PPAR-γ regulates trophoblast differentiation in the BeWo cell model

PPAR Research

Volumn 2014, Issue , 2014, Pages

  Levytska, Khrystyna ^a,b   Drewlo, Sascha ^c   Baczyk, Dora ^a   Kingdom, John ^a,b,d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITRO N (4 PYRIDYL)BENZAMIDE; FORSKOLIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

ARTICLE; AUTOREGULATION; CANCER CELL CULTURE; CELL COUNT; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHORIOCARCINOMA; CONTROLLED STUDY; CYTOPLASM; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LUCIFERASE ASSAY; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION; SYNCYTIOTROPHOBLAST; TROPHOBLAST;

EID: 84896975770     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2014/637251     Document Type: Article

References (27)

1. Benirschke K., P K. K., Baergen R., Pathology of the Human Placenta 2005 5th New York, NY, USA Springer
2. Hosoya T., Takizawa K., Nitta K., Hotta Y., glial cells missing: a binary switch between neuronal and glial determination in Drosophila. Cell 1995 82 6 1025 1036 2-s2.0-0029087476
3. Anson-Cartwright L., Dawson K., Holmyard D., Fisher S. J., Lazzarini R. A., Cross J. C., The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Nature Genetics 2000 25 3 311 314 2-s2.0-0033935126 10.1038/77076 (Pubitemid 30437319)
4. Bainbridge S. A., Minhas A., Whiteley K. J., Qu D., Sled J. G., Kingdom J. C. P., Adamson S. L., Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice. Hypertension 2012 59 3 732 739 2-s2.0-84857614491 10.1161/HYPERTENSIONAHA.111. 183939
5. Baczyk D., Drewlo S., Proctor L., Dunk C., Lye S., Kingdom J., Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast. Cell Death and Differentiation 2009 16 5 719 727 2-s2.0-67349255287 10.1038/cdd.2009.1
6. Baczyk D., Satkunaratnam A., Nait-Oumesmar B., Huppertz B., Cross J. C., Kingdom J. C. P., Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta. Placenta 2004 25 6 553 559 2-s2.0-2542627351 10.1016/j.placenta.2003.12.004 (Pubitemid 38701899)
7. Chen C.-P., Chen C.-Y., Yang Y.-C., Su T.-H., Chen H., Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia. Placenta 2004 25 5 413 421 2-s2.0-1942539882 10.1016/j.placenta.2003.10.014 (Pubitemid 38519115)
8. Walker M. G., Fitzgerald B., Keating S., Ray J. G., Windrim R., Kingdom J. C. P., Sex-specific basis of severe placental dysfunction leading to extreme preterm delivery. Placenta 2012 33 7 568 571 2-s2.0-84859628514 10.1016/j.placenta.2012.03.011
9. Parast M. M., Yu H., Ciric A., Salata M. W., Davis V., Milstone D. S., PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PloS ONE 2009 4 11, article e8055 10.1371/journal.pone.0008055 2-s2.0-77951251429
10. Ruebner M., Langbein M., Strissel P. L., Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARgamma/RXRalpha in placentogenesis. Journal of Cellular Biochemistry 2012 113 7 2383 2396
11. Barak Y., Nelson M. C., Ong E. S., Jones Y. Z., Ruiz-Lozano P., Chien K. R., Koder A., Evans R. M., PPAR γ is required for placental, cardiac, and adipose tissue development. Molecular Cell 1999 4 4 585 595 2-s2.0-0033213637 10.1016/S1097-2765(00)80209-9 (Pubitemid 29531138)
12. Lehmann J. M., Moore L. B., Smith-Oliver T. A., Wilkison W. O., Willson T. M., Kliewer S. A., An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ). Journal of Biological Chemistry 1995 270 22 12953 12956 2-s2.0-0029016829 10.1074/jbc.270.22.12953
13. Lee G., Elwood F., McNally J., Weiszmann J., Lindstrom M., Amaral K., Nakamura M., Miao S., Cao P., Marc Learned R., Chen J.-L., Li Y., T0070907, a selective ligand for peroxisome proliferator-activated receptor γ functions as an antagonist of biochemical and cellular activities. Journal of Biological Chemistry 2002 277 22 19649 19657 2-s2.0-18844467411 10.1074/jbc.M200743200 (Pubitemid 34967479)
