The novel antihyperglycaemic action of Hunteria umbellata seed fractions mediated via intestinal glucose uptake inhibition

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 9, Issue 1, 2012, Pages

  Adeneye, A A ^a,b   Adeyemi, O O ^b   Agbaje, E O ^b   Sofidiya, M O ^b  

^a LAGOS STATE UNIVERSITY   (Nigeria)

^b UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

Alkaloid fraction; Hunteria umbellata aqueous seed extract; Intestinal glucose uptake inhibition; Normal and alloxan induced hyperglycaemic rats

Indexed keywords

ACETIC ACID ETHYL ESTER; ALKALOID; ALLOXAN; ANTIDIABETIC AGENT; BUTANOL; CHLOROFORM; GLUCOSE; HUNTERIA UMBELLATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; APOCYNACEAE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; GASTROINTESTINAL ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUNTERIA UMBELLATA; HYPERGLYCEMIA; MALE; METABOLIC REGULATION; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PHYTOCHEMISTRY; PLANT SEED; RAT; REPEATED DRUG DOSE; SOLVENT EFFECT; THIN LAYER CHROMATOGRAPHY; TREATMENT DURATION; ANIMAL; BLOOD; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; INTESTINE; METABOLISM; PHYTOTHERAPY; WISTAR RAT;

ANIMALS; APOCYNACEAE; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INTESTINES; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; SEEDS;

EID: 84897364985     PISSN: None     EISSN: 01896016     Source Type: Journal    
DOI: 10.4314/ajtcam.v9i1.3     Document Type: Article

References (21)

1. Adeneye, A.A. and Adeyemi, O.O. (2009a). Hypoglycaemic effects of the aqueous seed extract of Hunteria umbellata in normoglycaemic and glucose and nicotine-induced hyperglycaemic rats. International Journal of Natural Products Research 2(1): 9-18.
2. Adeneye, A.A. and Adeyemi, O.O. (2009b). Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes. Journal of Ethnopharmacology 126(2): 238-243.
3. Adeneye, A.A., Adeyemi, O.O. and Agbaje, E.O. (2010). Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia. Journal of Ethnopharmacology 130(2): 307-314.
4. Adegoke, E.A. and Alo, B. (1986). Abere-amines: Water soluble seed alkaloids from Hunteria umbellata. Phytochemistry 25(6): 1461-1468.
5. Adeoye, B.A. and Oyedapo, O.O. (2004). Toxicity of Erythrophleum guineense stem-bark: role of alkaloidal fraction. African Journal of Traditional, Complementary and Alternative Medicine 1: 45-54.
6. Boone, M.J. (2006). Hunteria umbellata (K. Schum.) Hallier f. In: Schmelzer, G.H. and Gurib-Fakim, A., editors. Prota 11: Medicinal plants/Plantes médicinales (CD-ROM). PROTA, Wageningen, Netherlands.
7. Bouquet, A. and Debray, M. (1974). Plantes médicinales de la Côte d'Ivoire. Travaux et Documents No 32, pp. 231. ORSTOM, Paris, France.
8. Falodun, A., Nworgu, Z.A.M. and Ikponmwonsa, M.O. (2006). Phytochemical components of Hunteria umbellata (K. Schum) and its effect on isolated non-pregnant rat uterus in oestrus. Pakistani Journal of Pharmaceutical Sciences 19(3): 256-258.
9. Fattorusso, E. and Taglialatela-Scafati, O. (2007). Glycosidase-inhibiting alkaloids: isolation, structure and application. In: Modern alkaloids: structure, isolation, synthesis and biology. Wiley-VCH Verlag GmbH and Company, Weinheim, Germany, pp. 111-133.
10. Fuji, M., Takei, I. and Umezawa, K. (2009). Antidiabetic effect of orally administered conophylline-containing plant extract on streptozotocin-treated and Goto-Kakizaki rats. Biomedical Pharmacotherapy 63(10): 710-716.
11. Hutchinson, J. and Dalziel, J.M., 1963. Hunteria. In: Flora of West Tropical Africa. Vol. 2, 2nd edition. Royal Botanic Gardens, Kew, pp. 62-63.
12. Igbe, I., Omogbai, E.K.I. and Ozolua, R.I. (2009). Hypoglycaemic activity of aqueous seed extract of Hunteria umbellata in normal and streptozotocin-induced diabetic rats. Pharmaceutical Biology 47(10): 1011-1016.
13. Okonta, J.M. and Aguwa, C.N. (2007). Evaluation of hypoglycaemic activities of glycosides and alkaloids extracts of Picralima nitida Stapf. (Apocynaceae) seed. International Journal of Pharmacology 3(6): 505-509.
14. Prince, P.S.M. and Menon, V.P. (2001). Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytotherapy Research 15(3): 213-218.
15. Srivastava, Y., Venkatakrishna-Bhatt, H. and Verma, Y. (1988). Effect of Momordica charantia Linn. pomous aqueous extract on cataractogenesis in murine alloxan diabetics. Pharmacology Research Communications 20: 201-209.
16. Svoboda, G.H., Gorman, M. and Root, M.A. (1964). Alkaloids of Vinca rosea (Catharanthus roseus): A preliminary report on hypoglycaemic activity. Llyodia 27: 361-363.
17. United States National Institutes for Health publication (1985),. no. 85-23.
18. Vats, V., Yadav, S.P., Biswas, N.R. and Grover, J.K. (2004). Anti-cataract activity of Pterocarpus marsupium bark and Trigonella foenum-graecum seeds extract in alloxan diabetic rats. Journal of Ethnopharmacology 93: 289-294.
19. Yang, J.H., Li, Z.Y., Li, L., Wang, Y.X., (1999). Diterpenoids Alkaloids from Aconitum episcopale. Phytochemistry 50: 345-346.
20. Yoshikawa, M., Morikawa, T., Matsuda, H., Tanabe, G. and Muraoka, O. (2002). Absolute stereostructure of potent α-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulphate inner salt structure from Salacia reticulata. Bio-organic and Medicinal Chemistry 10(5): 1547-1554.
21. Yoshikawa, M., Nakamura, S., Ozaki, K., Kumahara, A., Morikawa, T. and Matsuda, H. (2007). Structures of steroidal alkaloidals oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant, Solanum lycocarpum. Journal of Natural Products 70: 210-214.