To the editor: The FIP1L1-PDGFRA fusion gene and the KIT D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia

Blood

Volumn 123, Issue 4, 2014, Pages 595-597

  Schmitt Graeff, Annette Hildegard ^a   Erben, Philipp ^b   Schwaab, Juliane ^b   Vollmer Kary, Beate ^a   Metzgeroth, Georgia ^b   Sotlar, Karl ^c   Horny, Hans Peter ^c   Kreipe, Hans H ^d   Fisch, Paul ^a   Reiter, Andreas ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; EDETIC ACID; GENOMIC DNA; INTERLEUKIN 2 RECEPTOR ALPHA; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; TRYPTASE; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; FIP1L1 PROTEIN, HUMAN; ONCOPROTEIN;

BONE MARROW BIOPSY; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHILIA; FIP1L1 PDGFRA FUSION GENE; FUSION GENE; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; LETTER; LYMPHATIC LEUKEMIA; MAST CELL; MICRODISSECTION; MUTATIONAL ANALYSIS; MYELOID LEUKEMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SYSTEMIC MASTOCYTOSIS; SYSTEMIC MASTOCYTOSIS WITH ASSOCIATED HEMATOLOGICAL NON MAST CELL DISORDER; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; BIOPSY; BONE MARROW CELL; CYTOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GRANULOCYTIC SARCOMA; HYPEREOSINOPHILIC SYNDROME; METABOLISM; MUTATION;

ANTIGENS, CD2; BIOPSY; BONE MARROW CELLS; EOSINOPHILIA; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; HYPEREOSINOPHILIC SYNDROME; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKEMIA, MYELOID, ACUTE; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; MUTATION; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SARCOMA, MYELOID; TRYPTASES;

EID: 84897018285     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-10-530642     Document Type: Letter

References (8)

1. Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissue, 4th ed. Lyon, France: IARC Press; 2008.
2. Pardanani A, Brockman SR, Paternoster SF, et al. FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. Blood. 2004;104(10):3038-3045. (Pubitemid 39507117)
3. Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348(13):1201-1214. (Pubitemid 36359296)
4. Metzgeroth G, Schwaab J, Gosenca D, et al. Long-term follow-up of treatment with imatinib in eosinophilia-associated myeloid/lymphoid neoplasms with PDGFR rearrangements in blast phase. Leukemia. 2013;27(11): 2254-2256.
5. Pardanani A, Lim KH, Lasho TL, et al. Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies. Blood. 2009;114(18):3769-3772.
6. Sotlar K, Colak S, Bache A, et al. Variable presence of KITD816V in clonal haematological non-mast cell lineage diseases associated with systemic mastocytosis (SM-AHNMD). J Pathol. 2010;220(5):586-595.
7. Schwaab J, Schnittger S, Sotlar K, et al. Comprehensive mutational profiling in advanced systemic mastocytosis. Blood. 2013;122(14):2460-2466.
8. Yamada Y, Sanchez-Aguilera A, Brandt EB, et al. FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood. 2008;112(6): 2500-2507.