Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection

American Journal of Transplantation

Volumn 14, Issue 4, 2014, Pages 831-840

  Greenland, J R ^a,b   Jewell, N P ^c   Gottschall, M ^a   Trivedi, N N ^a,b   Kukreja, J ^a   Hays, S R ^a   Singer, J P ^a   Golden, J A ^a   Caughey, G H ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

lung; lymphocyte; NK cell; rejection

Indexed keywords

ACUTE GRAFT REJECTION; ADULT; ARTICLE; BRONCHIOLITIS OBLITERANS; CD25+ T LYMPHOCYTE; CELL COUNT; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CYSTIC FIBROSIS; EOSINOPHIL; FEMALE; GRAFT RECIPIENT; HUMAN; IMMUNOPHENOTYPING; LUNG ALVEOLUS CELL; LUNG FIBROSIS; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MONOCYTE; NATURAL KILLER CELL; PREDICTIVE VALUE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RETROSPECTIVE STUDY; SCORING SYSTEM; TRANSBRONCHIAL BIOPSY; ALLOGRAFT; CYTOLOGY; CYTOTOXICITY; FOLLOW UP; GRAFT REJECTION; IMMUNOLOGY; LUNG DISEASES; MICROBIOLOGY; MORTALITY; POSTOPERATIVE COMPLICATIONS; PROCEDURES; PROGNOSIS; RISK FACTOR; SURVIVAL RATE;

ALLOGRAFTS; BRONCHIOLITIS OBLITERANS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LUNG DISEASES; LUNG TRANSPLANTATION; LYMPHOCYTES; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE;

EID: 84897115343     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12630     Document Type: Article

References (36)

