Predictive Genomic Testing of Children for Adult Onset Disorders: A Canadian Perspective

American Journal of Bioethics

Volumn 14, Issue 3, 2014, Pages 19-21

  Szego, Michael J ^a   Meyn, M Stephen ^a   Anderson, James A ^a   Hayeems, Robin ^a   Shuman, Cheryl ^a   Monfared, Nasim ^a   Bowdin, Sarah ^a   Shaul, Randi Zlotnik ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DECISION MAKING; ETHICS; GENETIC SCREENING; HUMAN; PARENT; PRACTICE GUIDELINE; STANDARD;

DECISION MAKING; GENETIC TESTING; HUMANS; PARENTS; PRACTICE GUIDELINES AS TOPIC;

EID: 84897744254     PISSN: 15265161     EISSN: 15360075     Source Type: Journal    
DOI: 10.1080/15265161.2013.879960     Document Type: Article

References (10)

1. Arbour, L. and Canadian Paediatric Society, with the Canadian College of Medical Geneticists. 2003. Guidelines for genetic testing of healthy children. Paediatrics and Child Health, 8 (1): 42 - 52.
2. Berg, J. S., Adams, M. Nassar, N. 2012. An informatics approach to analyzing the incidentalome. Genetics in Medicine, doi: 10.1038/gim.2012.112
3. Clayton, E. W., McCullough, L. B., Biessecker, L. G., Joffe, S., Ross, L. F. and Wolf, S. M. 2014. Addressing the ethical challenges in genetic testing and sequencing of children. American Journal of Bioethics, 14 (3) 3-9
4. Geelen, E., Van Hoyweghen, I., Doevendans, P. A., Marcelis, C. L. and Horstman, K. 2011. Constructing "best interests": Genetic testing of children in families with hypertrophic cardiomyopathy. American Journal of Medical Genetics A, 155A (8): 1930 - 1938. doi: 10.1002/ajmg.a.34107
5. Green, R. C., Berg, J. S. Grody, W. W. 2013. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genetics in Medicine, 15 (7): 565 - 574. doi: 10.1038/gim.2013.73
6. Johnston, J. J., Rubinstein, W. S. Facio, F. M. 2012. Secondary variants in individuals undergoing exome sequencing: Screening of 572 individuals identifies high-penetrance mutations in cancer-susceptibility genes. American Journal of Human Genetics, 91 (1): 97 - 108. doi: 10.1016/j.ajhg.2012.05.021
7. Ross, L. F., Saal, H. M., David, K. L., Anderson, R. R. and American Academy of Pediatrics, and American College of Medical Genetics and Genomics. 2013. Technical report: Ethical and policy issues in genetic testing and screening of children. Genetics in Medicine, 15 (3): 234 - 245. doi: 10.1038/gim.2012.176
8. Wade, C. H., Tarini, B. A. and Wilfond, B. S. 2013. Growing up in the genomic era: Implications of whole-genome sequencing for children, families, and pediatric practice. Annual Review of Genomics and Human Genetics, 14: 535 - 555. doi: 10.1146/annurev-genom-091212-153425
9. Wilfond, B. and Ross, L. F. 2009. From genetics to genomics: Ethics, policy, and parental decision-making. Journal of Pediatric Psychology, 34 (6): 639 - 647. doi: 10.1093/jpepsy/ jsn075
10. Zawati, M. H., Parry, D. Thorogood, A. 2013. Reporting results from whole-genome and whole-exome sequencing in clinical practice: A proposal for Canada?. Journal of Medical Genetics, doi: 10.1136/jmedgenet-2013-101934