Determinants of peak oxygen uptake in patients with hypertrophic cardiomyopathy: A single-center study

Internal and Emergency Medicine

Volumn 9, Issue 3, 2014, Pages 293-302

  Magrì, Damiano ^a   Agostoni, Piergiuseppe ^b,c   Cauti, Filippo Maria ^a   Musumeci, Beatrice ^a   Egidy Assenza, Gabriele ^a,d   De Cecco, Carlo Nicola ^a   Muscogiuri, Giuseppe ^a   Maruotti, Antonello ^e,f   Ricotta, Agnese ^a   Pagannone, Erika ^a   Marino, Laura ^a   Santini, Daria ^a   Proietti, Giulia ^a   Serdoz, Andrea ^a   Paneni, Francesco ^a,g   Volpe, Massimo ^a,g   Autore, Camillo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF WASHINGTON   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e ROMA TRE UNIVERSITY   (Italy)

^f UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^g IRCCS NEUROMED   (Italy)

Author keywords

Cardiopulmonary exercise test; Chronotropic incompetence; Hypertrophyc cardiomyopathy

Indexed keywords

OXYGEN;

CROSS-SECTIONAL STUDY; EXERCISE TEST; FEMALE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY;

CARDIOMYOPATHY, HYPERTROPHIC; CROSS-SECTIONAL STUDIES; EXERCISE TEST; FEMALE; HUMANS; MALE; MIDDLE AGED; OXYGEN;

EID: 84897022550     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-012-0866-x     Document Type: Article

References (43)

