메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages

Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: Correlations with the course of disease

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CD34 ANTIGEN;

EID: 84897015589     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084496     Document Type: Article
Times cited : (40)

References (55)
  • 1
    • 79952092993 scopus 로고    scopus 로고
    • Leukemia stem cells and microenvironment: Biology and therapeutic targeting
    • Konopleva MY, Jordan CT (2011) Leukemia stem cells and microenvironment: biology and therapeutic targeting. J Clin Oncol 29: 591-599.
    • (2011) J Clin Oncol , vol.29 , pp. 591-599
    • Konopleva, M.Y.1    Jordan, C.T.2
  • 2
    • 69849104865 scopus 로고    scopus 로고
    • The leukemic stem cell niche: Current concepts and therapeutic opportunities
    • Lane SW, Scadden DT, Gilliland DG (2009) The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 114: 1150-1157.
    • (2009) Blood , vol.114 , pp. 1150-1157
    • Lane, S.W.1    Scadden, D.T.2    Gilliland, D.G.3
  • 3
    • 57849108116 scopus 로고    scopus 로고
    • Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells
    • Colmone A, Amorim M, Pontier AL, Wang S, Jablonski E, et al. (2008) Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science 322: 1861-1865.
    • (2008) Science , vol.322 , pp. 1861-1865
    • Colmone, A.1    Amorim, M.2    Pontier, A.L.3    Wang, S.4    Jablonski, E.5
  • 5
    • 84989485234 scopus 로고
    • The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells
    • Friedenstein AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3: 393-403.
    • (1970) Cell Tissue Kinet , vol.3 , pp. 393-403
    • Friedenstein, A.J.1    Chailakhjan, R.K.2    Lalykina, K.S.3
  • 6
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI (1991) Mesenchymal stem cells. J Orthop Res 9: 641-650.
    • (1991) J Orthop Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 7
    • 0026630954 scopus 로고
    • Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia
    • Manabe A, Coustan-Smith E, Behm FG, Raimondi SC, Campana D (1992) Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia. Blood 79: 2370-2377.
    • (1992) Blood , vol.79 , pp. 2370-2377
    • Manabe, A.1    Coustan-Smith, E.2    Behm, F.G.3    Raimondi, S.C.4    Campana, D.5
  • 8
    • 0034284302 scopus 로고    scopus 로고
    • Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy
    • Mudry RE, Fortney JE, York T, Hall BM, Gibson LF (2000) Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. Blood 96: 1926-1932. (Pubitemid 30661079)
    • (2000) Blood , vol.96 , Issue.5 , pp. 1926-1932
    • Mudry, M.E.1    Fortney, J.E.2    York, T.3    Hall, B.M.4    Gibson, L.F.5
  • 9
    • 34447131774 scopus 로고    scopus 로고
    • Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia
    • DOI 10.3324/haematol.10621
    • Juarez J, Baraz R, Gaundar S, Bradstock K, Bendall L (2007) Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia. Haematologica 92: 450-459. (Pubitemid 350144290)
    • (2007) Haematologica , vol.92 , Issue.4 , pp. 450-459
    • Juarez, J.1    Baraz, R.2    Gaundar, S.3    Bradstock, K.4    Bendall, L.5
  • 11
    • 57349190606 scopus 로고    scopus 로고
    • Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: Role of TGFbeta/BMP-6 and TIEG1 in chemotherapy escape
    • Dosen-Dahl G, Munthe E, Nygren MK, Stubberud H, Hystad ME, et al. (2008) Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: role of TGFbeta/BMP-6 and TIEG1 in chemotherapy escape. Int J Cancer 123: 2759-2766.
