A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.

Nature chemical biology

Volumn 10, Issue 2, 2014, Pages 127-132

  Levinson, Nicholas M ^a   Boxer, Steven G ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; BOSUTINIB; NITRILE; PROTEIN TYROSINE KINASE; QUINOLINE DERIVATIVE; WATER;

AMINO ACID SUBSTITUTION; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; HYDROGEN BOND; METABOLISM; NUCLEOTIDE SEQUENCE;

AMINO ACID SUBSTITUTION; ANILINE COMPOUNDS; CONSERVED SEQUENCE; HUMANS; HYDROGEN BONDING; MODELS, BIOLOGICAL; NITRILES; QUINOLINES; SRC-FAMILY KINASES; SUBSTRATE SPECIFICITY; WATER;

EID: 84897114242     PISSN: None     EISSN: 15524469     Source Type: None    
DOI: 10.1038/nchembio.1404     Document Type: Article

References (0)