Evaluation and SAR analysis of the cytotoxicity of tanshinones in colon cancer cells

Chinese Journal of Natural Medicines

Volumn 12, Issue 3, 2014, Pages 167-171

  Wang, Lin ^b   Liu, An ^c   Zhang, Fei Long ^a   Yeung, John H K ^b   Li, Xu Qin ^a   Cho, Chi Hin ^b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY BEIJING   (China)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Colon cancer; Cytotoxicity; SAR analysis; Synthetic derivatives; Tanshinones

Indexed keywords

2,2' (PHENYLMETHYLENE) BIS( 1,6,6 TRIMETHYL 6,7,8,9 TETRAHYDROPHENANTHRO[1,2 B]FURAN 10,11 DIONE); 2,2' [( 4 HYDROXYPHENYL)METHYLENENE] BIS( 1,6,6 TRIMETHYL 6,7,8,9 TETRAHYDROPHENANTHRO[1,2 B]FURAN 10,11 DIONE); ANTINEOPLASTIC AGENT; DOXORUBICIN; FLUOROURACIL; OXALIPLATIN; PLANT MEDICINAL PRODUCT; PROTEIN P53; TANSHINONE DERIVATIVE; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG; ABIETANE DERIVATIVE; HERBACEOUS AGENT; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MTT ASSAY; STRUCTURE ACTIVITY RELATION; CELL LINE; CHEMISTRY; COLON; COLONIC NEOPLASMS; DRUG EFFECTS; HCT116 CELL LINE; HT 29 CELL LINE; PHYTOTHERAPY; SALVIA MILTIORRHIZA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE; COLON; COLONIC NEOPLASMS; DITERPENES, ABIETANE; DRUGS, CHINESE HERBAL; HCT116 CELLS; HT29 CELLS; HUMANS; PHYTOTHERAPY; SALVIA MILTIORRHIZA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897048295     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(14)60028-5     Document Type: Article

References (17)

1. Gallagher DJ, Kemeny N Metastatic colorectal cancer: from improved survival to potential cure [J]. Oncology 2010, 78(3-4):237-248.
2. Dalerba P, Maccalli C, Casati C, et al. Immunology and immunotherapy of colorectal cancer [J]. Crit Rev Oncol Hematol 2003, 46(1):33-57.
3. Hind D, Tappenden P, Tumur I, et al. The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation [J]. Health Technol Assess 2008, 12(15):1-162.
4. Li-Weber M Targeting apoptosis pathways in cancer by Chinese medicine [J]. Cancer Lett 2013, 332(2):304-312.
5. Wang X, Morris-Natschke SL, Lee KH New developments in the chemistry and biology of the bioactive constituents of Tanshen [J]. Med Res Rev 2007, 27(1):133-148.
6. Gong Y, Li YL, Lu Y, et al. Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice [J]. Int J Cancer 2011, 129(5):1042-1052.
7. Dong Y, Morris-Natschke SL, Lee KH Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents [J]. Nat Prod Rep 2011, 28(3):529-542.
8. Su CC, Chen GW, Lin JG Growth inhibition and apoptosis induction by tanshinone I in human colon cancer Colo 205 cells [J]. Int J Mol Med 2008, 22(5):613-618.
9. Su CC, Chen GW, Kang JC, Chan MH Growth inhibition and apoptosis induction by tanshinone IIA in human colon ade- nocarcinoma cells [J]. Planta Med 2008, 74(11):1357-1362.
10. Kim DH, Kundu JK, Surh YJ Redox modulation of p53: mechanisms and functional significance [J]. Mol Carcinog 2011, 50(4):222-234.
11. Liu Y, Bodmer WF Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines [J]. Proc Natl Acad Sci USA 2006, 103:976-981.
12. Qin JK, Bu XZ, Wang YF, et al. Synthesis of 2, 2'-(substituted arylmethylene)bis(1, 6, 6-trimethyl-6, 7, 8, 9- tetrahydrophenanthro [1, 2-b]furan-10, 11-dione) derivatives [J]. Chin Chem Lett 2005, 16(11):1451-1454.
13. Bi YF, Xu HW, Liu XQ, et al. Synthesis and vasodilative activity of tanshinone IIA derivatives [J]. Bioorg Med Chem Lett 2010, 20(16):4892-4894.
14. Watson JL, Hill R, Yaffe PB, et al. Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells [J]. Cancer Lett 2010, 297(1):1-8.
15. Zhang Y, Yuan J, Zhang HY, et al. Natural resistance to apoptosis correlates with resistance to chemotherapy in colorectal cancer cells [J]. Clin Exp Med 2012, 12(2):97-103.
16. Pani G, Bedogni B, Anzevino R, et al. Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells [J]. Cancer Res 2000, 60(16):4654-4660.
17. Zhao ML, Yin JJ, Li ML, et al. QSAR study for cytotoxicity of diterpenoid tanshinones [J]. Interdiscip Sci Comput Life Sci 2011, 3:121-127.