1. Maron BJ, Bonow RO, Cannon RO 3rd, Leon MB, Epstein SE (1987) Hypertrophic cardiomyopathy: interrelations of clinical manifestations, pathophysiology, and therapy (2). N Engl J Med 316: 844-852.
2. Elliott P, McKenna WJ (2004) Hypertrophic cardiomyopathy. Lancet 2004(5): 1881-1891.
3. Olivotto I, Cecchi F, Casey SA et al (2001) Impact of atrial fibrillation on the clinical course of hypertrophic cardiomyopathy. Circulation 104: 2517-2524.
4. Harris KM, Spirito P, Maron MS et al (2006) Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy. Circulation 114: 216-225.
5. Autore C, Bernabò P, Barillà CS, Bruzzi P, Spirito P (2005) The prognostic importance of left ventricular outflow obstruction in hypertrophic cardiomyopathy varies in relation to the severity of symptoms. J Am Coll Cardiol 45: 1076-1080.
6. Varnava AM, Elliott PM, Sharma S, McKenna WJ, Davies MJ (2000) Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart 84: 476-482.
7. Payá E, Marín F, González J et al (2008) Variables associated with contrast-enhanced cardiovascular magnetic resonance in hypertrophic cardiomyopathy: clinical implications. J Card Fail 14: 414-419.
8. Briguori C, Betocchi S, Romano M et al (1999) Exercise capacity in hypertrophic cardiomyopathy depends on left ventricular diastolic function. Am J Cardiol 84: 309-315.
9. Lele SS, Thomson HL, Seo H, Belenkie I, McKenna WJ, Frenneaux MP (1995) Exercise capacity in hypertrophic cardiomyopathy. Role of stroke volume, heart rate, and diastolic filling characteristics. Circulation 92: 2886-2894.
10. Nistri S, Olivotto I, Betocchi S et al (2006) Prognostic significance of left atrial size in patients with hypertrophic cardiomyopathy (from the Italian Registry for Hypertrophic Cardiomyopathy). Am J Cardiol 98: 960-965.
11. Matsumura Y, Elliott P, Virdee, Sorajja P, Doi Y, McKenna WJ (2002) Left ventricular diastolic function assessed using Doppler tissue imaging in patients with hypertrophic cardiomyopathy: relation to symptoms and exercise capacity. Heart 87: 247-251.
12. Magrì D, Palermo P, Cauti FM et al (2012) Chronotropic incompetence and functional capacity in chronic heart failure: no role of beta-blockers and beta-blocker dose. Cardiovasc Ther 30: 100-108.
13. Sharma S, Elliott P, Whyte G et al (2000) Utility of cardiopulmonary exercise in the assessment of clinical determinants of functional capacity in hypertrophic cardiomyopathy. Am J Cardiol 86: 162-168.
14. Efthimiadis GK, Giannakoulas G, Parcharidou DG et al (2011) Chronotropic incompetence and its relation to exercise intolerance in hypertrophic cardiomyopathy. Int J Cardiol 153: 179-184.
15. Spirito P, Bellone P, Harris KM, Bernabo P, Bruzzi P, Maron BJ (2000) Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. N Engl J Med 15: 1778-1785.
16. Lang RM, Bierig M, Devereux RB et al (2005) Recommendation for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standard Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Society of Echocardiograph, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18: 1440-1463.
17. Nagueh SF, Appleton CP, Gillebert TC et al (2009) Recommendation for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 10: 165-193.
18. Joshi S, Patel UK, Yao SS et al (2011) Standing and exercise Doppler echocardiography in obstructive hypertrophic cardiomyopathy: the range of gradients with upright activity. J Am Soc Echocardiogr 24: 75-82.
19. Agostoni P, Bianchi M, Moraschi A et al (2005) Work-rate affects cardiopulmonary exercise test results in heart failure. Eur J Heart Fail 7: 498-504.
20. Katritsis D, Camm AJ (1993) Chronotropic incompetence: a proposal for definition and diagnosis. Br Heart J 70: 400-402.
21. Wilkoff BL, Miller RE (1992) Exercise testing for chronotropic assessment. Cardiol Clin 10: 705-717.
22. Wasserman K, Hansen JE, Sue DY, Casaburi R, Whipp BJ (2005) Principles of exercise testing and interpretation, 4th edn. Lippincott Williams & Wilkins, Baltimore, pp 10-65.
23. Piepoli MF, Corrà U, Agostoni PG, Belardinelli R, Cohen-Solal A, Hambrecht R, Vanhees L (2006) Task Force of the Italian Working Group on Cardiac Rehabilitation Prevention. Working Group on Cardiac Rehabilitation and Exercise Physiology of the European Society of Cardiology. Statement on cardiopulmonary exercise testing in chronic heart failure due to left ventricular dysfunction: recommendation for performance and interpretation. I. Definition of cardiopulmonary exercise testing parameters for appropriate use in chronic heart failure. Eur J Cardiovasc Prev Rehabil 13: 150-164.
24. Simonetti OP, Kim RJ, Fieno DS et al (2001) An improved MR imaging technique for the visualization of myocardial infarction. Radiology 218: 215-223.
25. Adabag AS, Maron BJ, Appelbaum E et al (2008) Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy in relation to delayed enhancement on cardiovascular magnetic resonance. J Am Coll Cardiol 51: 1369-1374.
26. Metra M, Zacà V, Parati G, Heart Failure Study Group of the Italian Society of Cardiology et al (2011) Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure. J Cardiovasc Med (Hagerstown) 12: 76-84.
27. Magrì D, Volpe M (2009) Cardiopulmonary exercise testing in heart failure: from ugly duckling to swan. Intern Emerg Med 4: 263-264.
28. Bonow RO (1992) Determinants of exercise capacity in hypertrophic cardiomyopathy. J Am Coll Cardiol 19: 513-515.
29. Dumont CA, Monserrat L, Peteiro J et al (2007) Relation of left ventricular chamber stiffness at rest to exercise capacity in hypertrophic cardiomyopathy. Am J Cardiol 99: 1454-1457.
30. Sachdev V, Shizukuda Y, Brenneman CL et al (2005) Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy. Am Heart J 149: 730-736.
31. Rosenberg MA, Gottdiener JS, Heckbert SR, Mukamal KJ (2012) Echocardiographic diastolic parameters and risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J 33: 904-912.
32. Guazzi M, Myers J, Arena R (2005) Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure. J Am Coll Cardiol 46: 1883-1890.
33. Arena R, Owens DS, Arevalo J et al (2008) Ventilatory efficiency and resting hemodynamics in hypertrophic cardiomyopathy. Med Sci Sports Exerc 40: 799-805.
34. Guazzi M, Myers J, Peberdy MA, Bensimhon D, Chase P, Arena R (2010) Cardiopulmonary exercise testing variables reflect the degree of diastolic dysfunction in patients with heart failure-normal ejection fraction. J Cardiopulm Rehabil Prev 30: 165-172.
35. Rubinshtein R, Glockner JF, Ommen SR et al (2010) Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic cardiomyopathy. Circ Heart Fail 3: 51-58.
36. Motoyasu M, Kurita T, Onishi K et al (2008) Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging. Circ J 72: 378-383.
37. Oka K, Tsujino T, Nakao S et al (2008) Symptomatic ventricular tachyarrhythmia is associated with delayed gadolinium enhancement in cardiac magnetic resonance imaging and with elevated plasma brain natriuretic peptide level in hypertrophic cardiomyopathy. J Cardiol 52: 146-153.
38. Brubaker PH, Kitzman DW (2011) Chronotropic incompetence: causes, consequences, and management. Circulation 123: 1010-1020.
39. Colucci WS, Ribeiro JP, Rocco MB et al (1989) Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization. Circulation 80: 314-323.
40. Phan TT, Shivu GN, Abozguia K et al (2010) Impaired heart rate recovery and chronotropic incompetence in patients with heart failure with preserved ejection fraction. Circ Heart Fail 3: 29-34.
41. Gilligan DM, Chan WL, Sbarouni E, Nihoyannopoulos P, Oakley CM (1993) Autonomic function in hypertrophic cardiomyopathy. Br Heart J 69: 525-529.
42. Fananapazir L, Tracy CM, Leon MB et al (1989) Electrophysiologic abnormalities in patients with hypertrophic cardiomyopathy. A consecutive analysis in 155 patients. Circulation 80: 1259-1268.
43. Nistri S, Olivotto I, Maron MS et al (2010) Timing and significance of exercise-induced left ventricular outflow tract pressure gradients in hypertrophic cardiomyopathy. Am J Cardiol 106: 1301-1306.