1. Christie JD, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth adult lung and heart-lung transplant report-2011. J Heart Lung Transplant 2011; 30: 1104-1122.
2. Hopkins PM, Aboyoun CL, Chhajed PN, et al. Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis. Am J Respir Crit Care Med 2004; 170: 1022-1026.
3. Hachem RR, Khalifah AP, Chakinala MM, et al. The significance of a single episode of minimal acute rejection after lung transplantation. Transplantation 2005; 80: 1406-1413.
4. Greenland JR, Jones KD, Hays SR, et al. Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2013; 187: 417-423.
5. De Vito Dabbs A, Hoffman LA, Iacono AT, Zullo TG, McCurry KR, Dauber JH., Are symptom reports useful for differentiating between acute rejection and pulmonary infection after lung transplantation ? Heart Lung 2004; 33: 372-380.
6. Kukafka DS, O'Brien GM, Furukawa S, Criner GJ., Surveillance bronchoscopy in lung transplant recipients. Chest 1997; 111: 377-381.
7. Glanville AR., Bronchoscopic monitoring after lung transplantation. Semin Respir Crit Care Med 2010; 31: 208-221.
8. Diette GB, Wiener CM, White P Jr., The higher risk of bleeding in lung transplant recipients from bronchoscopy is independent of traditional bleeding risks: Results of a prospective cohort study. Chest 1999; 115: 397-402.
9. Arcasoy SM, Berry G, Marboe CC, et al. Pathologic interpretation of transbronchial biopsy for acute rejection of lung allograft is highly variable. Am J Transplant 2011; 11: 320-328.
10. Chakinala MM, Ritter J, Gage BF, et al. Reliability for grading acute rejection and airway inflammation after lung transplantation. J Heart Lung Transplant 2005; 24: 652-657.
11. Stephenson A, Flint J, English J, et al. Interpretation of transbronchial lung biopsies from lung transplant recipients: Inter-, intraobserver agreement. Can Respir J 2005; 12: 75-77.
12. Bhorade SM, Husain AN, Liao C, et al. Interobserver variability in grading transbronchial lung biopsy specimens after lung transplantation. Chest 2013; 143: 1717-1724.
13. Khalifah AP, Hachem RR, Chakinala MM, et al. Minimal acute rejection after lung transplantation: A risk for bronchiolitis obliterans syndrome. Am J Transplant 2005; 5: 2022-2030.
14. Vos R, Vanaudenaerde BM, Verleden SE, et al. Bronchoalveolar lavage neutrophilia in acute lung allograft rejection and lymphocytic bronchiolitis. J Heart Lung Transplant 2010; 29: 1259-1269.
15. Patil J, Lande JD, Li N, Berryman TR, King RA, Hertz MI., Bronchoalveolar lavage cell gene expression in acute lung rejection: Development of a diagnostic classifier. Transplantation 2008; 85: 224-231.
16. Vanaudenaerde BM, Dupont LJ, Wuyts WA, et al. The role of interleukin-17 during acute rejection after lung transplantation. Eur Respir J 2006; 27: 779-787.
17. Bewig B, Stewart S, Bottcher H, et al. Eosinophilic alveolitis in BAL after lung transplantation. Transpl Int 1999; 12: 266-272.
18. Tikkanen J, Lemstrom K, Halme M, Pakkala S, Taskinen E, Koskinen P., Cytological monitoring of peripheral blood, bronchoalveolar lavage fluid, and transbronchial biopsy specimens during acute rejection and cytomegalovirus infection in lung and heart-lung allograft recipients. Clin Transplant 2001; 15: 77-88.
19. + T-cell maturation following lung transplantation: The differential impact of CMV and acute rejection. Transpl Immunol 2007; 18: 186-192.
20. + cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. Transplantation 2010; 90: 540-546.
21. Tiroke AH, Bewig B, Haverich A., Bronchoalveolar lavage in lung transplantation. State of the art. Clin Transplant 1999; 13: 131-157.
22. + T cells and their role in health and disease. Immunology 2011; 134: 17-32.
23. Stewart S, Fishbein MC, Snell GI, et al. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant 2007; 26: 1229-1242.
24. Chambers JM, Cleveland WS, Kleiner B, Tukey PA., Graphical methods for data analysis. Belmont, CA: Wadsworth & Boston, MA: Duxbury Press, 1983.
25. Liang K, Zeger SL., Longitudinal data analysis using generalized linear models. Biometrika 1986; 73: 13-22.
26. Gregson AL, Hoji A, Saggar R, et al. Bronchoalveolar immunologic profile of acute human lung transplant allograft rejection. Transplantation 2008; 85: 1056-1059.
27. Swanson SJ, Mentzer SJ, Reilly JJ, et al. Surveillance transbronchial lung biopsies: Implication for survival after lung transplantation. J Thorac Cardiovasc Surg 2000; 119: 27-38.
28. Beilke JN, Kuhl NR, Van Kaer L, Gill RG., NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 2005; 11: 1059-1065.
29. Yu G, Xu X, Vu MD, Kilpatrick ED, Li XC., NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 2006; 203: 1851-1858.
30. Jungraithmayr W, Codarri L, Bouchaud G, et al. Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells. Am J Respir Crit Care Med 2013; 187: 1349-1359.
31. Kunert K, Seiler M, Mashreghi MF, et al. KIR/HLA ligand incompatibility in kidney transplantation. Transplantation 2007; 84: 1527-1533.
32. Vampa ML, Norman PJ, Burnapp L, Vaughan RW, Sacks SH, Wong W., Natural killer-cell activity after human renal transplantation in relation to killer immunoglobulin-like receptors and human leukocyte antigen mismatch. Transplantation 2003; 76: 1220-1228.
33. Kwakkel-van Erp JM, van de Graaf EA, Paantjens AW, et al. The killer immunoglobulin-like receptor (KIR) group A haplotype is associated with bronchiolitis obliterans syndrome after lung transplantation. J Heart Lung Transplant 2008; 27: 995-1001.
34. + T cells that are CD25POS and FoxP3NEG. Eur J Immunol 2012; 42: 1893-1905.
35. Neujahr DC, Cardona AC, Ulukpo O, et al. Dynamics of human regulatory T cells in lung lavages of lung transplant recipients. Transplantation 2009; 88: 521-527.
36. Taubert R, Pischke S, Schlue J, et al. Enrichment of regulatory T cells in acutely rejected human liver allografts. Am J Transplant 2012; 12: 3425-3436.