Steroid metabolome in the umbilical cord: Is it necessary to differentiate between arterial and venous blood?

Physiological Research

Volumn 63, Issue 1, 2014, Pages 115-126

  Paskova A ^a   Pařízek, Antonín ^a   Hill, M ^b   Velikova M ^b   Kubatova J ^b   Duskova M ^b   Adamcova K ^a   Koucky M ^a   Simjak P ^a   Cerny A ^a   Starka L ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

Author keywords

Blood; GC MS; Labor; Metabolome; Steroids

Indexed keywords

STEROID;

ADULT; BLOOD; COMPARATIVE STUDY; FEMALE; FETUS BLOOD; HUMAN; METABOLISM; METABOLOME; NEWBORN; PHYSIOLOGY; PREGNANCY; PREMATURITY; UMBILICAL ARTERY; UMBILICAL CORD; UMBILICAL VEIN; YOUNG ADULT;

ADULT; FEMALE; FETAL BLOOD; HUMANS; INFANT, NEWBORN; METABOLOME; PREGNANCY; PREMATURE BIRTH; STEROIDS; UMBILICAL ARTERIES; UMBILICAL CORD; UMBILICAL VEINS; YOUNG ADULT;

EID: 84896946893     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. BAIK I, DEVITO WJ, BALLEN K, BECKER PS, OKULICZ W, LIU Q, DELPAPA E, LAGIOU P, STURGEON S, TRICHOPOULOS D, QUESENBERRY PJ, HSIEH CC: Association of fetal hormone levels with stem cell potential: evidence for early life roots of human cancer. Cancer Res 65: 358-363, 2005.
2. BULUN SE, CHENG YH, PAVONE ME, YIN P, IMIR G, UTSUNOMIYA H, THUNG S, XUE Q, MARSH EE, TOKUNAGA H, ISHIKAWA H, KURITA T, SU EJ: 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis. Semin Reprod Med 28: 44-50, 2010.
3. BYRNS MC: Role of aldo-keto reductase enzymes in mediating the timing of parturition. Front Pharmacol 2: 92, 2011.
4. CAVARZERE P, SAMARA-BOUSTANI D, FLECHTNER I, DECHAUX M, ELIE C, TARDY V, MOREL Y, POLAK M: Transient hyper-17-hydroxyprogesteronemia: a clinical subgroup of patients diagnosed at neonatal screening for congenital adrenal hyperplasia. Eur J Endocrinol 161: 285-292, 2009.
5. CHEON CK: Practical approach to steroid 5alpha-reductase type 2 deficiency. Eur J Pediatr 170: 1-8, 2011.
6. HILL M, PARIZEK A, CIBULA D, KANCHEVA R, JIRASEK JE, JIRKOVSKA M, VELIKOVA M, KUBATOVA J, KLIMKOVA M, PASKOVA A, ZIZKA Z, KANCHEVA L, KAZIHNITKOVA H, ZAMRAZILOVA L, STARKA L: Steroid metabolome in fetal and maternal body fluids in human late pregnancy. J Steroid Biochem Mol Biol 122: 114-132, 2010a.
7. HILL M, PARIZEK A, KANCHEVA R, DUSKOVA M, VELIKOVA M, KRIZ L, KLIMKOVA M, PASKOVA A, ZIZKA Z, MATUCHA P, MELOUN M, STARKA L: Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor. J Steroid Biochem Mol Biol 121: 594-610, 2010b.
8. HILL M, PARIZEK A, VELIKOVA M, KUBATOVA J, KANCHEVA R, DUSKOVA M, SIMUNKOVA K, KLIMKOVA M, PASKOVA A, ZIZKA Z, JIRASEK JE, JIRKOVSKA M, STARKA L: The distribution of placental oxidoreductase isoforms provides different milieus of steroids influencing pregnancy in the maternal and fetal compartment. Horm Mol Biol Clin Invest 4: 581-600, 2011.
9. HINES M: Prenatal endocrine influences on sexual orientation and on sexually differentiated childhood behavior. Front Neuroendocrinol 32: 170-182, 2011.