    • (2008) Int J Cancer , vol.123 , pp. 2759-2766
    • Dosen-Dahl, G.1    Munthe, E.2    Nygren, M.K.3    Stubberud, H.4    Hystad, M.E.5
  • 12
    • 0033380772 scopus 로고    scopus 로고
    • Lineage-restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines
    • Detmer K, Steele TA, Shoop MA, Dannawi H (1999) Lineage-restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines. Blood Cells Mol Dis 25: 310-323. (Pubitemid 30103951)
    • (1999) Blood Cells, Molecules, and Diseases , vol.25 , Issue.5-6 , pp. 310-323
    • Detmer, K.1    Steele, T.A.2    Shoop, M.A.3    Dannawi, H.4
  • 14
    • 0037085765 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy
    • DOI 10.1182/blood.V99.6.2179
    • Dias S, Choy M, Alitalo K, Rafii S (2002) Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 99: 2179-2184. (Pubitemid 34525504)
    • (2002) Blood , vol.99 , Issue.6 , pp. 2179-2184
    • Dias, S.1    Choy, M.2    Alitalo, K.3    Rafii, S.4
  • 16
    • 84873546072 scopus 로고    scopus 로고
    • A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-alpha4 expression
    • Khurana S, Buckley S, Schouteden S, Ekker S, Petryk A, et al. (2013) A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-alpha4 expression. Blood 121: 781-790.
    • (2013) Blood , vol.121 , pp. 781-790
    • Khurana, S.1    Buckley, S.2    Schouteden, S.3    Ekker, S.4    Petryk, A.5
  • 17
    • 79957851861 scopus 로고    scopus 로고
    • Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency
    • Vicente Lopez MA, Vazquez Garcia MN, Entrena A, Olmedillas Lopez S, Garcia-Arranz M, et al. (2011) Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency. Stem Cells Dev 20: 1011-1019.
    • (2011) Stem Cells Dev , vol.20 , pp. 1011-1019
    • Vicente Lopez, M.A.1    Vazquez Garcia, M.N.2    Entrena, A.3    Olmedillas Lopez, S.4    Garcia-Arranz, M.5
  • 18
    • 84865858355 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 - A fascinating regulator of cancer cell behavior
    • Kallioniemi A (2012) Bone morphogenetic protein 4-a fascinating regulator of cancer cell behavior. Cancer Genet 205: 267-277.
    • (2012) Cancer Genet , vol.205 , pp. 267-277
    • Kallioniemi, A.1
  • 19
    • 84892854518 scopus 로고    scopus 로고
    • Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and BMPRIb overexpression
    • 10.1182/blood-2013-05-501460
    • Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, et al. (2013) Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and BMPRIb overexpression. Blood 10.1182/blood-2013-05-501460.
    • (2013) Blood
    • Laperrousaz, B.1    Jeanpierre, S.2    Sagorny, K.3    Voeltzel, T.4    Ramas, S.5
  • 20
    • 54049136911 scopus 로고    scopus 로고
    • BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway
    • Fong YC, Li TM, Wu CM, Hsu SF, Kao ST, et al. (2008) BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway. J Cell Physiol 217: 846-855.
    • (2008) J Cell Physiol , vol.217 , pp. 846-855
    • Fong, Y.C.1    Li, T.M.2    Wu, C.M.3    Hsu, S.F.4    Kao, S.T.5
  • 22
    • 79961006281 scopus 로고    scopus 로고
    • Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
    • McLean K, Gong Y, Choi Y, Deng N, Yang K, et al. (2011) Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. J Clin Invest 121: 3206-3219.
    • (2011) J Clin Invest , vol.121 , pp. 3206-3219
    • McLean, K.1    Gong, Y.2    Choi, Y.3    Deng, N.4    Yang, K.5
  • 23
    • 0034961533 scopus 로고    scopus 로고
    • Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute lymphoblastic leukemia. Final results of the prospective randomized PETHEMA ALL-89 TRIAL
    • Ortega JJ, Ribera JM, Oriol A, Bastida P, Gonzalez ME, et al. (2001) Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute lymphoblastic leukemia. Final results of the prospective randomized PETHEMA ALL-89 TRIAL. Haematologica 86: 586-595.
    • (2001) Haematologica , vol.86 , pp. 586-595
    • Ortega, J.J.1    Ribera, J.M.2    Oriol, A.3    Bastida, P.4    Gonzalez, M.E.5
  • 24
    • 84876724554 scopus 로고    scopus 로고
    • Detection of occult cerebrospinal fluid involvement during maintenance therapy identifies a group of children with acute lymphoblastic leukemia at high risk for relapse
    • Martinez-Laperche C, Gomez-Garcia AM, Lassaletta A, Moscardo C, Vivanco JL, et al. (2013) Detection of occult cerebrospinal fluid involvement during maintenance therapy identifies a group of children with acute lymphoblastic leukemia at high risk for relapse. Am J Hematol 88: 359-364.
