Application of kinetic modeling and competitive solvent hydrolysis in the development of a highly selective hydrolysis of a nitrile to an amide

Organic Process Research and Development

Volumn 18, Issue 3, 2014, Pages 410-416

  Niemeier, Jeffry K ^a   Rothhaar, Roger R ^a   Vicenzi, Jeffrey T ^a   Werner, John A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CYANIDES; IMPURITIES; KINETIC THEORY; SOLVENTS;

GENOTOXIC IMPURITIES; INTRINSIC SAFETY; ISOLATED YIELD; KINETIC MODELING; N-METHYL-2-PYRROLIDONE; SELECTIVE HYDROLYSIS; SODIUM HYDROXIDES; SOLVENT SYSTEM;

HYDROLYSIS;

EID: 84896980877     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op4003054     Document Type: Article

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