Multifactorial relationship between 18F-fluoro-deoxy-glucose positron emission tomography signaling and biomechanical properties in unruptured aortic aneurysms

Circulation: Cardiovascular Imaging

Volumn 7, Issue 1, 2014, Pages 82-91

  Nchimi, Alain ^a   Cheramy Bien, Jean Paul ^b   Gasser, T Christian ^a   Namur, Gauthier ^c   Gomez, Pierre ^c   Seidel, Laurence ^d   Albert, Adelin ^d   Defraigne, Jean Olivier ^b   Labropoulos, Nicos ^e   Sakalihasan, Natzi ^b  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c Centre Hospitalier Chretien   (Belgium)

^d UNIVERSITY OF LIÈGE   (Belgium)

^e STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aneurysm; Aorta; Tomography

Indexed keywords

FLUORODEOXYGLUCOSE F 18; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ABDOMINAL AORTA ANEURYSM; AGED; ANGINA PECTORIS; AORTA ANEURYSM; ARTICLE; BIOLOGICAL ACTIVITY; BIOMECHANICS; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG UPTAKE; FAMILIAL DISEASE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIMULATION; STRENGTH; WALL STRESS; ANEURYSM; AORTA; AORTOGRAPHY; BIOLOGICAL MODEL; BLOOD FLOW; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; MECHANICAL STRESS; METHODOLOGY; MIDDLE AGED; MULTIMODAL IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PREDICTIVE VALUE; PROGNOSIS; RISK FACTOR; SCINTISCANNING; STATISTICAL MODEL; THORACIC AORTA ANEURYSM; TIME; TOMOGRAPHY; VERY ELDERLY; WHOLE BODY IMAGING;

ANEURYSM; AORTA; TOMOGRAPHY;

AGED; AGED, 80 AND OVER; AORTIC ANEURYSM, ABDOMINAL; AORTIC ANEURYSM, THORACIC; AORTOGRAPHY; BIOMECHANICAL PHENOMENA; COMPUTER SIMULATION; FEMALE; FINITE ELEMENT ANALYSIS; FLUORODEOXYGLUCOSE F18; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MODELS, CARDIOVASCULAR; MULTIMODAL IMAGING; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RADIOPHARMACEUTICALS; REGIONAL BLOOD FLOW; RISK FACTORS; STRESS, MECHANICAL; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; WHOLE BODY IMAGING;

EID: 84897020152     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.112.000415     Document Type: Article

References (38)