    • (2013) Am J Hematol , vol.88 , pp. 359-364
    • Martinez-Laperche, C.1    Gomez-Garcia, A.M.2    Lassaletta, A.3    Moscardo, C.4    Vivanco, J.L.5
  • 26
    • 53349108947 scopus 로고    scopus 로고
    • Regulation of proliferation and differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchus mykiss)
    • Bouraoui L, Gutierrez J, Navarro I (2008) Regulation of proliferation and differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchus mykiss). J Endocrinol 198: 459-469.
    • (2008) J Endocrinol , vol.198 , pp. 459-469
    • Bouraoui, L.1    Gutierrez, J.2    Navarro, I.3
  • 27
    • 27744457043 scopus 로고    scopus 로고
    • Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro
    • DOI 10.1016/j.bbrc.2005.09.198, PII S0006291X05022084
    • Schindeler A, Little DG (2005) Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochem Biophys Res Commun 338: 710-716. (Pubitemid 41597701)
    • (2005) Biochemical and Biophysical Research Communications , vol.338 , Issue.2 , pp. 710-716
    • Schindeler, A.1    Little, D.G.2
  • 28
    • 33846483151 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: Impact on in vivo tumor growth
    • DOI 10.1038/sj.leu.2404489, PII 2404489
    • Ramasamy R, Lam EW, Soeiro I, Tisato V, Bonnet D, et al. (2007) Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 21: 304-310. (Pubitemid 46158124)
    • (2007) Leukemia , vol.21 , Issue.2 , pp. 304-310
    • Ramasamy, R.1    Lam, E.W.-F.2    Soeiro, I.3    Tisato, V.4    Bonnet, D.5    Dazzi, F.6
  • 29
    • 4544286802 scopus 로고    scopus 로고
    • Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction
    • DOI 10.1515/BC.2004.086
    • Sebald W, Nickel J, Zhang JL, Mueller TD (2004) Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction. Biol Chem 385: 697-710. (Pubitemid 39255628)
    • (2004) Biological Chemistry , vol.385 , Issue.8 , pp. 697-710
    • Sebald, W.1    Nickel, J.2    Zhang, J.-L.3    Mueller, T.4
  • 30
    • 84858332746 scopus 로고    scopus 로고
    • The signaling and functions of heterodimeric bone morphogenetic proteins
    • Guo J, Wu G (2012) The signaling and functions of heterodimeric bone morphogenetic proteins. Cytokine Growth Factor Rev 23: 61-67.
    • (2012) Cytokine Growth Factor Rev , vol.23 , pp. 61-67
    • Guo, J.1    Wu, G.2
  • 31
    • 70649109834 scopus 로고    scopus 로고
    • Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism
    • Schulz TJ, Tseng YH (2009) Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev 20: 523-531.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 523-531
    • Schulz, T.J.1    Tseng, Y.H.2
  • 32
    • 84878960278 scopus 로고    scopus 로고
    • The role of focal adhesion kinase in BMP4 induction of mesenchymal stem cell adipogenesis
    • Lee JS, Ha L, Kwon IK, Lim JY (2013) The role of focal adhesion kinase in BMP4 induction of mesenchymal stem cell adipogenesis. Biochem Biophys Res Commun 435: 696-701.
    • (2013) Biochem Biophys Res Commun , vol.435 , pp. 696-701
    • Lee, J.S.1    Ha, L.2    Kwon, I.K.3    Lim, J.Y.4
  • 34
    • 77954928083 scopus 로고    scopus 로고
    • Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes
    • Klaus M, Stavroulaki E, Kastrinaki MC, Fragioudaki P, Giannikou K, et al. (2010) Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes. Stem Cells Dev 19: 1043-1054.
