Changes in plasma levels of natural anticoagulants in disseminated intravascular coagulation: High prognostic value of antithrombin and protein C in patients with underlying sepsis or severe infection

Annals of Laboratory Medicine

Volumn 34, Issue 2, 2014, Pages 85-91

  Choi, Qute ^a   Hong, Ki Ho ^a,b   Kim, Ji Eun ^a   Kim, Hyun Kyung ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul Medical Center   (South Korea)

Author keywords

Antithrombin; Disseminated intravascular coagulation; Natural anticoagulant; Protein C; Protein S; Protein Z

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D; PLASMA PROTEIN; PLASMA PROTEIN Z; PROTEIN C; PROTEIN S;

ADULT; AGED; BLOOD; COMPLICATION; CYTOLOGY; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; HUMAN; MALE; MIDDLE AGED; MORTALITY; PROGNOSIS; PROTHROMBIN TIME; REGRESSION ANALYSIS; SEPSIS; SEVERITY OF ILLNESS INDEX; THROMBOCYTE; THROMBOCYTE COUNT;

ADULT; AGED; ANTICOAGULANTS; ANTITHROMBINS; BLOOD PLATELETS; BLOOD PROTEINS; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; PROGNOSIS; PROTEIN C; PROTEIN S; PROTHROMBIN TIME; REGRESSION ANALYSIS; SEPSIS; SEVERITY OF ILLNESS INDEX;

EID: 84897860711     PISSN: 22343806     EISSN: 22343814     Source Type: Journal    
DOI: 10.3343/alm.2014.34.2.85     Document Type: Article

References (18)

1. Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br J Haematol 2009;145:24-33.
2. Sawamura A, Gando S, Hayakawa M, Hoshino H, Kubota N, Sugano M. Effects of antithrombin III in patients with disseminated intravascular coagulation diagnosed by newly developed diagnostic criteria for critical illness. Clin Appl Thromb Hemost 2009;15:561-6.
3. Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 1992;101:816-23.
4. Macias WL and Nelson DR. Severe protein C deficiency predicts early death in severe sepsis. Crit Care Med 2004;32:S223-8.
5. Lauterbach R, Pawlik D, Radziszewska R, Wozniak J, Rytlewski K. Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns. Eur J Pediatr 2006;165:585-9.
6. Taylor FB Jr., Toh CH, Hoots WK, Wada H, Levi M, Scientific Subcommittee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001;86:1327-30.
7. Al-Shanqeeti A, van Hylckama Vlieg A, Berntorp E, Rosendaal FR, Broze GJ Jr. Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis. Thromb Haemost 2005;93:411-3.
8. Steffano B, Forastiero R, Martinuzzo M, Kordich L. Low plasma protein Z levels in patients with antiphospholipid antibodies. Blood Coagul Fibrinolysis 2001;12:411-2.
9. Kawasugi K, Wada H, Hatada T, Okamoto K, Uchiyama T, Kushimoto S, et al. Prospective evaluation of hemostatic abnormalities in overt DIC due to various underlying diseases. Thromb Res 2011;128:186-90.
10. Kaneko T and Wada H. Diagnostic criteria and laboratory tests for disseminated intravascular coagulation. J Clin Exp Hematop 2011;51:67-76.
11. Levi M and Ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999;341:586-92.
12. Maruyama I. Recombinant thrombomodulin and activated protein C in the treatment of disseminated intravascular coagulation. Thromb Haemost 1999;82:718-21.
13. Chung S, Kim JE, Kim JY, Lee DS, Han KS, Kim HK. Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation. Thromb Res 2010;125:e285-93.
14. Taylor FB, Haddad PA, Hack E, Chang AC, Peer GT, Morrissey JH, et al. Two-stage response to endotoxin infusion into normal human subjects: Correlation of blood phagocyte luminescence with clinical and laboratory markers of the inflammatory, hemostatic response. Crit Care Med 2001;29:326-34.
15. Kim SY, Kim JE, Kim HK, Kim I, Yoon SS, Park S. Higher prognostic value of soluble fibrin complexes than D-dimer and fibrin degradation product for disseminated intravascular coagulation in patients with liver cirrhosis. Blood Coagul Fibrinolysis 2013;24:150-6.
16. Corral J, Gonzalez-Conejero R, Hernandez-Espinosa D, Vicente V. Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis. Br J Haematol 2007;137:99-108.
17. Esmon CT. Protein C anticoagulant system-anti-inflammatory effects. Semin Immunopathol 2012;34:127-32.
18. Delekta PC, Apel IJ, Gu S, Siu K, Hattori Y, McAllister-Lucas LM, et al. Thrombin-dependent NF-kB activation and monocyte/endothelial adhesion are mediated by the CARMÁ3•Bcl10•MALT signalosome. J Biol Chem 2010;285:41432-42.