Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes

Journal of Diabetes Research

Volumn 2014, Issue , 2014, Pages

  Sun, Ai Li ^a   Ni, Yi Hong ^a   Li, Xiao Bo ^a   Zhuang, Xiang Hua ^a   Liu, Yuan Tao ^a   Liu, Xin Hua ^b   Chen, Shi Hong ^a  

^a THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

^b Qingdao Haici Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYANOCOBALAMIN; METHYLMALONIC ACID; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; CREATININE URINE LEVEL; CYANOCOBALAMIN DEFICIENCY; DIABETIC NEUROPATHY; ELECTROMYOGRAM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; METHYLMALONIC ACIDURIA; MIDDLE AGED; MOTOR NERVE CONDUCTION; NERVE CONDUCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PERONEUS NERVE; PRIORITY JOURNAL; ULNAR NERVE; VITAMIN BLOOD LEVEL; ASIAN; BLOOD; CHINA; METABOLISM; MOTONEURON; PATHOPHYSIOLOGY; POLYNEUROPATHY; PROSPECTIVE STUDY; SENSORY RECEPTOR; SEVERITY OF ILLNESS INDEX; URINE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; CHINA; DIABETES MELLITUS, TYPE 2; DIABETIC NEUROPATHIES; FEMALE; HUMANS; MALE; METHYLMALONIC ACID; MIDDLE AGED; MOTOR NEURONS; NEURAL CONDUCTION; POLYNEUROPATHIES; PROSPECTIVE STUDIES; SENSORY RECEPTOR CELLS; SEVERITY OF ILLNESS INDEX; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84896986764     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2014/921616     Document Type: Article

References (24)

