Respiratory recovery following organophosphate poisoning in a rat model is suppressed by isolated hypoxia at the point of apnea

Toxicology

Volumn 302, Issue 2-3, 2012, Pages 242-247

  Gaspari, Romolo J ^a   Paydarfar, David ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Apnea; Gasping; Organophosphate; Respiratory control

Indexed keywords

DICHLORVOS; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; ARTIFICIAL VENTILATION; BREATHING; BREATHING RATE; CONTROLLED STUDY; HYPOXIA; MALE; NONHUMAN; ORGANOPHOSPHATE POISONING; PHRENIC NERVE; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; TISSUE OXYGENATION; ACUTE DISEASE; ANIMAL; ANOXIA; BREATHING MECHANICS; DRUG EFFECT; METABOLISM; PATHOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALIA; RATTUS;

ACUTE DISEASE; ANIMALS; ANOXIA; APNEA; DICHLORVOS; MALE; ORGANOPHOSPHATE POISONING; OXYGEN; RATS; RATS, WISTAR; RESPIRATORY MECHANICS;

EID: 84897119504     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.08.005     Document Type: Article

References (12)

1. Arieli, R., 1994. Normoxic, hyperoxic, and hypoxic ventilation in rats continuously exposed for 60 h to 1 ATA O2. Aviation Space Environ. Med. 65, 1122-1127.
2. Arieli, R., Kerem, D., Melamed, Y., 1988. Hyperoxic exposure affects the ventilatory response to hypoxia in awake rats. J. Appl. Physiol. 64, 181-186.
3. Armitage, P., Berry, G., 2001. Statistical Methods in Medical Research. Blackwell Scientific, Boston, MA.
4. Coles, S.K., Dick, T.E., 1996. Neurones in the ventrolateral pons are required for posthypoxic frequency decline in rats. J. Physiol. 497 (Pt 1), 79-94.
5. Dean, J.B., Mulkey, D.K., Henderson 3rd, R.A., Potter, S.J., Putnam, R.W., 2004. Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons. J. Appl. Physiol. 96, 784-791.
6. Fung, M.L., Wang, W., St. John, W.M., 1994. Medullary loci critical for expression of gasping in adult rats. J. Physiol. 480 (Pt. 3), 597-611.
7. Gaspari, R.J., Paydarfar, D., 2007. Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model. Neurotoxicology 28, 664-671.
8. Guntheroth, W.G., Kawabori, I., 1975. Hypoxic apnea and gasping. J. Clin. Invest. 56, 1371-1377.
9. Nava, S., Bellemare, F., 1989. Cardiovascular failure and apnea in shock. J. Appl. Physiol. 66, 184-189.
10. St. John, W.M., Zhou, D., Fregosi, R.F., 1989. Expiratory neural activities in gasping. J. Appl. Physiol. 66, 223-231.
11. St. John, W.M., 1998. Neurogenesis of patterns of automatic ventilatory activity. Prog. Neurobiol. 56, 97-117.
12. Watt, J.G., P.R., D., J.H., C., 1942. Effects of inhalation of 100 per cent oxygen upon respiration of anesthetized dogs before and after chemoreceptor denervation. Am. J. Physiol. 138, 610-617.