14. McCarthy F. P., Drewlo S., Kingdom J., Johns E. J., Walsh S. K., Kenny L. C., Peroxisome proliferator-activated receptor- γ as a potential therapeutic target in the treatment of preeclampsia. Hypertension 2011 58 2 280 286 2-s2.0-80051471606 10.1161/HYPERTENSIONAHA.111.172627
15. Ortiz De Montellano P. R., The mechanism of heme oxygenase. Current Opinion in Chemical Biology 2000 4 2 221 227 2-s2.0-0034108816 10.1016/S1367-5931(99)00079-4 (Pubitemid 30189315)
16. Bilban M., Haslinger P., Prast J., Klinglmüller F., Woelfel T., Haider S., Sachs A., Otterbein L. E., Desoye G., Hiden U., Wagner O., Knöfler M., Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor γ Endocrinology 2009 150 2 1000 1013 2-s2.0-59649093035 10.1210/en.2008-0456
17. Kliman H. J., Nestler J. E., Sermasi E., Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986 118 4 1567 1582 2-s2.0-0022527203 (Pubitemid 16078536)
18. Knerr I., Schubert S. W., Wich C., Amann K., Aigner T., Vogler T., Jung R., Dötsch J., Rascher W., Hashemolhosseini S., Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions. FEBS Letters 2005 579 18 3991 3998 2-s2.0-21844455753 10.1016/j.febslet.2005.06.029 (Pubitemid 40961901)
19. Deng T., Sieglaff D. H., Zhang A., Lyon C. J., Ayers S. D., Cvoro A., Gupte A. A., Xia X., Baxter J. D., Webb P., Hsueh W. A., A peroxisome proliferator-activated receptor γ (PPAR γ)/PPAR γ coactivator 1 β autoregulatory loop in adipocyte mitochondrial function. Journal of Biological Chemistry 2011 286 35 30723 30731 2-s2.0-80052213436 10.1074/jbc.M111.251926
20. Hondares E., Mora O., Yubero P., De La Concepción M. R., Iglesias R., Giralt M., Villarroya F., Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1 gene transcription: an autoregulatory loop controls PGC-1 expression in adipocytes via peroxisome proliferator-activated receptor- γ coactivation. Endocrinology 2006 147 6 2829 2838 2-s2.0-33646782581 10.1210/en.2006-0070 (Pubitemid 43764595)
21. Laffitte B. A., Joseph S. B., Walczak R., Pei L., Wilpitz D. C., Collins J. L., Tontonoz P., Autoregulation of the human liver X receptor promoter. Molecular and Cellular Biology 2001 21 22 7558 7568 2-s2.0-0034773966 10.1128/MCB.21.22.7558-7568.2001 (Pubitemid 32988767)
22. Knabl J., Hüttenbrenner R., Hutter S., Peroxisome proliferator-activated receptor-gamma (PPARgamma) is down regulated in trophoblast cells of gestational diabetes mellitus (GDM) and in trophoblast tumour cells BeWo in vitro after stimulation with PPARgamma agonists. Journal of Perinatal Medicine 2013 1 9 10.1515/jpm-2013-0039
23. Franco C., Walker M., Robertson J., Fitzgerald B., Keating S., McLeod A., Kingdom J. C. P., Placental infarction and thrombophilia. Obstetrics and Gynecology 2011 117 4 929 934 2-s2.0-79953183661 10.1097/AOG.0b013e31820ca040
24. Longtine M. S., Chen B., Odibo A. O., Zhong Y., Nelson D. M., Villous trophoblast apoptosis is elevated and restricted to cytotrophoblasts in pregnancies complicated by preeclampsia, IUGR, or preeclampsia with IUGR. Placenta 2012 33 5 352 359 2-s2.0-84859156600 10.1016/j.placenta.2012.01.017
25. Fitzgerald B., Levytska K., Kingdom J., Walker M., Baczyk D., Keating S., Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A. Placenta 2011 32 4 339 345 2-s2.0-79952737487 10.1016/j.placenta.2011.01.018
26. McCarthy F. P., Drewlo S., English F. A., Kingdom J., Johns E. J., Kenny L. C., Walsh S. K., Evidence implicating peroxisome proliferator-activated receptor-gamma In the pathogenesis of preeclampsia. Hypertension 2011 58 5 882 887 2-s2.0-83155175246 10.1161/HYPERTENSIONAHA.111.179440
27. Julian C. G., Yang I. V., Browne V. A., Inhibition of peroxisome proliferator-activated receptor gamma: a potential link between chronic maternal hypoxia and impaired fetal growth. The FASEB Journal 2013 10.1096/fj.13-239749