Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Park, Ji Won ^a   Kim, Seung C ^b   Kim, Won K ^a   Hong, Jun P ^a   Kim, Kyung Hee ^a   Yeo, Hyun Y ^a   Lee, Jae Y ^a   Kim, M S ^a   Kim, Jong H ^a   Yang, Se Y ^a   Kim, Dae Y ^a   Oh, Jae H ^a   Cho, Jae Y ^c   Yoo, Byong C ^a  

^a National Cancer Center   (South Korea)

^b Mokdong Hospital   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

5 FU resistance; Chemoradiotherapy; Colon cancer; mPEPCK; Prediction

Indexed keywords

FLUOROURACIL; INITIATION FACTOR 4E BINDING PROTEIN 1; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE B; PHOSPHOENOLPYRUVATE; PHOSPHOENOLPYRUVATE CARBOXYLASE KINASE; PROTEIN SERINE THREONINE KINASE;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CHEMORADIOTHERAPY; CHEMOSENSITIVITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; VERY ELDERLY; WESTERN BLOTTING; CANCER GRADING; CANCER STAGING; COLONIC NEOPLASMS; DOWN REGULATION; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; MITOCHONDRION; PATHOLOGY; RADIATION DOSE; RADIATION RESPONSE; TUMOR CELL LINE;

ADULT; AGED; AGED, 80 AND OVER; CELL LINE, TUMOR; CHEMORADIOTHERAPY; COLONIC NEOPLASMS; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MITOCHONDRIA; NEOPLASM GRADING; NEOPLASM STAGING; PHOSPHOENOLPYRUVATE; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; SIGNAL TRANSDUCTION;

EID: 84897572150     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-160     Document Type: Article

References (24)

1. Yamamoto T, Varani J, Soong HK, Lichter PR. Effects of 5-fluorouracil and mitomycin C on cultured rabbit subconjunctival fibroblasts. Ophthalmology 1990, 97(9):1204-1210. 10.1016/S0161-6420(90)32456-9, 2122349.
2. Mallick KS, Hajek AS, Parrish RK. Fluorouracil (5-FU) and cytarabine (ara-C) inhibition of corneal epithelial cell and conjunctival fibroblast proliferation. Arch Ophthalmol 1985, 103(9):1398-1402. 10.1001/archopht.1985.01050090150052, 4038134.
3. Minsky BD, Cohen AM, Enker WE, Saltz L, Guillem JG, Paty PB, Kelsen DP, Kemeny N, Ilson D, Bass J, Conti J. Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer. Int J Radiat Oncol Biol Phys 1997, 37(2):289-295. 10.1016/S0360-3016(96)00487-7, 9069299.
4. Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 2008, 14(7):2128-2136. 10.1158/1078-0432.CCR-07-4722, 18381954.
5. Aschele C, Sobrero A, Faderan MA, Bertino JR. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 1992, 52(7):1855-1864.
6. Agca C, Greenfield RB, Hartwell JR, Donkin SS. Cloning and characterization of bovine cytosolic and mitochondrial PEPCK during transition to lactation. Physiol Genomics 2002, 11(2):53-63.
7. Carlson GM, Holyoak T. Structural insights into the mechanism of phosphoenolpyruvate carboxykinase catalysis. J Biol Chem 2009, 284(40):27037-27041. 10.1074/jbc.R109.040568, 2785633, 19638345.
8. Méndez-Lucas A, Duarte JA, Sunny NE, Satapati S, He T, Fu X, Bermúdez J, Burgess SC, Perales JC. PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis. J Hepatol 2013, 59(1):105-113. 10.1016/j.jhep.2013.02.020, 3910155, 23466304.
9. Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab 2007, 5(4):313-320. 10.1016/j.cmet.2007.03.004, 2680089, 17403375.
10. Yoo BC, Jeon E, Hong SH, Shin YK, Chang HJ, Park JG. Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line. Clin Cancer Res 2004, 10(12 Pt 1):4176-4184.
11. Kim DY, Jung KH, Kim TH, Kim DW, Chang HJ, Jeong JY, Kim YH, Son SH, Yun T, Hong CW, Sohn DK, Lim SB, Choi HS, Jeong SY, Park JG. Comparison of 5-fluorouracil/leucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2007, 67(2):378-384. 10.1016/j.ijrobp.2006.08.063, 17097835.
12. Yeo SG, Oh JH, Kim DY, Baek JY, Kim SY, Park JW, Kim MJ, Chang HJ, Kim TH, Lee JH, Jang HS, Kim JG, Lee MA, Nam TK. Preoperative short-course concurrent chemoradiation therapy followed by delayed surgery for locally advanced rectal cancer: a phase 2 multicenter study (KROG 10-01). Int J Radiat Oncol Biol Phys 2013, 86(1):34-39. 10.1016/j.ijrobp.2012.11.018, 23265569.
13. Greene FL, American Joint Committee on Cancer, American Cancer Society AJCC Cancer Staging Handbook: from the AJCC Cancer Staging Manual 2002, New York: Springer, 6, American Joint Committee on Cancer, American Cancer Society.
14. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 1997, 12(1):19-23. 10.1007/s003840050072, 9112145.
15. Davies GF, Khandelwal RL, Wu L, Juurlink BH, Roesler WJ. Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism. Biochem Pharmacol 2001, 62(8):1071-1079. 10.1016/S0006-2952(01)00764-X, 11597575.
16. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Regulation of cellular metabolism by protein lysine acetylation. Science 2010, 327(5968):1000-1004. 10.1126/science.1179689, 3232675, 20167786.
17. Shin YK, Yoo BC, Chang HJ, Jeon E, Hong SH, Jung MS, Lim SJ, Park JG. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. Cancer Res 2005, 65(8):3162-3170.
18. Yoo BC, Ku JL, Hong SH, Shin YK, Park SY, Kim HK, Park JG. Decreased pyruvate kinase M2 activity linked to cisplatin resistance in human gastric carcinoma cell lines. Int J Cancer 2004, 108(4):532-539. 10.1002/ijc.11604, 14696117.
19. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988, 335(6189):440-442. 10.1038/335440a0, 3262202.
20. Helmreich EJM. The Biochemistry of Cell Signalling 2001, 238-243. Oxford; New York: Oxford University Press.
21. Hsu SY, Kaipia A, Zhu L, Hsueh AJ. Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. Mol Endocrinol 1997, 11(12):1858-1867.
22. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999, 399(6735):483-487. 10.1038/20959, 10365962.
23. Rojo F, Najera L, Lirola J, Jimenez J, Guzman M, Sabadell MD, Baselga J, Ramon y Cajal S. 4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis. Clin Cancer Res 2007, 13(1):81-89. 10.1158/1078-0432.CCR-06-1560, 17200342.
24. Armengol G, Rojo F, Castellvi J, Iglesias C, Cuatrecasas M, Pons B, Baselga J, Ramon Cajal S. 4E-binding protein 1: a key molecular " funnel factor" in human cancer with clinical implications. Cancer Res 2007, 67(16):7551-7555. 10.1158/0008-5472.CAN-07-0881, 17699757.