1. Gillum RF. Epidemiology of aortic aneurysm in the United States. J Clin Epidemiol. 1995;48: 1289-1298.
2. Bengtsson H, Sonesson B, Bergqvist D. Incidence and prevalence of abdominal aortic aneurysms, estimated by necropsy studies and population screening by ultrasound. Ann N Y Acad Sci. 1996;800: 1-24.
3. Dillavou ED, Muluk SC, Makaroun MS. Improving aneurysm-related outcomes: nationwide benefits of endovascular repair. J Vasc Surg. 2006;43: 446-451; discussion 451.
4. Greenhalgh RM, Brown LC, Powell JT, Thompson SG, Epstein D, Sculpher MJ; United Kingdom EVAR Trial Investigators. Endovascular versus open repair of abdominal aortic aneurysm. N Engl J Med. 2010;362: 1863-1871.
5. Brady AR, Thompson SG, Fowkes FG, Greenhalgh RM, Powell JT; UK Small Aneurysm Trial Participants. Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. Circulation. 2004;110: 16-21.
6. Elefteriades JA. Natural history of thoracic aortic aneurysms: indications for surgery, and surgical versus nonsurgical risks. Ann Thorac Surg. 2002;74: S1877-S1880; discussion S1892.
7. Brewster DC, Cronenwett JL, Hallett JW Jr, Johnston KW, Krupski WC, Matsumura JS; Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery. Guidelines for the treatment of abdominal aortic aneurysms. Report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery. J Vasc Surg. 2003;37: 1106-1117.
8. Darling RC, Messina CR, Brewster DC, Ottinger LW. Autopsy study of unoperated abdominal aortic aneurysms. The case for early resection. Circulation. 1977;56(3 Suppl): II161-II164.
9. Nicholls SC, Gardner JB, Meissner MH, Johansen HK. Rupture in small abdominal aortic aneurysms. J Vasc Surg. 1998;28: 884-888.
10. Brown LC, Powell JT. Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Ann Surg. 1999;230: 289-296; discussion 296.
11. Zienkiewicz OC, Taylor R.L., J.Z. Zhu. The Finite Elements Method. The Basis. 5th ed. Oxford, United Kingdom: Butterworth-Heinemann; 2000.
12. Raghavan ML, Hanaoka MM, Kratzberg JA, de Lourdes Higuchi M, da Silva ES. Biomechanical failure properties and microstructural content of ruptured and unruptured abdominal aortic aneurysms. J Biomech. 2011;44: 2501-2507.
13. Gasser TC, Görgülü G, Folkesson M, Swedenborg J. Failure properties of intraluminal thrombus in abdominal aortic aneurysm under static and pulsating mechanical loads. J Vasc Surg. 2008;48: 179-188.
14. Michel JB, Thaunat O, Houard X, Meilhac O, Caligiuri G, Nicoletti A. Topological determinants and consequences of adventitial responses to arterial wall injury. Arterioscler Thromb Vasc Biol. 2007;27: 1259-1268.
15. Fontaine V, Jacob MP, Houard X, Rossignol P, Plissonnier D, Angles-Cano E, Michel JB. Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms. Am J Pathol. 2002;161: 1701-1710.
16. Houard X, Rouzet F, Touat Z, Philippe M, Dominguez M, Fontaine V, Sarda-Mantel L, Meulemans A, Le Guludec D, Meilhac O, Michel JB. Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms. J Pathol. 2007;212: 20-28.
17. Defawe OD, Colige A, Lambert CA, Munaut C, Delvenne P, Lapière CM, Limet R, Nusgens BV, Sakalihasan N. TIMP-2 and PAI-1 mRNA levels are lower in aneurysmal as compared to athero-occlusive abdominal aortas. Cardiovasc Res. 2003;60: 205-213.
18. Sakalihasan N, Michel JB. Functional imaging of atherosclerosis to advance vascular biology. Eur J Vasc Endovasc Surg. 2009;37: 728-734.
19. Truijers M, Kurvers HA, Bredie SJ, Oyen WJ, Blankensteijn JD. In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall. J Endovasc Ther. 2008;15: 462-467.
20. Kotze CW, Menezes LJ, Endozo R, Groves AM, Ell PJ, Yusuf SW. Increased metabolic activity in abdominal aortic aneurysm detected by 18F- fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Eur J Vasc Endovasc Surg. 2009;38: 93-99.
21. Sakalihasan N, Hustinx R, Limet R. Contribution of PET scanning to the evaluation of abdominal aortic aneurysm. Semin Vasc Surg. 2004;17: 144-153.
22. Defawe OD, Hustinx R, Defraigne JO, Limet R, Sakalihasan N. Distribution of F-18 fluorodeoxyglucose (F-18 FDG) in abdominal aortic aneurysm: high accumulation in macrophages seen on PET imaging and immunohistology. Clin Nucl Med. 2005;30: 340-341.
23. Reeps C, Essler M, Pelisek J, Seidl S, Eckstein HH, Krause BJ. Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J Vasc Surg. 2008;48: 417-423; discussion 424.
24. Xu XY, Borghi A, Nchimi A, Leung J, Gomez P, Cheng Z, Defraigne JO, Sakalihasan N. High levels of 18F-FDG uptake in aortic aneurysm wall are associated with high wall stress. Eur J Vasc Endovasc Surg. 2010;39: 295-301.
25. http://ec.europa.eu/research/health/medical-research/cardiovascular- diseases/projects/fad-en.html. Accessed November 25, 2013.
26. A4clinics User Manual vers. 3.0 VG. A4clinics, Vascops GmbH, Graz, Austria.
27. Reeps C, Gee MW, Maier A, Pelisek J, Gurdan M, Wall W, Mariss J, Eckstein HH, Essler M. Glucose metabolism in the vessel wall correlates with mechanical instability and inflammatory changes in a patient with a growing aneurysm of the abdominal aorta. Circ Cardiovasc Imaging. 2009;2: 507-509.
28. Maier A, Gee MW, Reeps C, Eckstein HH, Wall WA. Impact of calcifications on patient-specific wall stress analysis of abdominal aortic aneurysms. Biomech Model Mechanobiol. 2010;9: 511-521.
29. Wang DH, Makaroun MS, Webster MW, Vorp DA. Effect of intraluminal thrombus on wall stress in patient-specific models of abdominal aortic aneurysm. J Vasc Surg. 2002;36: 598-604.
30. Kazi M, Thyberg J, Religa P, Roy J, Eriksson P, Hedin U, Swedenborg J. Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall. J Vasc Surg. 2003;38: 1283-1292.
31. Dobrin PB. Pathophysiology and pathogenesis of aortic aneurysms. Current concepts. Surg Clin North Am. 1989;69: 687-703.
32. Fillinger MF, Marra SP, Raghavan ML, Kennedy FE. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J Vasc Surg. 2003;37: 724-732.
33. Sakalihasan N, Limet R, Defawe OD. Abdominal aortic aneurysm. Lancet. 2005;365: 1577-1589.
34. Nordon IM, Hinchliffe RJ, Loftus IM, Thompson MM. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol. 2011;8: 92-102.
35. Verloes A, Sakalihasan N, Koulischer L, Limet R. Aneurysms of the abdominal aorta: familial and genetic aspects in three hundred thirteen pedigrees. J Vasc Surg. 1995;21: 646-655.
36. Georgakarakos E, Ioannou CV, Papaharilaou Y, Kostas T, Tsetis D, Katsamouris AN. Peak wall stress does not necessarily predict the location of rupture in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2010;39: 302-304.
37. Gasser TC, Auer M, Labruto F, Swedenborg J, Roy J. Biomechanical rupture risk assessment of abdominal aortic aneurysms: model complexity versus predictability of finite element simulations. Eur J Vasc Endovasc Surg. 2010;40: 176-185.
38. Cecchi E, Giglioli C, Valente S, Lazzeri C, Gensini GF, Abbate R, Mannini L. Role of hemodynamic shear stress in cardiovascular disease. Atherosclerosis. 2011;214: 249-256.