Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking pi3k-akt pathway

The Scientific World Journal

Volumn 2014, Issue , 2014, Pages

  Huang, Qiang ^a   Liu, Zhen ^b,c   Xie, Fang ^b,c   Liu, Chenhai ^b,c   Shao, Feng ^b,c   Zhu, Cheng Lin ^b,c   Hu, Sanyuan ^a  

^a SHANDONG UNIVERSITY   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c Anhui Province Key Laboratory of Molecular Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; FRAGILE HISTIDINE TRIAD PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; SURVIVIN; ACID ANHYDRIDE HYDROLASE; TUMOR PROTEIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER PROGNOSIS; CARCINOMA CELL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL PROLIFERATION; CHOLANGIOCARCINOMA; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ACID ANHYDRIDE HYDROLASES; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLANGIOCARCINOMA; HUMANS; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84897487587     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2014/179698     Document Type: Article

References (18)

1. Friman S., Cholangiocarcinoma-current treatment options. Scandinavian Journal of Surgery 2011 100 1 30 34 2-s2.0-79952976370
2. Mishra D. K., Chen Z., Wu Y., Sarkissyan M., Koeffler H. P., Vadgama J. V., Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. Molecular Cancer Therapeutics 2010 9 1 33 45 2-s2.0-73949121977 10.1158/1535-7163.MCT-09-0486
3. Vaiphei K., Rangan A., Singh R., Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma. World Journal of Gastrointestinal Oncology 2012 4 12 250 258 10.4251/wjgo.v4.i12.250
4. Yin D. T., Wang L., Sun J., Yin F., Yan Q., Shen R., He G., Gao J. X., Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma. International Journal of Clinical and Experimental Pathology 2010 3 5 482 491 2-s2.0-77956033429
5. Yin D. T., Wang L., Sun J., Yin F., Yan Q., Shen R., Gao J. X., He G., Homozygous deletion but not mutation of exons 5 and 8 of the Fragile Histidine Triad (FHIT) gene is associated with features of differentiated thyroid carcinoma. Annals of Clinical & Laboratory Science 2010 40 3 267 272 2-s2.0-77955826140
6. Huang Q., Xie F., Tang Z., Liu C., Wang C., Hu Y., Qiu L., Wang S., You H., Zhu K., Xu P., FHIT promotes the apoptosis of QBC939 by reducing the expression of cyclin D1. Hepato-Gastroenterology 2011 58 107-108 713 718 2-s2.0-80051646299
7. Lin C. C., Zhou J. P., Liu Y. P., Liu J. J., Yang X. N., Jazag A., Zhang Z. P., Guleng B., Ren J. L., The silencing of Pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by inhibiting the PI3K/Akt pathway. PLoS ONE 2012 7 12 e51916 10.1371/journal.pone. 0051916
8. Schmitz K. J., Lang H., Wohlschlaeger J., Sotiropoulos G. C., Reis H., Schmid K. W., Baba H. A., AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma. World Journal of Gastroenterology 2007 13 48 6470 6477 2-s2.0-38349035898 10.3748/wjg.13.6470
9. Ohta M., Inoue H., Cotticelli M. G., Kastury K., Baffa R., Palazzo J., Siprashvili Z., Mori M., McCue P., Druck T., Croce C. M., Huebner K., The human FHIT gene, spanning the chromosome 3p14.2 fragile site and renal cell carcinoma associated translocation breakpoint, is abnormal in digestive tract cancer. Cell 1996 84 4 587 597 (Pubitemid 26071739)
10. Romero I., Martinez M., Garrido C., Collado A., Algarra I., Garrido F., Garcia-Lora A. M., The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells. The Journal of Pathology 2012 227 3 367 379 10.1002/path.4029
11. Wang O., Wang C. Y., Shi J., Nie M., Xia W. B., Li M., Jiang Y., Guan H., Meng X. W., Xing X. P., Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors. Chinese Medical Journal 2012 125 16 2895 2901
12. Gopalakrishnan V. K., Banerjee A. G., Vishwanatha J. K., Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer cells. Pancreatology 2003 3 4 293 302 2-s2.0-0042674157 10.1159/000071767 (Pubitemid 36928753)
13. Ottey M., Han S. Y., Druck T., Barnoski B. L., McCorkell K. A., Croce C. M., Raventos-Suarez C., Fairchild C. R., Wang Y., Huebner K., Fhit -deficient normal and cancer cells are mitomycin C and UVC resistant. British Journal of Cancer 2004 91 9 1669 1677 2-s2.0-8444235237 10.1038/sj.bjc.6602058 (Pubitemid 39546140)
14. Shi M., Zhang H., Li M., Xue J., Fu Y., Yan L., Zhao X., Normal endometrial stromal cells regulate survival and apoptosis signaling through PI3K/AKt/Survivin pathway in endometrial adenocarcinoma cells in vitro. Gynecologic Oncology 2011 123 2 387 392 2-s2.0-80054735834 10.1016/j.ygyno.2011. 07.004
15. Ye Q., Cai W., Zheng Y., Evers B. M., She Q. B., ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. Oncogene 2013 10.1038/onc.2013.122
16. Mita A. C., Mita M. M., Nawrocki S. T., Giles F. J., Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clinical Cancer Research 2008 14 16 5000 5005 2-s2.0-52649172153 10.1158/1078-0432.CCR-08-0746
17. Tang C., Lu Y. H., Xie J. H., Wang F., Zou J. N., Yang J. S., Xing Y. Y., Xi T., Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anti-Cancer Drugs 2009 20 4 249 258 2-s2.0-63449089496 10.1097/CAD.0b013e328327d476
18. Semba S., Trapasso F., Fabbri M., McCorkell K. A., Volinia S., Druck T., Iliopoulos D., Pekarsky Y., Ishii H., Garrison P. N., Barnes L. D., Croce C. M., Huebner K., Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit -tyrosine 114 (Y114) is essential. Oncogene 2006 25 20 2860 2872 2-s2.0-33646681899 10.1038/sj.onc.1209323 (Pubitemid 43739236)