Risk of ischemic stroke and decreased serum bilirubin levels: Is there a causal link?

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 4, 2014, Pages 702-704

  Targher, Giovanni ^a  

^a UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

bilirubin; Editorials; risk factors; stroke

Indexed keywords

BILIRUBIN; BILIRUBIN GLUCURONIDE; BILIVERDIN; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; HEME OXYGENASE; LIPID; LIVER ENZYME; STEROID HORMONE;

BILIRUBIN BLOOD LEVEL; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; ERYTHROCYTE; GENETIC VARIABILITY; GLUCURONIDATION; HEART INFARCTION; HUMAN; LIPOPHILICITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; RISK FACTOR; VASCULARIZATION;

BILIRUBIN; EDITORIALS; RISK FACTORS; STROKE;

BILIRUBIN; CEREBRAL INFARCTION; FEMALE; HUMANS; MALE;

EID: 84897103226     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303279     Document Type: Review

References (28)

1. Vítek L, Schwertner HA. The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv Clin Chem. 2007;43:1-57.
2. Franchini M, Targher G, Lippi G. Serum bilirubin levels and cardiovascular disease risk: a Janus Bifrons? Adv Clin Chem. 2010;50:47-63.
3. Borucki K, Weikert C, Fisher E, Jakubiczka S, Luley C, Westphal S, Dierkes J. Haplotypes in the UGT1A1 gene and their role as genetic determinants of bilirubin concentration in healthy German volunteers. Clin Biochem. 2009;42:1635-1641.
4. Breimer LH, Wannamethee G, Ebrahim S, Shaper AG. Serum bilirubin and risk of ischemic heart disease in middle-Aged British men. Clin Chem. 1995;41:1504-1508.
5. Djoussé L, Levy D, Cupples LA, Evans JC, D'Agostino RB, Ellison RC. Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol. 2001;87:1196-1200; A4, 7.
6. Novotný L, Vítek L. Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-Analysis of published studies. Exp Biol Med (Maywood). 2003;228:568-571.
7. Perlstein TS, Pande RL, Beckman JA, Creager MA. Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. Arterioscler Thromb Vasc Biol. 2008;28:166-172.
8. Fulks M, Stout RL, Dolan VF. Mortality associated with bilirubin levels in insurance applicants. J Insur Med. 2009;41:49-53.
9. Sung KC, Shin J, Lim YH, Wild SH, Byrne CD. Relation of conjugated bilirubin concentrations to the presence of coronary artery calcium. Am J Cardiol. 2013;112:1873-1879.
10. Horsfall LJ, Nazareth I, Petersen I. Cardiovascular events as a function of serum bilirubin levels in a large, statin-treated cohort. Circulation. 2012;126:2556-2564.
11. Perlstein TS, Pande RL, Creager MA, Weuve J, Beckman JA. Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004. Am J Med. 2008;121:781-788.e1.
12. Oda E, Kawai R. A possible cross-sectional association of serum total bili-rubin with coronary heart disease and stroke in a Japanese health screening population. Heart Vessels. 2012;27:29-36.
13. Kimm H, Yun JE, Jo J, Jee SH. Low serum bilirubin level as an independent predictor of stroke incidence: a prospective study in Korean men and women. Stroke. 2009;40:3422-3427.
14. Pineda S, Bang OY, Saver JL, Starkman S, Yun SW, Liebeskind DS, Kim D, Ali LK, Shah SH, Ovbiagele B. Association of serum bilirubin with ischemic stroke outcomes. J Stroke Cerebrovasc Dis. 2008;17:147-152.
15. Xu T, Zhang J, Xu T, Liu W, Kong Y, Zhang Y. Association of serum bilirubin with stroke severity and clinical outcomes. Can J Neurol Sci. 2013;40:80-84.
16. Luo Y, Li J, Zhang J, Xu Y. Elevated bilirubin after acute ischemic stroke linked to the stroke severity. Int J Dev Neurosci. 2013;31:634-638.
17. Zhang B, Zhang W, Li X, Pu S, Yin J, Yang N, Yi Y, Gao Q, Gao C. Admission markers predict lacunar and non-lacunar stroke in young patients. Thromb Res. 2011;128:14-17.
18. Li R-Y, Cao Z-G, Zhang J-R, Li Y, Wang R-T. Decreased serum biliru-bin is associated with silent cerebral infarction. Arterioscler Thromb Vasc Biol. 2014;34:946-951.
19. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM; Rotterdam Scan Study. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke. 2003;34:1126-1129.
20. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003;348:1215-1222.
21. Lin JP, O'Donnell CJ, Schwaiger JP, Cupples LA, Lingenhel A, Hunt SC, Yang S, Kronenberg F. Association between the UGT1A1*28 allele, bili-rubin levels, and coronary heart disease in the Framingham Heart Study. Circulation. 2006;114:1476-1481.
22. Bosma PJ, van der Meer IM, Bakker CT, Hofman A, Paul-Abrahamse M, Witteman JC. UGT1A1*28 allele and coronary heart disease: the Rotterdam Study. Clin Chem. 2003;49:1180-1181.
23. Gajdos V, Petit FM, Perret C, Mollet-Boudjemline A, Colin P, Capel L, Nicaud V, Evans A, Arveiler D, Parisot F, Francoual J, Genin E, Cambien F, Labrune P. Further evidence that the UGT1A1*28 allele is not associated with coronary heart disease: The ECTIM Study. Clin Chem. 2006;52:2313-2314.
24. Ekblom K, Marklund SL, Jansson JH, Osterman P, Hallmans G, Weinehall L, Hultdin J. Plasma bilirubin and UGT1A1*28 are not protective factors against frst-time myocardial infarction in a prospective, nested case-referent setting. Circ Cardiovasc Genet. 2010;3:340-347.
25. Ekblom K, Marklund SL, Johansson L, Osterman P, Hallmans G, Weinehall L, Wiklund PG, Hultdin J. Bilirubin and UGT1A1*28 are not associated with lower risk for ischemic stroke in a prospective nested case-referent setting. Cerebrovasc Dis. 2010;30:590-596.
26. Vítek L, Jirsa M, Brodanová M, Kalab M, Marecek Z, Danzig V, Novotný L, Kotal P. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. Atherosclerosis. 2002;160:449-456.
27. McCarty MF. "Iatrogenic Gilbert syndrome"-A strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Med Hypotheses. 2007;69:974-994.
28. Peterson SJ, Frishman WH, Abraham NG. Targeting heme oxygenase: therapeutic implications for diseases of the cardiovascular system. Cardiol Rev. 2009;17:99-111.