Red cell distribution width is associated with mortality in kidney transplant recipients

International Urology and Nephrology

Volumn 46, Issue 3, 2014, Pages 641-651

  Mucsi, Istvan ^a,b   Ujszaszi, Akos ^a,c   Czira, Maria E ^a   Novak, Marta ^a,d   Molnar, Miklos Z ^c,d  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b ROYAL VICTORIA HOSPITAL   (Canada)

^c HARBOR UCLA MEDICAL CENTER   (United States)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Kidney transplantation; Mortality; Red cell distribution width

Indexed keywords

ADULT; ARTICLE; BLOOD CELL COUNT; DIABETIC PATIENT; ERYTHROCYTE SHAPE; FEMALE; GRAFT RECIPIENT; HUMAN; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORBIDITY; MORTALITY; PARAMETERS; RED CELL DISTRIBUTION WIDTH; RISK ASSESSMENT; BLOOD; MEAN CORPUSCULAR VOLUME; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY;

ERYTHROCYTE INDICES; FEMALE; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES;

EID: 84897108449     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-013-0530-z     Document Type: Article

References (46)

1. Evans TC, Jehle D (1991) The red blood cell distribution width. J Emerg Med 9(Suppl 1):71-74
2. Allen LA, Felker GM, Mehra MR, Chiong JR, Dunlap SH, Ghali JK, Lenihan DJ, Oren RM, Wagoner LE, Schwartz TA, Adams KF Jr (2010) Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J Cardiac Fail 16(3):230-238. doi:10.1016/j.cardfail.2009.11.003
3. Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, Swedberg K, Wang D, Yusuf S, Michelson EL, Granger CB, Investigators C (2007) Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 50(1):40-47. doi:10.1016/j.jacc.2007.02.067 (Pubitemid 46963527)
4. Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M, The Cholesterol and Recurrent Events (CARE) Trial Investigators (2008) Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 117(2):163-168. doi:10.1161/CIRCULATIONAHA.107. 727545
5. Cavusoglu E, Chopra V, Gupta A, Battala VR, Poludasu S, Eng C, Marmur JD (2010) Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography. Int J Cardiol 141(2):141-146. doi:10.1016/j.ijcard.2008.11.187
6. Dabbah S, Hammerman H, Markiewicz W, Aronson D (2010) Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol 105(3):312-317. doi:10.1016/j.amjcard.2009.09.027
7. Oh HJ, Park JT, Kim JK, Yoo DE, Kim SJ, Han SH, Kang SW, Choi KH, Yoo TH (2012) Red blood cell distribution width is an independent predictor of mortality in acute kidney injury patients treated with continuous renal replacement therapy. Nephrol Dial Transpl 27(2):589-594. doi:10.1093/ndt/gfr307
8. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM (2009) Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med 169(5):515-523. doi:10.1001/archinternmed.2009.11
9. Perlstein TS, Weuve J, Pfeffer MA, Beckman JA (2009) Red blood cell distribution width and mortality risk in a community-based prospective cohort. Arch Intern Med 169(6):588-594. doi:10.1001/archinternmed.2009.55
10. Pascual-Figal DA, Bonaque JC, Manzano-Fernandez S, Fernandez A, Garrido IP, Pastor-Perez F, Lax A, Valdes M, Januzzi JL (2011) Red blood cell distribution width predicts new-onset anemia in heart failure patients. Int J Cardiol. doi:10.1016/j.ijcard.2011.04.018
11. Emans ME, van der Putten K, van Rooijen KL, Kraaijenhagen RJ, Swinkels D, van Solinge WW, Cramer MJ, Doevendans PA, Braam B, Gaillard CA (2011) Determinants of red cell distribution width (RDW) in cardiorenal patients: RDW is not related to erythropoietin resistance. J Cardiac Fail 17(8):626-633. doi:10.1016/j.cardfail.2011.04.009
12. Forhecz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohaszka Z, Janoskuti L (2009) Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 158(4):659-666. doi:10.1016/j.ahj.2009.07.024
