Eltrombopag: A stem cell cookie?

Blood

Volumn 123, Issue 12, 2014, Pages 1774-1775

  Marsh, Judith C W ^a   Mufti, Ghulam J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ELTROMBOPAG; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; STEM CELL FACTOR; THROMBOPOIETIN; THYMOCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; BONE MARROW; DISEASE SEVERITY; DYSERYTHROPOIESIS; FOLLOW UP; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALIGNANT TRANSFORMATION; MYELODYSPLASTIC SYNDROME; NOTE; PRIORITY JOURNAL; TREATMENT RESPONSE;

ANEMIA, APLASTIC; BENZOATES; FEMALE; HEMATOPOIESIS; HUMANS; HYDRAZINES; MALE; PYRAZOLES;

EID: 84897484340     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-02-553404     Document Type: Note

References (10)

1. Desmond R, Townsley DM, Dumitriu B, et al. Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood. 2014;123(12):1818-1825.
2. Olnes MJ, Scheinberg P, Calvo KR, et al. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med. 2012;367(1):11-19.
3. Young NS. Current concepts in the pathophysiology and treatment of aplastic anemia. Hematology (Am Soc Hematol Educ Program). 2013;2013:76-81.
4. Kordasti S, Marsh J, Al-Khan S, et al. Functional characterization of CD4+ T cells in aplastic anemia. Blood. 2012;119(9):2033-2043.
5. Marsh JCW, Ganser A, Stadler M. Hematopoietic growth factors in the treatment of acquired bone marrow failure states. Semin. Haematol. 2007 44(3):138-147.
6. Solar GP, Kerr WG, Zeigler FC, et al. Role of c-mpl in early hematopoiesis. Blood. 1998;92(1):4-10. (Pubitemid 28303168)
7. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood. 1996;87(6):2162-2170.
8. Bao W, Bussel JB, Heck S, et al. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood. 2010;116(22):4639-4645.
9. Jiang J, Kulasekararaj AG, Smith AE, et al. Somatic mutations implicated in myeloid malignancies are frequent in idiopathic aplastic anemia and its relevance to disease classi fication and treatment- a comprehensive analysis of 150 patients. Blood. 2013;122(21):803.
10. Sloand EM, Yong ASM, Ramkissoon S, et al. Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor. Proc Natl Acad Sci USA. 2006;103(39):14483-14488. (Pubitemid 44484776)