Effectiveness of massive transfusion protocols on mortality in trauma: A systematic review and meta-analysis

ANZ Journal of Surgery

Volumn 83, Issue 12, 2013, Pages 918-923

  Mitra, Biswadev ^a,b   O'Reilly, Gerard ^a,b   Cameron, Peter A ^a,b   Zatta, Amanda ^b   Gruen, Russell L ^a  

^a ALFRED HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Blood component transfusion; Blood transfusion; Emergency medicine; Fresh frozen plasma; Resuscitation

Indexed keywords

FRESH FROZEN PLASMA;

ARTIFICIAL VENTILATION; BLEEDING; BLOOD COMPONENT THERAPY; BLOOD TRANSFUSION; CLINICAL PROTOCOL; EMERGENCY MEDICINE; HUMAN; INJURY; LENGTH OF STAY; META ANALYSIS; METHODOLOGY; MORTALITY; RESUSCITATION; REVIEW; STANDARD; STATISTICS; THROMBOCYTE TRANSFUSION; TREATMENT OUTCOME;

BLOOD COMPONENT TRANSFUSION; BLOOD TRANSFUSION; EMERGENCY MEDICINE; FRESH FROZEN PLASMA; RESUSCITATION;

BLOOD TRANSFUSION; CLINICAL PROTOCOLS; HEMORRHAGE; HUMANS; LENGTH OF STAY; PLATELET TRANSFUSION; RESPIRATION, ARTIFICIAL; TREATMENT OUTCOME; WOUNDS AND INJURIES;

EID: 84897098360     PISSN: 14451433     EISSN: 14452197     Source Type: Journal    
DOI: 10.1111/ans.12417     Document Type: Review

References (29)

1. Kauvar D, Wade C. The epidemiology and modern management of traumatic hemorrhage: US and international perspectives. Crit. Care 2005; 9: S1-9.
2. Gruen R, Brohi K, Schreiber M etal. Haemorrhage control in severely injured patients. Lancet 2012; 380: 1099-1108.
3. Brohi K, Cohen M, Davenport R. Acute coagulopathy of trauma: mechanism, identification and effect. Curr. Opin. Crit. Care 2007; 13: 680-685.
4. Brohi K, Cohen M, Ganter M, Matthay M, Mackersie R, Pittet J. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann. Surg. 2007; 245: 812-818.
5. Schuster K, Davis K, Lui F, Maerz L, Kaplan L. The status of massive transfusion protocols in United States trauma centers: massive transfusion or massive confusion? Transfusion 2010; 50: 1545-1551.
6. Sihler K, Napolitano L. Complications of massive transfusion. Chest 2010; 137: 209-220.
7. Gilbert E, Lowenstein S, Koziol-McLain J, Barta D, Steiner J. Chart reviews in emergency medicine research: where are the methods? Ann. Emerg. Med. 1996; 27: 305-308.
8. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control. Clin. Trials 1986; 7: 177-188.
9. Higgins JP, Thompson S. Quantifying heterogeneity in a meta-analysis. Stat. Med. 2002; 21: 1539-1558.
10. Cochran W. The combination of estimates from different experiments. Biometrics 1954; 10: 101-129.
11. Johansson P, Stensballe J. Effect of haemostatic control resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sang. 2008; 96: 111-118.
12. Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J. Trauma 2009; 66: 41-48; discussion 48-49.
13. Cotton B, Gunter O, Isbell J etal. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J. Trauma 2008; 64: 1177-1182.
14. Gunter OL Jr, Au BK, Isbell JM, Mowery NT, Young PP, Cotton BA. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J. Trauma 2008; 65: 527-534.
15. Dente C, Shaz B, Nicholas J etal. Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center. J. Trauma 2009; 66: 1616-1624.
16. Shaz B, Dente C, Nicholas J etal. Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion 2010; 50: 493-500.
17. Khan S, Allard S, Weaver A, Barber C, Davenport R, Brohi K. A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 2013; 44: 587-592.
18. Riskin D, Tsai T, Riskin L etal. Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J. Am. Coll. Surg. 2009; 209: 198-205.
19. O'Keeffe T, Refaai M, Tchorz K, Forestner J, Sarode R. A massive transfusion protocol to decrease blood component use and costs. Arch. Surg. 2008; 143: 686-690.
20. Simmons J, White C, Eastridge B, Mace J, Wade C, Blackbourne L. Impact of policy change on US Army combat transfusion practices. J. Trauma 2010; 69: S75-80.
21. Dirks J, Jørgensen H, Jensen C, Ostrowski S, Johansson P. Blood product ratio in acute traumatic coagulopathy - effect on mortality in a Scandinavian level 1 trauma centre. Scand. J. Trauma Resusc. Emerg. Med. 2010; 18: 65.
22. Sisak K, Soeyland K, McLeod M etal. Massive transfusion in trauma: blood product ratios should be measured at 6 hours. ANZ J. Surg. 2012; 82: 161-167.
23. Sinha R, Roxby D, Bersten A. Experience with a massive transfusion protocol in the management of massive haemorrhage. Transfus. Med. 2013; 23: 108-113.
24. Sisak K, Manolis M, Hardy BM, Enninghorst N, Bendinelli C, Balogh ZJ. Acute transfusion practice during trauma resuscitation: who, when, where and why? Injury 2013; 44: 581-586.
25. Rajasekhar A, Gowing R, Zarychanski R etal. Survival of trauma patients after massive red blood cell transfusion using a high or low red blood cell to plasma transfusion ratio. Crit. Care Med. 2011; 39: 1507-1513.
26. Mitra B, Mori A, Cameron PA, Fitzgerald M, Paul E, Street A. Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation. Injury 2010; 41: 35-39.
27. Cotton B, Dossett L, Au B, Nunez T, Robertson A, Young P. Room for (performance) improvement: provider-related factors associated with poor outcomes in massive transfusion. J. Trauma 2009; 67: 1004-1012.
28. Snyder CW, Weinberg JA, McGwin G Jr etal. The relationship of blood product ratio to mortality: survival benefit or survival bias? J. Trauma 2009; 66: 358-362; discussion 362-354.
29. Dressler A, Finck C, Carroll C, Bonanni C, Spinella P. Use of a massive transfusion protocol with hemostatic resuscitation for severe intraoperative bleeding in a child. J. Pediatr. Surg. 2010; 45: 1530-1533.