    • (2010) Stem Cells Dev , vol.19 , pp. 1043-1054
    • Klaus, M.1    Stavroulaki, E.2    Kastrinaki, M.C.3    Fragioudaki, P.4    Giannikou, K.5
  • 35
    • 33645392228 scopus 로고    scopus 로고
    • Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: Correlation with bone marrow microenvironment
    • Campioni D, Moretti S, Ferrari L, Punturieri M, Castoldi GL, et al. (2006) Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment. Haematologica 91: 364-368.
    • (2006) Haematologica , vol.91 , pp. 364-368
    • Campioni, D.1    Moretti, S.2    Ferrari, L.3    Punturieri, M.4    Castoldi, G.L.5
  • 36
    • 64849104318 scopus 로고    scopus 로고
    • Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q-syndrome
    • Lopez-Villar O, Garcia JL, Sanchez-Guijo FM, Robledo C, Villaron EM, et al. (2009) Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q-syndrome. Leukemia 23: 664-672.
    • (2009) Leukemia , vol.23 , pp. 664-672
    • Lopez-Villar, O.1    Garcia, J.L.2    Sanchez-Guijo, F.M.3    Robledo, C.4    Villaron, E.M.5
  • 37
    • 34548512229 scopus 로고    scopus 로고
    • Phenotypic and functional comparison of mesenchymal stem cells derived from the bone marrow of normal adults and patients with hematologic malignant diseases
    • DOI 10.1089/scd.2007.0008
    • Zhao ZG, Liang Y, Li K, Li WM, Li QB, et al. (2007) Phenotypic and functional comparison of mesenchymal stem cells derived from the bone marrow of normal adults and patients with hematologic malignant diseases. Stem Cells Dev 16: 637-648. (Pubitemid 47378736)
    • (2007) Stem Cells and Development , vol.16 , Issue.4 , pp. 637-648
    • Zhao, Z.-G.1    Liang, Y.2    Li, K.3    Li, W.-M.4    Li, Q.-B.5    Chen, Z.-C.6    Zou, P.7
  • 38
    • 2542479890 scopus 로고    scopus 로고
    • Signal transduction and biological functions of bone morphogenetic proteins
    • d1-504
    • Chen D, Zhao M, Harris SE, Mi Z (2004) Signal transduction and biological functions of bone morphogenetic proteins. Front Biosci 9: 349-358. (Pubitemid 38925465)
    • (2004) Frontiers in Bioscience , vol.9 , pp. 349-358
    • Chen, D.1    Zhao, M.2    Harris, S.E.3    Mi, Z.4
  • 39
    • 0036060972 scopus 로고    scopus 로고
    • Bone morphogenetic proteins act synergistically with haematopoietic cytokines in the differentiation of haematopoietic progenitors
    • Detmer K, Walker AN (2002) Bone morphogenetic proteins act synergistically with haematopoietic cytokines in the differentiation of haematopoietic progenitors. Cytokine 17: 36-42.
    • (2002) Cytokine , vol.17 , pp. 36-42
    • Detmer, K.1    Walker, A.N.2
  • 40
    • 12844284481 scopus 로고    scopus 로고
    • Leukemic transformation in myelofibrosis with myeloid metaplasia: A single-institution experience with 91 cases
    • DOI 10.1182/blood-2004-07-2864
    • Mesa RA, Li CY, Ketterling RP, Schroeder GS, Knudson RA, et al. (2005) Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases. Blood 105: 973-977. (Pubitemid 40170863)
    • (2005) Blood , vol.105 , Issue.3 , pp. 973-977
    • Mesa, R.A.1    Li, C.-Y.2    Ketterling, R.P.3    Schroeder, G.S.4    Knudson, R.A.5    Tefferi, A.6
  • 41
    • 67649271549 scopus 로고    scopus 로고
    • A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells
    • Kang Q, Song WX, Luo Q, Tang N, Luo J, et al. (2009) A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev 18: 545-559.
    • (2009) Stem Cells Dev , vol.18 , pp. 545-559
    • Kang, Q.1    Song, W.X.2    Luo, Q.3    Tang, N.4    Luo, J.5
  • 42
    • 23244432429 scopus 로고    scopus 로고
    • BMP signaling and stem cell regulation
    • DOI 10.1016/j.ydbio.2005.05.009, PII S0012160605003015
    • Zhang J, Li L (2005) BMP signaling and stem cell regulation. Dev Biol 284: 1-11. (Pubitemid 41096719)
    • (2005) Developmental Biology , vol.284 , Issue.1 , pp. 1-11
    • Zhang, J.1    Li, L.2
  • 43
    • 70450217019 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium
    • Solmesky LJ, Abekasis M, Bulvik S, Weil M (2009) Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium. Stem Cells Dev 18: 1283-1292.
