Is methylene diphosphonate bone scan necessary for initial staging of Ewing sarcoma if18F-FDG PET/CT is performed?

American Journal of Roentgenology

Volumn 202, Issue 4, 2014, Pages 859-867

  Ulaner, Gary A ^a,b   Magnan, Heather ^a,b   Healey, John H ^a,b   Weber, Wolfgang A ^a,b   Meyers, Paul A ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Ewing sarcoma; FDG PET CT; MDP bone scan; Metastases; Staging

Indexed keywords

FLUORODEOXYGLUCOSE F 18; MEDRONATE TECHNETIUM TC 99M;

ADULT; ARTICLE; BONE METASTASIS; BONE SCINTISCANNING; CANCER STAGING; CHILD; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC VALUE; EWING SARCOMA; FALSE NEGATIVE RESULT; FOLLOW UP; HUMAN; IMAGE ANALYSIS; LUNG METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRESCHOOL CHILD; PRIMARY TUMOR; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOFT TISSUE TUMOR; VEIN THROMBOSIS;

ADOLESCENT; ADULT; BONE DENSITY CONSERVATION AGENTS; BONE NEOPLASMS; CHILD; DIPHOSPHONATES; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MALE; MULTIMODAL IMAGING; NEOPLASM STAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RETROSPECTIVE STUDIES; SARCOMA, EWING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84896972024     PISSN: 0361803X     EISSN: 15463141     Source Type: Journal    
DOI: 10.2214/AJR.13.11239     Document Type: Article

References (21)

1. Potratz J, Dirksen U, Jürgens H, Craft A. Ewing sarcoma: clinical state-of-the-art. Pediatr Hematol Oncol 2012; 29:1-11
2. Grier HE. The Ewing family of tumors: Ewing's sarcoma and primitive neuroectodermal tumors. Pediatr Clin North Am 1997; 44:991-1004
3. Paulussen M, Ahrens S, Burdach S, et al.; European Intergroup Cooperative Ewing Sarcoma Studies (EICESS). Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. Ann Oncol 1998; 9:275-281 (Pubitemid 28186797)
4. Bernstein ML, Devidas M, Lafreniere D, et al. Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457-a report from the Children's Oncology Group. J Clin Oncol 2006; 24:152-159 (Pubitemid 46630507)
5. Völker T, Denecke T, Steffen I, et al. Positron emission tomography for staging of pediatric sarcoma patients: results of a prospective multicenter trial. J Clin Oncol 2007; 25:5435-5441 (Pubitemid 350232220)
6. Reinus WR, Gehan EA, Gilula LA, Nesbit M. Plain radiographic predictors of survival in treated Ewing's sarcoma. IESS Committee. Skeletal Radiol 1992; 21:287-291
7. National Comprehensive Cancer Network. Ewing's sarcoma family of tumors. In: NCCN clinical practice guidelines in oncology (NCCN Guidelines®): bone cancer, version 1.2014. www.nccn.org/professionals/physician-gls/pdf/bone.pdf. Published September 24, 2013. Accessed December 12, 2013
8. Meyer JS, Nadel HR, Marina N, et al. Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer 2008; 51:163-170 (Pubitemid 351874407)
9. Györke T, Zajic T, Lange A, et al. Impact of FDG PET for staging of Ewing sarcomas and primitive neuroectodermal tumours. Nucl Med Commun 2006; 27:17-24 (Pubitemid 44391835)
10. Furth C, Amthauer H, Denecke T, Ruf J, Henze G, Gutberlet M. Impact of whole-body MRI and FDG-PET on staging and assessment of therapy response in a patient with Ewing sarcoma. Pediatr Blood Cancer 2006; 47:607-611 (Pubitemid 44360062)
11. Daldrup-Link HE, Franzius C, Link TM, et al. Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. AJR 2001; 177:229-236 (Pubitemid 32578088)
12. Franzius C, Sciuk J, Daldrup-Link HE, Jürgens H, Schober O. FDG-PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy. Eur J Nucl Med 2000; 27:1305-1311
13. Walter F, Czernin J, Hall T, et al. Is there a need for dedicated bone imaging in addition to 18F-FDG PET/CT imaging in pediatric sarcoma patients? J Pediatr Hematol Oncol 2012; 34:131-136
14. Treglia G, Salsano M, Stefanelli A, Mattoli MV, Giordano A, Bonomo L. Diagnostic accuracy of 18F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis. Skeletal Radiol 2012; 41:249-256
15. Newman EN, Jones RL, Hawkins DS. An evaluation of [F-18]-fluorodeoxy-D- glucose positron emission tomography, bone scan, and bone marrow aspiration/biopsy as staging investigations in Ewing sarcoma. Pediatr Blood Cancer 2013; 60:1113-1117
16. Gerth HU, Juergens KU, Dirksen U, Gerss J, Schober O, Franzius C. Significant benefit of multimodal imaging: PET/CT compared with PET alone in staging and follow-up of patients with Ewing tumors. J Nucl Med 2007; 48:1932-1939 (Pubitemid 350237602)
17. Tateishi U, Yamaguchi U, Seki K, Terauchi T, Arai Y, Kim EE. Bone and soft-tissue sarcoma: preoperative staging with fluorine 18 fluorodeoxyglucose PET/CT and conventional imaging. Radiology 2007; 245:839-847 (Pubitemid 350127355)
18. Franzius C, Daldrup-Link HE, Sciuk J, et al. FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: comparison with spiral CT. Ann Oncol 2001; 12:479-486 (Pubitemid 32472101)
19. Charest M, Hickeson M, Lisbona R, Novales-Diaz JA, Derbekyan V, Turcotte RE. FDG PET/CT imaging in primary osseous and soft tissue sarcomas: a retrospective review of 212 cases. Eur J Nucl Med Mol Imaging 2009; 36:1944-1951
20. Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I. Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol 1998; 16:3375-3379 (Pubitemid 28481635)
21. Kaste SC. Imaging pediatric bone sarcomas. Radiol Clin North Am 2011; 49:749-765, vi-vii