Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 12, 2014, Pages 4584-4589

  Giustiniani, Julien ^a   Chambraud, Béatrice ^a   Sardin, Elodie ^a   Dounane, Omar ^a   Guillemeau, Kevin ^a   Nakatani, Hiroko ^a   Paquet, Dominik ^b,d   Kamah, Amina ^c   Landrieu, Isabelle ^c   Lippens, Guy ^c   Baulieu, Etienne Emile ^a   Tawk, Marcel ^a  

^a INSERM   (France)

^b UNIVERSITY OF MUNICH   (Germany)

^c CNRS   (France)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

FKBP; Tau assembly; Tau P301L dementia

Indexed keywords

FK 506 BINDING PROTEIN; FKBP52 PROTEIN; IMMUNOPHILIN; TAU P301L PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONFORMATIONAL TRANSITION; EMBRYO; ESCAPE BEHAVIOR; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOTONEURON; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FILAMENTOUS ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TAUOPATHY; WESTERN BLOTTING; ZEBRA FISH;

FKBP; TAU ASSEMBLY; TAU-P301L DEMENTIA;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOPOLYMERS; CELL DEATH; CELL LINE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MODELS, BIOLOGICAL; MOTOR NEURONS; PHOSPHORYLATION; STEREOTYPED BEHAVIOR; TACROLIMUS BINDING PROTEINS; TAU PROTEINS; TAUOPATHIES; ZEBRAFISH;

EID: 84897005564     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402645111     Document Type: Article

References (30)

1. Avila J, Lucas JJ, Perez M, Hernandez F (2004) Role of tau protein in both physiological and pathological conditions. Physiol Rev 84(2):361-384. (Pubitemid 38365487)
2. Morris M, Maeda S, Vossel K, Mucke L (2011) The many faces of tau. Neuron 70(3):410-426.
3. Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (1988) Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau. Proc Natl Acad Sci USA 85(11):4051-4055.
4. Sergeant N, et al. (2008) Biochemistry of Tau in Alzheimer's disease and related neurological disorders. Expert Rev Proteomics 5(2):207-224. (Pubitemid 351670926)
5. Mandelkow EM, Mandelkow E (2012) Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med 2(7):a006247.
6. Barghorn S, Mandelkow E (2002) Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments. Biochemistry 41(50):14885-14896. (Pubitemid 35470667)
7. Sahara N, Maeda S, Takashima A (2008) Tau oligomerization: A role for tau aggregation intermediates linked to neurodegeneration. Curr Alzheimer Res 5(6):591-598.
8. Xu S, Brunden KR, Trojanowski JQ, Lee VM (2010) Characterization of tau fibrillization in vitro. Alzheimers Dement 6(2):110-117.
9. Goedert M, Crowther RA, Spillantini MG (1998) Tau mutations cause frontotemporal dementias. Neuron 21(5):955-958. (Pubitemid 29018067)
10. Paquet D, et al. (2009) A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest 119(5):1382-1395.
11. Chambraud B, et al. (1993) Overexpression of p59-HBI (FKBP59), full length and domains, and characterization of PPlase activity. Biochem Biophys Res Commun 196(1):160-166. (Pubitemid 23309488)
12. Göthel SF, Marahiel MA (1999) Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol Life Sci 55(3):423-436. (Pubitemid 29178881)
13. Schiene-Fischer C, Aumüller T, Fischer G (2013) Peptide bond cis/trans isomerases: A biocatalysis perspective of conformational dynamics in proteins. Top Curr Chem 328:35-67.
14. Radanyi C, Chambraud B, Baulieu EE (1994) The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. Proc Natl Acad Sci USA 91(23):11197-11201. (Pubitemid 24349653)
15. Bose S, Weikl T, Bügl H, Buchner J (1996) Chaperone function of Hsp90-associated proteins. Science 274(5293):1715-1717. (Pubitemid 26414904)
16. Chambraud B, Belabes H, Fontaine-Lenoir V, Fellous A, Baulieu EE (2007) The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. FASEB J 21(11):2787-2797. (Pubitemid 47372746)
17. Chambraud B, et al. (2010) A role for FKBP52 in Tau protein function. Proc Natl Acad Sci USA 107(6):2658-2663.
18. Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 284(19):12845-12852.
19. Spillantini MG, Crowther RA, Kamphorst W, Heutink P, van Swieten JC (1998) Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau. Am J Pathol 153(5):1359-1363. (Pubitemid 28509890)
20. Plucińska G, et al. (2012) In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. J Neurosci 32(46):16203-16212.
21. Melançon E, Liu DW, Westerfield M, Eisen JS (1997) Pathfinding by identified zebrafish motoneurons in the absence of muscle pioneers. J Neurosci 17(20):7796-7804. (Pubitemid 27426217)
22. Gerard M, et al. (2010) Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology. J Neurosci 30(7):2454-2463.
23. Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP (1999) The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399(6738):784-788. (Pubitemid 29293174)
24. Giustiniani J, et al. (2012) Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17. J Alzheimers Dis 29(2):471-483.
25. Santa-Maria I, et al. (2012) Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes. J Biol Chem 287(24):20522-20533.
26. Johnston JA, Ward CL, Kopito RR (1998) Aggresomes: A cellular response to misfolded proteins. J Cell Biol 143(7):1883-1898. (Pubitemid 29022611)
27. Goedert M, Jakes R (1990) Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 9(13):4225-4230. (Pubitemid 120025977)
28. Goedert M (1993) Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci 16(11):460-465.
29. Tawk M, et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446(7137):797-800. (Pubitemid 46582037)
30. Tawk M, et al. (2011) Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis. J Neurosci 31(10):3729-3742.