Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: A randomized clinical trial

Early Human Development

Volumn 90, Issue SUPPL.1, 2014, Pages

  Manzoni, Paolo ^a   Meyer, Michael ^b   Stolfi, Ilaria ^c   Rinaldi, Matteo ^d   Cattani, Silvia ^e   Pugni, Lorenza ^f   Romeo, Mario Giovanni ^g   Messner, Hubert ^h   Decembrino, Lidia ⁱ   Laforgia, Nicola ^j   Vagnarelli, Federica ^k   Memo, Luigi ^l   Bordignon, Linda ^l   Maule, Milena ^m   Gallo, Elena ^a   Mostert, Michael ^m   Quercia, Michele ^j   Bollani, Lina ⁱ   Pedicino, Roberto ^c   Renzullo, Livia ^h   Betta, Pasqua ^g   Ferrari, Fabrizio ^e   Alexander, Tanith ^b   Magaldi, Rosario ^d   Farina, Daniele ^a   Mosca, Fabio ^f   Stronati, Mauro ^k   more..

^a S ANNA HOSPITAL   (Italy)

^b MIDDLEMORE HOSPITAL   (New Zealand)

^c POLICLINICO UMBERTO I   (Italy)

^d OSPEDALI RIUNITI   (Italy)

^e UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^f UNIVERSITY OF MILAN   (Italy)

^g Azienda Ospedaliera Universitaria VE Ferrarotto   (Italy)

^h Ospedale Regionale   (Italy)

ⁱ FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^j POLICLINICO   (Italy)

^k NICU   (Italy)

^l CA FONCELLO HOSPITAL   (Italy)

^m UNIVERSITY OF TURIN   (Italy)

more..

Author keywords

Lactoferrin; Necrotising enterocolitis; Neonate; Preterm; Probiotics; Sepsis

Indexed keywords

BOVINE LACTOFERRIN; LACTOBACILLUS RHAMNOSUS GG; LACTOFERRIN; PLACEBO; PROBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ABSENCE OF SIDE EFFECTS; ARTICLE; ARTIFICIAL MILK; BIRTH; BREAST MILK; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG HYPERSENSITIVITY; FEMALE; HOSPITAL DISCHARGE; HUMAN; INFANT FEEDING; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NECROTIZING ENTEROCOLITIS; NEW ZEALAND; NEWBORN; NEWBORN DISEASE; NEWBORN INTENSIVE CARE; RANDOMIZED CONTROLLED TRIAL; TERTIARY CARE CENTER; VERY LOW BIRTH WEIGHT; ANIMAL; BOVINAE; CLINICAL TRIAL; ENTEROCOLITIS, NECROTIZING;

ANIMALS; ANTI-INFECTIVE AGENTS; CATTLE; ENTEROCOLITIS, NECROTIZING; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; LACTOFERRIN; MALE;

EID: 84897561629     PISSN: 03783782     EISSN: 18726232     Source Type: Journal    
DOI: 10.1016/S0378-3782(14)70020-9     Document Type: Article

References (13)

1. Sherman MP, Bennett SH, Hwang FF, Yu C Neonatal small bowel epithelia: enhancing anti-bacterial defense with lactoferrin and Lactobacillus GG. Biometals 2004, 17(3):285-289.
2. Adamkin DH Mother's Milk, Feeding Strategies, and Lactoferrin to Prevent Necrotizing Enterocolitis. J Parenter and Enteral Nutr 2012, 36(Suppl 1):25S-259.
3. Deshpande G, Rao S, Patole S, Bulsara M Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010, 125(5):921-930.
4. Lönnerdal B, Jiang R, Du X Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities. J Pediatr Gastroenterol Nutr 2011, 53(6):606-614.
5. Buccigrossi V, de Marco G, Bruzzese E, Ombrato L, Bracale I, Polito G, et al. Lactoferrin induces concentration-dependent functional modulation of intestinal proliferation and differentiation. Pediatr Res 2007, 61(4):410-414.
6. Manzoni P, Rinaldi M, Cattani S, Pugni L, Romeo MG, Messner H, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low birth weight neonates: a randomized trial. JAMA 2009, 302(13):1421-1428.
7. Manzoni P, Mostert M, Stronati M Lactoferrin for prevention of neonatal infections. Curr Opin Infect Dis 2011, 24:177-182.
8. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate 2002, 82:103-108.
9. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis: therapeutic decisions based upon clinical staging. Ann Surg 1978, 187(1):1-7.
10. Zuccotti GV, Vigano A, Borelli M, Saresella M, Giacomet V, Clerici M Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapynaïve children. Int J Antimicrob Agents 2007, 29(3):353-355.
11. Sherman M New concepts of microbial translocation in the neonatal intestine: mechanisms and prevention. Clin Perinatol 2010, 37:565-579.
12. Berlutti F, Schippa S, Morea C, Sarli S, Perfetto B, Donnarumma G, et al. Lactoferrin downregulates pro-inflammatory cytokines upexpressed in intestinal epithelial cells infected with invasive or noninvasive Escherichia coli strains. Biochem Cell Biol 2006, 84(3):351-357.
13. Raghuveer TS, McGuire EM, Martin SM, Wagner BA, Rebouché CJ, Buettner GR, et al. Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products. Pediatr Res 2002, 52(6):964-972.