395 2-s2.0-77954859197 10.1210/er.2009-0027
26. Eun H. K., Park J., Park H., Min J. J., Je W. R., Kim M., Sun Y. K., Kim M., Kim S., In S. P., Jang H. Y., Lee K., Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes 2007 56 12 2973 2981 2-s2.0-36849085935 10.2337/db07-0510 (Pubitemid 350223632)
27. Kraunsøe R., Boushel R., Hansen C. N., Schjerling P., Qvortrup K., Støckel M., Mikines K. J., Dela F., Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. The Journal of Physiology 2010 588 12 2023 2032 2-s2.0-77954645400 10.1113/jphysiol.2009.184754
28. Wlodek D., Gonzales M., Decreased energy levels can cause and sustain obesity. Journal of Theoretical Biology 2003 225 1 33 44 2-s2.0-0141961773 10.1016/S0022-5193(03)00218-2 (Pubitemid 37237610)
29. Yin X., Lanza I. R., Swain J. M., Sarr M. G., Nair K. S., Jensen M. D., Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size. Journal of Clinical Endocrinology & Metabolism 2013 10.1210/jc.2013-3042
30. Park K. S., Lee K., Song J. H., Choi C. S., Shin C. S., Park D. J., Kim S. K., Koh J. J., Lee H. K., Peripheral blood mitochondrial DNA content is inversely correlated with insulin secretion during hyperglycemic clamp studies in healthy young men. Diabetes Research and Clinical Practice 2001 52 2 97 102 2-s2.0-0035055169 10.1016/S0168-8227(00)00237-0 (Pubitemid 32335602)
31. Maassen J. A., Mitochondrial diabetes: pathophysiology, clinical presentation, and genetic analysis. American Journal of Medical Genetics 2002 115 1 66 70 2-s2.0-0036079524 10.1002/ajmg.10346 (Pubitemid 34650725)
32. de Naeyer H., Ouwens D. M., van Nieuwenhove Y., Pattyn P., 'T Hart L. M., Kaufman J., Sell H., Eckel J., Cuvelier C., Taes Y. E., Ruige J. B., Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men. Obesity Facts 2011 4 5 407 416 2-s2.0-82955246255 10.1159/000333445
33. Valerio A., Cardile A., Cozzi V., Bracale R., Tedesco L., Pisconti A., Palomba L., Cantoni O., Clementi E., Moncada S., Carruba M. O., Nisoli E., TNF- α downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. The Journal of Clinical Investigation 2006 116 10 2791 2798 2-s2.0-33749442351 10.1172/JCI28570 (Pubitemid 44511642)
34. Newsholme P., Gaudel C., Krause M., Mitochondria and diabetes. An intriguing pathogenetic role. Advances in Experimental Medicine and Biology 2012 942 235 247 2-s2.0-84859907743 10.1007/978-94-007-2869-1-10
35. Bai R., Perng C., Hsu C., Wong L. C., Quantitative PCR analysis of mitochondrial DNA content in patients with mitochondrial disease. Annals of the New York Academy of Sciences 2004 1011 304 309 2-s2.0-2342530852 10.1196/annals.1293.029 (Pubitemid 38608414)
36. Andreu A. L., Martinez R., Marti R., García-Arumí E., Quantification of mitochondrial DNA copy number: pre-analytical factors. Mitochondrion 2009 9 4 242 246 2-s2.0-67349179026 10.1016/j.mito.2009.02.006