Pharmacological inhibition of cochlear mitochondrial respiratory chain induces secondary inflammation in the lateral wall: A potential therapeutic target for sensorineural hearing loss

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Fujioka, Masato ^a   Okamoto, Yasuhide ^b,e   Shinden, Seiichi ^c,e   Okano, Hirotaka James ^a,d   Okano, Hideyuki ^a   Ogawa, Kaoru ^a   Matsunaga, Tatsuo ^e  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Inagi Municipal Hospital   (Japan)

^c Imperial Foundation Saiseikai Utsunomiya Hospital   (Japan)

^d JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NATIONAL HOSPITAL ORGANIZATION TOKYO MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCL1 CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; 3-NITROPROPIONIC ACID; AUTACOID; CHEMOKINE; NITRO DERIVATIVE; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CCL1 GENE; CCL2 GENE; CCL3 GENE; CCL4 GENE; CCL5 GENE; CCR2 GENE; CCR5 GENE; COCHLEA; CONTROLLED STUDY; CX3CL1 GENE; CX3CR1 GENE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA MICROARRAY; DRUG TARGETING; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MITOCHONDRIAL RESPIRATION; MOLECULAR PATHOLOGY; NONHUMAN; PERCEPTION DEAFNESS; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RESPIRATORY CHAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; DRUG EFFECTS; ELECTRON TRANSPORT; GENE EXPRESSION PROFILING; GENETICS; GENOME; HEARING LOSS, SENSORINEURAL; INFLAMMATION; INJURIES; MACROPHAGE; METABOLISM; MITOCHONDRION; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME; UPREGULATION;

ANIMALS; CHEMOKINES; COCHLEA; ELECTRON TRANSPORT; FEMALE; GENE EXPRESSION PROFILING; GENOME; HEARING LOSS, SENSORINEURAL; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MACROPHAGES; MITOCHONDRIA; NITRO COMPOUNDS; PROPIONATES; RATS, SPRAGUE-DAWLEY; TIME FACTORS; UP-REGULATION;

EID: 84897552243     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090089     Document Type: Article

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