Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)n in the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis

Neuropathology

Volumn 33, Issue 6, 2013, Pages 600-611

  Niimi, Yusuke ^a   Takahashi, Makoto ^a   Sugawara, Emiko ^a   Umeda, Shigeaki ^a   Obayashi, Masato ^a   Sato, Nozomu ^a   Ishiguro, Taro ^a   Higashi, Miwa ^a   Eishi, Yoshinobu ^a   Mizusawa, Hidehiro ^a   Ishikawa, Kinya ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cerebellar ataxia; Neurodegeneration; Purkinje cell; Repeat expansion; RNA foci

Indexed keywords

BRAIN EXPRESSED ASSOCIATED WITH NEDD4 1; PROTEIN; THYMIDINE KINASE; THYMIDINE KINASE 2; UNCLASSIFIED DRUG;

ADULT; AGED; ANTERIOR HORN CELL; ARTICLE; ASPIRATION PNEUMONIA; AUTOPSY; BRAIN CORTEX; BRAIN STEM; CELL CULTURE; CELL DEATH; CELL NUCLEUS; CELL VIABILITY; CEREBELLAR ATAXIA; CEREBELLUM ATROPHY; CEREBELLUM DEGENERATION; CONTROLLED STUDY; CYTOTOXICITY; DENTATE NUCLEUS; EMACIATION; FLUORESCENCE IN SITU HYBRIDIZATION; GLIA CELL; GLIOSIS; HEARING IMPAIRMENT; HISTOPATHOLOGY; HUMAN; INFERIOR OLIVE; MALE; MIDDLE AGED; NERVE CELL DEGENERATION; NEUROLOGIC EXAMINATION; NUCLEOTIDE REPEAT; PATHOGENESIS; PENTA NUCLEOTIDE REPEAT; PERIPHERAL EDEMA; PRIORITY JOURNAL; PURKINJE CELL; RETROPERITONEUM; RNA FOCI; RNA STRUCTURE; SENILE PLAQUE; SPINAL CORD; SPINOCEREBELLAR ATAXIA TYPE 31; STOMACH CANCER; VERY ELDERLY; WALKING DIFFICULTY;

CEREBELLAR ATAXIA; NEURODEGENERATION; PURKINJE CELL; REPEAT EXPANSION; RNA FOCI;

AGE OF ONSET; AGED; AGED, 80 AND OVER; CELL NUCLEUS; DNA REPEAT EXPANSION; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; NUCLEIC ACID CONFORMATION; PURKINJE CELLS; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SPINOCEREBELLAR ATAXIAS; TRANSFECTION;

EID: 84897057190     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/neup.12032     Document Type: Article

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