Expression of SLC2A9 isoforms in the kidney and their localization in polarized epithelial cells

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Kimura, Toru ^a   Takahashi, Michi ^a   Yan, Kunimasa ^a   Sakurai, Hiroyuki ^a  

^a KYORIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ISOPROTEIN; LEUCINE; SLC2A9 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELLULAR DISTRIBUTION; EPITHELIUM CELL; GENE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KIDNEY; KIDNEY COLLECTING TUBULE; KIDNEY PROXIMAL TUBULE; LYSOSOME; MDCK CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; SLC2A9 GENE; WILD TYPE;

ALTERNATIVE SPLICING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; INTRACELLULAR SPACE; KIDNEY; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN ISOFORMS; PROTEIN TRANSPORT; SEQUENCE DELETION;

EID: 84896963895     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084996     Document Type: Article

References (26)

1. Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, et al. (2010) Genomewide association study of hematological and biochemical traits in a Japanese population. Nat Genet 42: 210-215.
2. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, et al. (2009) Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 5: e1000504.
3. Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, et al. (2013) Genomewide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 45: 145-154.
4. Li S, Sanna S, Maschio A, Busonero F, Usala G, et al. (2007) The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 3: e194.
5. Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, et al. (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40: 437-442. (Pubitemid 351450879)
6. Phay JE, Hussain HB, Moley JF (2000) Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). Genomics 66: 217-220. (Pubitemid 30429757)
7. Augustin R, Carayannopoulos MO, Dowd LO, Phay JE, Moley JF, et al. (2004) Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. J Biol Chem 279: 16229-16236. (Pubitemid 38509316)
8. Anzai N, Ichida K, Jutabha P, Kimura T, Babu E, et al. (2008) Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem 283: 26834-26838.
9. Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, et al. (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Med 5: e197.
10. Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, et al. (2008) Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am J Hum Genet 83: 744-751.
11. Dinour D, Gray NK, Campbell S, Shu X, Sawyer L, et al. (2010) Homozygous SLC2A9 mutations cause severe renal hypouricemia. J Am Soc Nephrol 21: 64- 72.
12. Dinour D, Gray NK, Ganon L, Knox AJ, Shalev H, et al. (2012) Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2. Nephrol Dial Transplant 27: 1035-1041.
13. Stiburkova B, Ichida K, Sebesta I (2011) Novel homozygous insertion in SLC2A9 gene caused renal hypouricemia. Mol Genet Metab 102: 430-435.
14. Stiburkova B, Taylor J, Marinaki AM, Sebesta I (2012) Acute kidney injury in two children caused by renal hypouricaemia type 2. Pediatr Nephrol 27: 1411- 1415.
15. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, et al. (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417: 447-452. (Pubitemid 34563537)
16. Kimura T, Amonpatumrat S, Tsukada A, Fukutomi T, Jutabha P, et al. (2011) Increased expression of SLC2A9 decreases urate excretion from the kidney. Nucleosides Nucleotides Nucleic Acids 30: 1295-1301.
17. Manolescu AR, Augustin R, Moley K, Cheeseman C (2007) A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. Mol Membr Biol 24: 455-463. (Pubitemid 47290684)
18. Witkowska K, Smith KM, Yao SY, Ng AM, O'Neill D, et al. (2012) Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses. Am J Physiol Renal Physiol 303: F527-539.
19. Bibee KP, Augustin R, Gazit V, Moley KH (2013) The apical sorting signal for human GLUT9b resides in the N-terminus. Mol Cell Biochem 376: 163-173.
20. Preitner F, Bonny O, Laverriere A, Rotman S, Firsov D, et al. (2009) Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci U S A 106: 15501- 15506.
21. Carmosino M, Gimenez I, Caplan M, Forbush B (2008) Exon loss accounts for differential sorting of Na-K-Cl cotransporters in polarized epithelial cells. Mol Biol Cell 19: 4341-4351.
22. Mangravite LM, Xiao G, Giacomini KM (2003) Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am J Physiol Renal Physiol 284: F902-910. (Pubitemid 36443574)
23. Regeer RR, Markovich D (2004) A dileucine motif targets the sulfate anion transporter sat-1 to the basolateral membrane in renal cell lines. Am J Physiol Cell Physiol 287: C365-372. (Pubitemid 38955227)
24. Lisinski I, Schurmann A, Joost HG, Cushman SW, Al-Hasani H (2001) Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells. Biochem J 358: 517-522. (Pubitemid 32826371)
25. Schmidt U, Briese S, Leicht K, Schurmann A, Joost HG, et al. (2006) Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex. J Cell Sci 119: 2321-2331. (Pubitemid 43960321)
26. Zhao X, Deak E, Soderberg K, Linehan M, Spezzano D, et al. (2003) Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med 197: 153-162. (Pubitemid 36152310)