Anti-transforming growth factor-β therapy in patients with myelofibrosis

Leukemia and Lymphoma

Volumn 55, Issue 2, 2014, Pages 450-452

  Mascarenhas, John ^a   Li, Timmy ^a   Sandy, Lonette ^a   Newsom, Carrie ^a   Petersen, Bruce ^a   Godbold, James ^a   Hoffman, Ronald ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRESOLIMUMAB; PADGEM PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; BAUERMEISTER SCALE; CASE REPORT; DERMATITIS; DRUG ACCUMULATION; DRUG DOSE ESCALATION; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; HEART ARREST; HERPES ZOSTER; HUMAN; HYPOXIA; IMMUNOTHERAPY; KERATOACANTHOMA; LETTER; LEUKOCYTOSIS; LEUKOPENIA; MALE; MAXIMUM PLASMA CONCENTRATION; MIDDLE AGED; MULTIPLE CYCLE TREATMENT; MYELOFIBROSIS; MYELOID METAPLASIA; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; OPEN STUDY; PHASE 1 CLINICAL TRIAL; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PUNCH BIOPSY; SKIN CANCER; SKIN DEFECT; THROMBOCYTHEMIA; TREATMENT RESPONSE;

AGED; ANTIBODIES, MONOCLONAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EXANTHEMA; FATIGUE; FEMALE; HUMANS; MALE; MIDDLE AGED; PRIMARY MYELOFIBROSIS; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 84896935958     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2013.805329     Document Type: Letter

References (16)

1. Ciurea SO, Merchant D, Mahmud N., et al Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis. Blood 2007;110:986-993. (Pubitemid 47267438)
2. Le Bousse-Kerdiles MC, Martyre MC. Dual implication of fibrogenic cytokines in the pathogenesis of fibrosis and myeloproliferation in myeloid metaplasia with myelofibrosis. Ann Hematol 1999;78: 437-444. (Pubitemid 29504978)
3. Thiele J, Kvasnicka HM, Dietrich H, et al Dynamics of bone marrow changes in patients with chronic idiopathic myelofibrosis following allogeneic stem cell transplantation. Histol Histopathol 2005;20: 879-889. (Pubitemid 40932606)
4. Sale GE, Deeg HJ, Porter BA Regression of myelofibrosis and osteosclerosis following hematopoietic cell transplantation assessed by magnetic resonance imaging and histologic grading. Biol Blood Marrow Transplant 2006;12:1285-1294. (Pubitemid 44858258)
5. Udomsakdi-Auewarakul C., Visuthisakchai S, Sangruchi T., et al Reversal of marrow fibrosis in agnogenic myeloid metaplasia by allogeneic peripheral blood stem cell transplantation. Asian Pac J Allergy Immunol 2003;21:121-126. (Pubitemid 37406689)
6. Massague J. TGFbeta in cancer. Cell 2008;134:215-230.
7. Thiele J, Kvasnicka HM Grade of bone marrow fibrosis is associated with relevant hematological findings-a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis. Ann Hematol 2006;85:226-232.
8. Gianelli U, Vener C, Bossi A., et al The European Consensus on grading of bone marrow fibrosis allows a better prognostication of patients with primary myelofibrosis. Mod Pathol 2012;25:1193-1202.
9. Wang JC, Chang TH, Goldberg A, et al Quantitative analysis of growth factor production in the mechanism of fibrosis in agnogenic myeloid metaplasia. Exp Hematol 2006;34:1617-1623. (Pubitemid 44838997)
10. Vannucchi AM, Bianchi L, Paoletti F., et al A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-betal in the development of myelofibrosis. Blood 2005;105:3493-3501. (Pubitemid 40628191)
11. Schmitt A, Drouin A, Masse J.M., et al Polymorphonuclear neutrophil and megakaryocyte mutual involvement in myelofibrosis pathogenesis. Leuk Lymphoma 2002;43:719-724. (Pubitemid 34428658)
12. Morris JC, Shapiro GI, Tan A.R., et al Phase I/II study of GC1008: a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC). J Clin Oncol 2008;26(15 Suppl.): Abstract 9028.
13. Cervantes F, Dupriez B, Pereira A., et al New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood 2009;113:2895-2901.
14. Bauermeister DE. Quantitation of bone marrow reticulin-a normal range. Am J Clin Pathol 1971;56:24-31.
15. Thiele J, Kvasnicka HM, Facchetti F, et al European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica 2005;90:1128-1132. (Pubitemid 41323513)
16. Manoharan A, Horsley R, Pitney WR The reticulin content of bone marrow in acute leukaemia in adults. Br J Haematol 1979;43:185-190. (Pubitemid 10243277)