Colchicine for prevention of atrial fibrillation recurrence after pulmonary vein isolation: Mid-term efficacy and effect on quality of life

Heart Rhythm

Volumn 11, Issue 4, 2014, Pages 620-628

  Deftereos, Spyridon ^a,b   Giannopoulos, Georgios ^a,b   Efremidis, Michael ^c   Kossyvakis, Charalampos ^a   Katsivas, Apostolos ^d   Panagopoulou, Vasiliki ^a   Papadimitriou, Charalampos ^a   Karageorgiou, Sofia ^a   Doudoumis, Konstantinos ^a   Raisakis, Konstantinos ^a   Kaoukis, Andreas ^a   Alexopoulos, Dimitrios ^e   Manolis, Antonis S ^f   Stefanadis, Christodoulos ^f   Cleman, Michael W ^b  

^a G GENNIMATAS GENERAL HOSPITAL   (Greece)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EVANGELISMOS HOSPITAL   (Greece)

^d RED CROSS HOSPITAL   (Greece)

^e UNIVERSITY OF PATRAS   (Greece)

^f UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Antiinflammatory; Atrial fibrillation; C reactive protein; Colchicine; Inflammation; Interleukin 6

Indexed keywords

C REACTIVE PROTEIN; COLCHICINE; INTERLEUKIN 6; PLACEBO; BIOLOGICAL MARKER;

ARTICLE; BODY MASS; CLINICAL EFFECTIVENESS; CLINICAL PROTOCOL; CORONARY ARTERY DISEASE; DIARRHEA; FEMALE; FOLLOW UP; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HOSPITALIZATION; HUMAN; INTENTION TO TREAT ANALYSIS; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; NAUSEA; NONPARAMETRIC TEST; PATIENT MONITORING; PRIORITY JOURNAL; PULMONARY VEIN ISOLATION; QUALITY OF LIFE; RADIOFREQUENCY ABLATION; RANDOMIZED CONTROLLED TRIAL; RECURRENCE FREE SURVIVAL; RECURRENCE RISK; RECURRENT DISEASE; SURVIVAL; ATRIAL FIBRILLATION; CONTROLLED STUDY; MIDDLE AGED; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; PULMONARY VEIN; RISK REDUCTION; SURGERY; ABLATION THERAPY; ADULT; CLINICAL ARTICLE; DIABETES MELLITUS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; HYPERTENSION; PAROXYSMAL ATRIAL FIBRILLATION; QUALITY OF LIFE ASSESSMENT; RISK FACTOR; STATISTICAL SIGNIFICANCE;

ATRIAL FIBRILLATION; COLCHICINE; FEMALE; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); POSTOPERATIVE CARE; PULMONARY VEINS; QUALITY OF LIFE; RECURRENCE; RISK REDUCTION BEHAVIOR;

EID: 84897072911     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.02.002     Document Type: Article

References (24)