10. JARI SD, FRAER LM, HOGGE WA: Association of undetectable unconjugated estriol on multiple marker screening with steroid sulfatase deficiency. Fetal Diagn Ther 19: 43-48, 2004.
11. LYKKESFELDT G, LYKKESFELDT AE, SKAKKEBAEK NE: Steroid sulphatase in man: a non inactivated X-locus with partial gene dosage compensation. Hum Genet 65: 355-357, 1984.
12. MAZOR M, HERSHKOVITZ R, CHAIM W, LEVY J, SHARONY Y, LEIBERMAN JR, GLEZERMAN M: Human preterm birth is associated with systemic and local changes in progesterone/17 beta-estradiol ratios. Am J Obstet Gynecol 171: 231-236, 1994.
13. MILLER WL: The syndrome of 17,20 lyase deficiency. J Clin Endocrinol Metab 97: 59-67, 2012.
14. MINDNICH R, DRURY JE, PENNING TM: The effect of disease associated point mutations on 5beta-reductase (AKR1D1) enzyme function. Chem Biol Interact 191: 250-254, 2011.
15. NORDENSTROM A, FOREST MG, WEDELL A: A case of 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) deficiency picked up by neonatal screening for 21-hydroxylase deficiency: difficulties and delay in etiologic diagnosis. Horm Res 68: 204-208, 2007.
16. PADMANABHAN V, VEIGA-LOPEZ A: Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming. Semin Reprod Med 29: 173-186, 2011.
17. PLUCHINO N, CUBEDDU A, GIANNINI A, MERLINI S, CELA V, ANGIONI S, GENAZZANI AR: Progestogens and brain: an update. Maturitas 62: 349-355, 2009.
18. PLUCHINO N, SANTORO A, CASAROSA E, WENGER JM, GENAZZANI AD, PETIGNAT P, GENAZZANI AR: Advances in neurosteroids: role in clinical practice. Climacteric 16 (Suppl 1): 8-17, 2013.
19. POWER ML, SCHULKIN J: Functions of corticotropin-releasing hormone in anthropoid primates: from brain to placenta. Am J Hum Biol 18: 431-447, 2006.
20. SHACKLETON C, MALUNOWICZ E: Apparent pregnene hydroxylation deficiency (APHD): seeking the parentage of an orphan metabolome. Steroids 68: 707-717, 2003.
21. SHACKLETON C, MARCOS J, ARLT W, HAUFFA BP: Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype. Am J Med Genet A 129A: 105-112, 2004.
22. TODD BJ, SCHWARZ JM, MONG JA, MCCARTHY MM: Glutamate AMPA/kainate receptors, not GABA(A) receptors, mediate estradiol-induced sex differences in the hypothalamus. Dev Neurobiol 67: 304-315, 2007.
23. TROISI R, LAGIOU P, TRICHOPOULOS D, XU B, CHIE L, STANCZYK FZ, POTISCHMAN N, ADAMI HO, HOOVER RN, HSIEH CC: Cord serum estrogens, androgens, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 in Chinese and U.S. Caucasian neonates. Cancer Epidemiol Biomarkers Prev 17: 224-231, 2008.
24. WARD AM, SYDDALL HE, WOOD PJ, CHROUSOS GP, PHILLIPS DI: Fetal programming of the hypothalamicpituitary-adrenal (HPA) axis: low birth weight and central HPA regulation. J Clin Endocrinol Metab 89: 1227-1233, 2004.
25. YANG SY, HE XY, MILLER D: HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids. Mol Genet Metab 92: 36-42, 2007.
26. YAWNO T, HIRST JJ, CASTILLO-MELENDEZ M, WALKER DW: Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain. Neuroscience 163: 838-847, 2009.