1. Davies M., Brophy S., Williams R., Taylor A., The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 2006 29 7 1518 1522 2-s2.0-33746441608 10.2337/dc05-2228 (Pubitemid 44127574)
2. Benbow S. J., Wallymahmed M. E., Macfarlane I. A., Diabetic peripheral neuropathy and quality of life. QJM 1998 91 11 733 737 2-s2.0-0031768685 (Pubitemid 28508618)
3. Tesfaye S., Advances in the management of diabetic peripheral neuropathy. Current Opinion in Supportive and Palliative Care 2009 3 2 136 143 2-s2.0-67651235626 10.1097/SPC.0b013e32832b7df5
4. England J. D., Gronseth G. S., Franklin G., Carter G. T., Kinsella L. J., Cohen J. A., Asbury A. K., Szigeti K., Lupski J. R., Latov N., Lewis R. A., Low P. A., Fisher M. A., Herrmann D. N., Howard J. F., Lauria G., Miller R. G., Polydefkis M., Sumner A. J., Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy,and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology 2009 72 2 177 184 2-s2.0-60549087147 10.1212/01.wnl.0000336345.70511.0f
5. Lindenbaum J., Savage D. G., Stabler S. P., Allen R. H., Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. American Journal of Hematology 1990 34 2 99 107 2-s2.0-0025335524 10.1002/ajh.2830340205 (Pubitemid 20180101)
6. Matchar D. B., McCrory D. C., Millington D. S., Feussner J. R., Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. American Journal of the Medical Sciences 1994 308 5 276 283 2-s2.0-0028020033 (Pubitemid 24345612)
7. Behrens M. I., Koh J., Canzoniero L. M. T., Sensi S. L., Csernansky C. A., Choi D. W., 3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons. NeuroReport 1995 6 3 545 548 2-s2.0-0028894042
8. Zeevalk G. D., Derr-Yellin E., Nicklas W. J., Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. Journal of Pharmacology and Experimental Therapeutics 1995 275 3 1124 1130 2-s2.0-0029550090 (Pubitemid 26129913)
9. Cox E. V., White A. M., Methylmalonic acid excretion: an index of vitamin-B12 deficiency. The Lancet 1962 280 7261 853 856 2-s2.0-0000131449
10. Matchar D. B., Feussner J. R., Millington D. S., Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. Annals of Internal Medicine 1987 106 5 707 710 2-s2.0-0023262020 (Pubitemid 17067990)
11. Lu B., Hu J., Wen J., Determination of peripheral neuropathy prevalence and associated factors in Chinese subjects with diabetes and pre-Diabetes- ShangHai Diabetic neuRopathy epidemiology and molecular genetics study (SH-DREAMS). PLoS One 2013 8 4 e61053
12. Knuiman M. W., Welborn T. A., McCann V. J., Prevalence of diabetic complications in relation to risk factors. Diabetes 1986 35 12 1332 1339 2-s2.0-0022976438 (Pubitemid 17199165)
13. Young M. J., Boulton A. J. M., Macleod A. F., Williams D. R. R., Sonksen P. H., A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993 36 2 150 154 2-s2.0-0027459676 10.1007/BF00400697 (Pubitemid 23034314)
14. Clarke R., Refsum H., Birks J., Evans J. G., Johnston C., Sherliker P., Ueland P. M., Schneede J., McPartlin J., Nexo E., Scott J. M., Screening for vitamin B-12 and folate deficiency in older persons. American Journal of Clinical Nutrition 2003 77 5 1241 1247 2-s2.0-0038474037 (Pubitemid 44858442)
15. Bjørke Monsen A. L., Ueland P. M., Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence. American Journal of Clinical Nutrition 2003 78 1 7 21 2-s2.0-0038168733 (Pubitemid 39655243)
16. Lindgren A., Kilander A., Bagge E., Nexø E., Holotranscobalamin-a sensitive marker of cobalamin malabsorption. European Journal of Clinical Investigation 1999 29 4 321 329 2-s2.0-0032925193 10.1046/j.1365-2362.1999. 00446.x (Pubitemid 29188825)
17. Nexo E., Hoffmann-Lücke E., Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility. American Journal of Clinical Nutrition 2011 94 1 359S 365S 2-s2.0-79959460458 10.3945/ajcn.111. 013458
18. Flatley J. E., Garner C. M., Al-Turki M., Manning N. J., Olpin S. E., Barker M. E., Powers H. J., Determinants of urinary methylmalonic acid concentration in an elderly population in the United Kingdom. American Journal of Clinical Nutrition 2012 95 3 686 693 2-s2.0-84857810659 10.3945/ajcn.111. 024133
19. Norman E. J., Urinary methylmalonic acid test may have greater value than the total homocysteine assay for screening elderly individuals for cobalamin deficiency. Clinical Chemistry 2004 50 8 1482 1483 2-s2.0-3242759066 10.1373/clinchem.2004.035790 (Pubitemid 38970677)
20. Celik T., Kardesoglu E., Iyisoy A., Ozcan O., Kilic S., Yaman H., Urinary methylmalonic acid in patients with acute myocardial infarction. Medical Principles and Practice 2009 18 3 217 222 2-s2.0-64349105596 10.1159/000204353
21. Norman E. J., Bernard M. A., Firdaus M., Nakonezny P. A., Kashner T. M., Urinary methylmalonic acid/creatinine ratio: a gold standard test for tissue vitamin B12 deficiency. Journal of the American Geriatrics Society 1999 47 9 1158 1159 2-s2.0-0032860897 (Pubitemid 29420632)
22. Rota E., Quadri R., Fanti E., Isoardo G., Poglio F., Tavella A., Paolasso I., Ciaramitaro P., Bergamasco B., Cocito D., Electrophysiological findings of peripheral neuropathy in newly diagnosed type II diabetes mellitus. Journal of the Peripheral Nervous System 2005 10 4 348 353 2-s2.0-33644848135 10.1111/j.1085-9489.2005.00046.x
23. Acosta J. A., Hoffman S. N., Raynor E. M., Nardin R. A., Rutkove S. B., Ulnar neuropathy in the forearm: a possible complication of diabetes mellitus. Muscle and Nerve 2003 28 1 40 45 2-s2.0-0038460819 10.1002/mus.10387 (Pubitemid 36775957)
24. Saperstein D. S., Wolfe G. I., Gronseth G. S., Nations S. P., Herbelin L. L., Bryan W. W., Barohn R. J., Challenges in the identification of cobalamin-deficiency polyneuropathy. Archives of Neurology 2003 60 9 1296 1301 2-s2.0-0042421689 10.1001/archneur.60.9.1296 (Pubitemid 37099639)