1. Wann LS, Curtis AB, January CT, et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (Updating the 2006 Guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Heart Rhythm 2011;8:157-176.
2. Haïssaguerre M, Jaïs P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Métayer P, Clémenty J. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998;339:659-666. (Pubitemid 28402090)
3. Koyama T, Sekiguchi Y, Tada H, et al. Comparison of characteristics and significance of immediate vs early vs no recurrence of atrial fibrillation after catheter ablation. Am J Cardiol 2009;103:1249-1254.
4. Deftereos S, Giannopoulos G, Kossyvakis C, et al. Colchicine for prevention of early atrial fibrillation recurrence after pulmonary vein isolation: a randomized controlled study. J Am Coll Cardiol 2012;60:1790-1796.
5. Molad Y. Update on colchicine and its mechanism of action. Curr Rheumatol Rep 2002;4:252-256.
6. Deftereos S, Giannopoulos G, Papoutsidakis N, Panagopoulou V, Kossyvakis C, Raisakis K, Cleman MW, Stefanadis C. Colchicine and the heart: pushing the envelope. J Am Coll Cardiol 2013;62:1817-1825.
7. O'Keefe JH Jr, McCallister BD, Bateman TM, Kuhnlein DL, Ligon RW, Hartzler GO. Ineffectiveness of colchicine for the prevention of restenosis after coronary angioplasty. J Am Coll Cardiol 1992;19:1597-1600.
8. Deftereos S, Giannopoulos G, Raisakis K, et al. Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients. J Am Coll Cardiol 2013;61:1679-1685.
9. Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL. Low-dose colchicine for secondary prevention of cardiovascular disease. J Am Coll Cardiol 2013;61:404-410.
10. McCabe JM, Smith LM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE, Marcus GM. Protracted CRP elevation after atrial fibrillation ablation. Pacing Clin Electrophysiol 2008;31:1146-1151.
11. Ks response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules. Cardiovasc Res 2008;79:427-435.
12. Parker KK, Taylor LK, Atkinson JB, Hansen DE, Wikswo JP. The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias. Eur J Pharmacol 2001;417:131-140. (Pubitemid 32299876)
13. Lemola K, Hall B, Cheung P, Good E, Han J, Tamirisa K, Chugh A, Bogun F, Pelosi F Jr, Morady F, Oral H. Mechanisms of recurrent atrial fibrillation after pulmonary vein isolation by segmental ostial ablation. Heart Rhythm 2004;1:197-202. (Pubitemid 38878239)
14. Nilsson B, Chen X, Pehrson S, Køber L, Hilden J, Svendsen JH. Recurrence of pulmonary vein conduction and atrial fibrillation after pulmonary vein isolation for atrial fibrillation: a randomized trial of the ostial vs the extraostial ablation strategy. Am Heart J 2006;152:537. e1-e8.
15. Kowalski M, Grimes MM, Perez FJ, Kenigsberg DN, Koneru J, Kasirajan V, Wood MA, Ellenbogen KA. Histopathologic characterization of chronic radiofrequency ablation lesions for pulmonary vein isolation. J Am Coll Cardiol 2012;59:930-938.
16. Arya A, Hindricks G, Sommer P, Huo Y, Bollmann A, Gaspar T, Bode K, Husser D, Kottkamp H, Piorkowski C. Long-term results and the predictors of outcome of catheter ablation of atrial fibrillation using steerable sheath catheter navigation after single procedure in 674 patients. Europace 2010;12:173-180.
17. Lellouche N, Jaïs P, Nault I, et al. Early recurrences after atrial fibrillation ablation: prognostic value and effect of early reablation. J Cardiovasc Electrophysiol 2008;19:599-605. (Pubitemid 351843403)
18. Leong-Sit P, Roux JF, Zado E, et al. Antiarrhythmics after ablation of atrial fibrillation (5A Study): six-month follow-up study. Circ Arrhythm Electrophysiol 2011;4:11-14.
19. Andrade JG, Macle L, Khairy P, et al. Incidence and significance of early recurrences associated with different ablation strategies for AF: a STAR-AF substudy. J Cardiovasc Electrophysiol 2012;23:1295-1301.
20. Koyama T, Tada H, Sekiguchi Y, et al. Prevention of atrial fibrillation recurrence with corticosteroids after radiofrequency catheter ablation: a randomized controlled trial. J Am Coll Cardiol 2010;56:1463-1472.
21. Platonov PG, Mitrofanova LB, Orshanskaya V, Ho SY. Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age. J Am Coll Cardiol 2011;58:2225-2232.
22. Nikolaidis N, Kountouras J, Giouleme O, Tzarou V, Chatzizisi O, Patsiaoura K, Papageorgiou A, Leontsini M, Eugenidis N, Zamboulis C. Colchicine treatment of liver fibrosis. Hepatogastroenterology 2006;53:281-285.
23. Fichtner S, Deisenhofer I, Kindsmüller S, et al. Prospective assessment of short and long-term quality of life after ablation for atrial fibrillation. J Cardiovasc Electrophysiol 2012;23:121-127.
24. Marcus GM, Hsu JC. Colchicine after pulmonary vein isolation to prevent the early recurrence of atrial fibrillation: mollifying an inflammatory response? J Am Coll Cardiol 2012;60:1797-1798.