13. Molnar MZ, Czira M, Ambrus C, Szeifert L, Szentkiralyi A, Beko G, Rosivall L, Remport A, Novak M, Mucsi I (2007) Anemia is associated with mortality in kidney-transplanted patients - a prospective cohort study. Am J Transpl 7(4):818-824. doi:10.1111/j.1600-6143.2006.01727.x (Pubitemid 46481205)
14. Remport A, Molnar MZ, Ambrus C, Keszei A, Torok S, Vamos EP, Kiss I, Jaray J, Novak M, Rosivall L, Mucsi I (2010) Impaired renal function is associated with mortality in kidney-transplanted patients. Int Urol Nephrol 42(3):799-809. doi:10.1007/s11255-009-9651-9
15. Molnar MZ, Czira ME, Rudas A, Ujszaszi A, Lindner A, Fornadi K, Kiss I, Remport A, Novak M, Kennedy SH, Rosivall L, Kovesdy CP, Mucsi I (2011) Association of the malnutrition-inflammation score with clinical outcomes in kidney transplant recipients. Am J Kidney Dis 58(1):101-108. doi:10.1053/j.ajkd.2010.11.027
16. Molnar MZ, Tabak AG, Alam A, Czira ME, Rudas A, Ujszaszi A, Beko G, Novak M, Kalantar-Zadeh K, Kovesdy CP, Mucsi I (2011) Serum erythropoietin level and mortality in kidney transplant recipients. Clin J Am Soc Nephrol 6(12):2879-2886. doi:10.2215/CJN.05590611
17. Kovesdy CP, Mucsi I, Czira ME, Rudas A, Ujszaszi A, Rosivall L, Kim SJ, Wolf M, Molnar MZ (2011) Association of serum phosphorus level with anemia in kidney transplant recipients. Transplantation 91(8):875-882. doi:10.1097/TP.0b013e3182111edf
18. Molnar MZ, Czira ME, Rudas A, Ujszaszi A, Haromszeki B, Kosa JP, Lakatos P, Beko G, Sarvary E, Varga M, Fornadi K, Novak M, Rosivall L, Kiss I, Remport A, Goldsmith DJ, Kovesdy CP, Mucsi I (2011) Association between the malnutrition-inflammation score and post-transplant anaemia. Nephrol Dial Transpl 26(6):2000-2006
19. Kovesdy CP, Czira ME, Rudas A, Ujszaszi A, Rosivall L, Novak M, Kalantar-Zadeh K, Molnar MZ, Mucsi I (2010) Body mass index, waist circumference and mortality in kidney transplant recipients. Am J Transpl 10(12):2644-2651. doi:10.1111/j.1600-6143.2010.03330.x
20. Kovesdy CP, Molnar MZ, Czira ME, Rudas A, Ujszaszi A, Rosivall L, Szathmari M, Covic A, Keszei A, Beko G, Lakatos P, Kosa J, Mucsi I (2010) Associations between serum leptin level and bone turnover in kidney transplant recipients. Clin J Am Soc Nephrol 5(12):2297-2304. doi:10.2215/CJN.03520410
21. Molnar MZ, Keszei A, Czira ME, Rudas A, Ujszaszi A, Haromszeki B, Kosa JP, Lakatos P, Sarvary E, Beko G, Fornadi K, Kiss I, Remport A, Novak M, Kalantar-Zadeh K, Kovesdy CP, Mucsi I (2010) Evaluation of the malnutrition-inflammation score in kidney transplant recipients. Am J Kidney Dis 56(1):102-111. doi:10.1053/j.ajkd.2010.02.350
22. Jassal SV, Schaubel DE, Fenton SS (2005) Baseline comorbidity in kidney transplant recipients: a comparison of comorbidity indices. Am J Kidney Dis 46(1):136-142 (Pubitemid 40848442)
23. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150(9):604-612
24. Fine J, Gray R (1999) A proportional hazards model for subdistribution of a competing risk. J Am Stat Assoc 94:496-509
25. Pencina MJ, D'Agostino RB Sr, D'Agostino RB Jr, Vasan RS (2008) Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Statistics in medicine 27(2):157-172; discussion 207-112. doi:10.1002/sim.2929
26. Ani C, Ovbiagele B (2009) Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 277(1-2):103-108. doi:10.1016/j.jns.2008.10.024
27. Ye Z, Smith C, Kullo IJ (2011) Usefulness of red cell distribution width to predict mortality in patients with peripheral artery disease. Am J Cardiol 107(8):1241-1245. doi:10.1016/j.amjcard.2010.12.023
28. Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB (2011) Red cell distribution width and all-cause mortality in critically ill patients. Crit Care Med 39(8):1913-1921. doi:10.1097/CCM.0b013e31821b85c6
29. Braun E, Domany E, Kenig Y, Mazor Y, Makhoul BF, Azzam ZS (2011) Elevated red cell distribution width predicts poor outcome in young patients with community acquired pneumonia. Crit Care 15(4):R194. doi:10.1186/cc10355