    • (2009) Stem Cells Dev , vol.18 , pp. 1283-1292
    • Solmesky, L.J.1    Abekasis, M.2    Bulvik, S.3    Weil, M.4
  • 46
    • 34247635666 scopus 로고    scopus 로고
    • Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression
    • DOI 10.1038/sj.leu.2404657, PII 2404657
    • Sengupta A, Banerjee D, Chandra S, Banerji SK, Ghosh R, et al. (2007) Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression. Leukemia 21: 949-955. (Pubitemid 46672071)
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 949-955
    • Sengupta, A.1    Banerjee, D.2    Chandra, S.3    Banerji, S.K.4    Ghosh, R.5    Roy, R.6    Banerjee, S.7
  • 47
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, et al. (2009) Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458: 776-779.
    • (2009) Nature , vol.458 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3    Fereshteh, M.4    Abrahamsson, A.5
  • 48
    • 0033526067 scopus 로고    scopus 로고
    • Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells
    • Bhatia M, Bonnet D, Wu D, Murdoch B, Wrana J, et al. (1999) Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells JEM 189: 1139-1148.
    • (1999) JEM , vol.189 , pp. 1139-1148
    • Bhatia, M.1    Bonnet, D.2    Wu, D.3    Murdoch, B.4    Wrana, J.5
  • 49
    • 36749049256 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines
    • DOI 10.1016/j.cyto.2007.09.004, PII S1043466607003912
    • Grassinger J, Simon M, Mueller G, Drewel D, Andreesen R, et al. (2007) Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines. Cytokine 40: 165-171. (Pubitemid 350213428)
    • (2007) Cytokine , vol.40 , Issue.3 , pp. 165-171
    • Grassinger, J.1    Simon, M.2    Mueller, G.3    Drewel, D.4    Andreesen, R.5    Hennemann, B.6
  • 51
    • 74849135750 scopus 로고    scopus 로고
    • Interplay between BMP4 and IL-7 in human intrathymic precursor cells
    • Varas A, Sacedon R, Hidalgo L, Martinez VG, Valencia J, et al. (2009) Interplay between BMP4 and IL-7 in human intrathymic precursor cells. Cell Cycle 8: 4119-4126.
    • (2009) Cell Cycle , vol.8 , pp. 4119-4126
    • Varas, A.1    Sacedon, R.2    Hidalgo, L.3    Martinez, V.G.4    Valencia, J.5
  • 52
    • 33745631250 scopus 로고    scopus 로고
    • T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization
    • Rifas L (2006) T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization. J Cell Biochem 98: 706-714.
    • (2006) J Cell Biochem , vol.98 , pp. 706-714
    • Rifas, L.1
  • 53
    • 39649091183 scopus 로고    scopus 로고
    • Inappropriate Notch activity and limited mesenchymal stem cell plasticity in the bone marrow of patients with myelodysplasia syndromes
    • Varga G, Kiss J, Varkonyi J, Vas V, Farkas P, et al. (2007) Inappropriate Notch activity and limited mesenchymal stem cell plasticity in the bone marrow of patients with myelodysplastic syndromes. Pathol Oncol Res 13: 311-319. (Pubitemid 351287312)
    • (2007) Pathology and Oncology Research , vol.13 , Issue.4 , pp. 311-319
    • Varga, G.1    Kiss, J.2    Varkonyi, J.3    Vas, V.4    Farkas, P.5    Paloczi, K.6    Uher, F.7
  • 55
    • 67650504733 scopus 로고    scopus 로고
    • Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
    • Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, et al. (2009) Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 460: 259-263.
    • (2009) Nature , vol.460 , pp. 259-263
    • Naveiras, O.1    Nardi, V.2    Wenzel, P.L.3    Hauschka, P.V.4    Fahey, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.