30. Van Craenenbroeck EM, Pelle AJ, Beckers PJ, Possemiers NM, Ramakers C, Vrints CJ, Van Hoof V, Denollet J, Conraads VM (2012) Red cell distribution width as a marker of impaired exercise tolerance in patients with chronic heart failure. Eur J Heart Fail 14(1):54-60. doi:10.1093/eurjhf/hfr136
31. Borne Y, Smith JG, Melander O, Hedblad B, Engstrom G (2011) Red cell distribution width and risk for first hospitalization due to heart failure: a population-based cohort study. Eur J Heart Fail 13(12):1355-1361. doi:10.1093/eurjhf/hfr127
32. Patel KV, Semba RD, Ferrucci L, Newman AB, Fried LP, Wallace RB, Bandinelli S, Phillips CS, Yu B, Connelly S, Shlipak MG, Chaves PH, Launer LJ, Ershler WB, Harris TB, Longo DL, Guralnik JM (2010) Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol Ser A 65(3):258-265. doi:10.1093/gerona/glp163
33. Hunziker S, Stevens J, Howell MD (2012) Red cell distribution width and mortality in newly hospitalized patients. Am J Med 125(3):283-291. doi:10.1016/j.amjmed.2011.08.021
34. Molnar MZ, Novak M, Ambrus C, Kovacs A, Pap J, Remport A, Szeifert L, Mucsi I (2005) Anemia in kidney transplanted patients. Clin Transpl 19(6):825-833. doi:10.1111/j.1399-0012.2005.00428.x (Pubitemid 41748739)
35. Vanrenterghem Y, Ponticelli C, Morales JM, Abramowicz D, Baboolal K, Eklund B, Kliem V, Legendre C, Morais Sarmento AL, Vincenti F (2003) Prevalence and management of anemia in renal transplant recipients: a European survey. Am J Transpl 3(7):835-845 (Pubitemid 36827905)
36. Afzali B, Al-Khoury S, Shah N, Mikhail A, Covic A, Goldsmith D (2006) Anemia after renal transplantation. Am J Kidney Dis 48(4):519-536. doi:10.1053/j.ajkd.2006.07.006 (Pubitemid 44425377)
37. Chiari MM, Bagnoli R, De Luca PD, Monti M, Rampoldi E, Cunietti E (1995) Influence of acute inflammation on iron and nutritional status indexes in older inpatients. J Am Geriatr Soc 43(7):767-771
38. Pierce CN, Larson DF (2005) Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion 20(2):83-90 (Pubitemid 40691877)
39. Yesil A, Senates E, Bayoglu IV, Erdem ED, Demirtunc R, Kurdas Ovunc AO (2011) Red cell distribution width: a novel marker of activity in inflammatory bowel disease. Gut liver 5(4):460-467. doi:10.5009/gnl.2011.5.4.460
40. Maruyama S, Hirayama C, Yamamoto S, Koda M, Udagawa A, Kadowaki Y, Inoue M, Sagayama A, Umeki K (2001) Red blood cell status in alcoholic and non-alcoholic liver disease. J Lab Clin Med 138(5):332-337. doi:10.1067/mlc. 2001.119106 (Pubitemid 33066155)
41. Ozkalemkas F, Ali R, Ozkocaman V, Ozcelik T, Ozan U, Ozturk H, Kurt E, Evrensel T, Yerci O, Tunali A (2005) The bone marrow aspirate and biopsy in the diagnosis of unsuspected nonhematologic malignancy: a clinical study of 19 cases. BMC cancer 5:144. doi:10.1186/1471-2407-5-144
42. Spell DW, Jones DV Jr, Harper WF, David Bessman J (2004) The value of a complete blood count in predicting cancer of the colon. Cancer Detect Prev 28(1):37-42. doi:10.1016/j.cdp.2003.10.002 (Pubitemid 39403832)
43. Lappe JM, Horne BD, Shah SH, May HT, Muhlestein JB, Lappe DL, Kfoury AG, Carlquist JF, Budge D, Alharethi R, Bair TL, Kraus WE, Anderson JL (2011) Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population. Clinica chimica acta 412(23-24):2094-2099. doi:10.1016/j.cca.2011.07.018
44. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC (2008) Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients. Scand J Clin Lab Invest 68(8):745-748. doi:10.1080/00365510802213550
45. Afonso L, Zalawadiya SK, Veeranna V, Panaich SS, Niraj A, Jacob S (2011) Relationship between red cell distribution width and microalbuminuria: a population-based study of multiethnic representative US adults. Nephron Clin Pract 119(4):c277-c282. doi:10.1159/000328918
46. Foley RN, Parfrey PS, Sarnak MJ (1998) Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32(5 Suppl 3):S112-S119