Long-term effects of maximally intensive statin therapy on changes in coronary atheroma composition: Insights from SATURN

European Heart Journal Cardiovascular Imaging

Volumn 15, Issue 4, 2014, Pages 380-388

  Puri, Rishi ^a   Libby, Peter ^b   Nissen, Steven E ^a   Wolski, Kathy ^a   Ballantyne, Christie M ^c   Barter, Phillip J ^d   Chapman, M John ^e   Erbel, Raimund ^f   Raichlen, Joel S ^g   Uno, Kiyoko ^h   Kataoka, Yu ^h   Tuzcu, E Murat ^a   Nicholls, Stephen J ^b,h  

^a LERNER RESEARCH INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d HEART RESEARCH INSTITUTE   (Australia)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f West German Heart Center   (Germany)

^g ASTRAZENECA   (United Kingdom)

^h UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Atherosclerosis; IVUS; Plaque composition; Statins; Virtual Histology

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ROSUVASTATIN; BIOLOGICAL MARKER; FLUOROBENZENE; HEPTANOIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; SULFONAMIDE;

ADIPOSE TISSUE; ADULT; AGED; ARTERY INTIMA PROLIFERATION; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ATHEROMA; DISEASE ASSOCIATION; DRUG THERAPY; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; INTRAVASCULAR ULTRASOUND; INTRAVASCULAR ULTRASOUND CATHETER; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MAXIMALLY INTENSIVE STATIN THERAPY; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REDUCTION; ATHEROSCLEROTIC PLAQUE; BLOOD; CORONARY ARTERY DISEASE; DRUG EFFECTS; ECHOGRAPHY; ENDOSCOPIC ECHOGRAPHY; INTIMA; METABOLISM; METHODOLOGY; PATHOLOGY; PROCEDURES; RISK FACTOR; TIME; TREATMENT OUTCOME;

AGED; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; FEMALE; FLUOROBENZENES; FOLLOW-UP STUDIES; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PLAQUE, ATHEROSCLEROTIC; PYRIMIDINES; PYRROLES; RESEARCH DESIGN; RISK FACTORS; SULFONAMIDES; TIME FACTORS; TREATMENT OUTCOME; TUNICA INTIMA; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 84896925167     PISSN: 20472404     EISSN: None     Source Type: Journal    
DOI: 10.1093/ehjci/jet251     Document Type: Article

References (48)

1. Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N et al. Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010;376:1670-81
2. Nissen SE, Tuzcu EM, Schoenhagen P, Brown BG, Ganz P, Vogel RA et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: A randomized controlled trial. JAMA 2004;291:1071-80
3. Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, BallantyneCMet al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: The ASTEROID trial. JAMA 2006;295:1556-65
4. Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P et al. Effect of two intensive statin regimens on progression of coronary disease.NEngl J Med 2011; 365:2078-87
5. Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 2001;21:1712-9
6. Aikawa M, Rabkin E, Sugiyama S, Voglic SJ, Fukumoto Y, Furukawa Y et al. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation 2001;103:276-83
7. Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease.NEngl J Med 2005; 352:29-38
8. Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe Ch et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005; 352:20-8
9. Nicholls SJ, Tuzcu EM, Sipahi I, Grasso AW, Schoenhagen P, Hu T et al. Statins, highdensity lipoprotein cholesterol, and regression of coronary atherosclerosis. JAMA 2007;297:499-508
10. Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 2002;106:2200-6
11. Nicholls SJ, Borgman M, Nissen SE, Raichlen JS, Ballantyne C, Barter P et al. Impact of statins on progression of atherosclerosis: Rationale and design of SATURN (Study of coronary Atheroma by inTravascular Ultrasound: Effect of Rosuvastatin vs atorvastatiN). Curr Med Res Opin 2011;27:1119-29
12. Atkinson KE. An Introduction to Numerical Analysis. 2nd ed. New York: John Wiley and Sons; 1989
13. Garcia-Garcia HM, Mintz GS, Lerman A, Vince DG, Margolis MP, van Es GA et al. Tissue characterisation using intravascular radiofrequency data analysis: Recommendations for acquisition, analysis, interpretation and reporting. EuroIntervention 2009; 5:177-89
14. Kubo T, Maehara A, Mintz GS, Doi H, Tsujita K, Choi SY et al. The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. J Am Coll Cardiol 2010;55:1590-7
15. Maehara A, Cristea E, Mintz GS, Lansky AJ, Dressler O, Biro S et al. Definitions and methodology for the grayscale and radiofrequency intravascular ultrasound and coronary angiographic analyses. JACC Cardiovasc Imaging 2012;5:S1-9
16. Vaughan CJ, GottoAMJr, BassonCT. The evolving role of statins in the management of atherosclerosis. J Am Coll Cardiol 2000;35:1-10
17. Libby P, AikawaM. Mechanisms of plaque stabilization with statins. Am J Cardiol 2003; 91:4B-8B.
18. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE et al. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: A potential mechanism of lesion stabilization. Circulation 1998;97:2433-44
19. Crisby M, Nordin-Fredriksson G, Shah PK, Yano J, Zhu J, Nilsson J. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization. Circulation 2001;103:926-33
20. Underhill HR, Yuan C, Zhao XQ, Kraiss LW, Parker DL, Saam T et al. Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial. Am Heart J 2008;155:584, e1-8
21. Okazaki S, Yokoyama T, Miyauchi K, Shimada K, Kurata T, Sato H et al. Early statin treatment in patients with acute coronary syndrome: Demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: The ESTABLISH Study. Circulation 2004;110:1061-8
22. Kawasaki M, Sano K, Okubo M, Yokoyama H, Ito Y, Murata I et al. Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three-dimensional integrated backscatter intravascular ultrasound. J Am Coll Cardiol 2005;45:1946-53
23. Nasu K, Tsuchikane E, Katoh O, Tanaka N, Kimura M, Ehara M et al. Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound. JACC Cardiovasc Intervent 2009;2:689-96
24. Hong MK, ParkDW, LeeCW, LeeSW, Kim YH, KangDHet al. Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis. JACC Cardiovasc Intervent 2009;2:679-88
25. Eshtehardi P, McDaniel MC, Dhawan SS, Binongo JN, Krishnan SK, Golub L et al. Effect of intensive atorvastatin therapy on coronary atherosclerosis progression, composition, arterial remodeling, and microvascular function. J Invasive Cardiol 2012;24:522-9
26. Nair A, Margolis MP, Kuban BD, Vince DG. Automated coronary plaque characterisation with intravascular ultrasound backscatter: Ex vivo validation. EuroIntervention 2007;3:113-20
27. Kolodgie FD, Virmani R, Burke AP, Farb A, Weber DK, Kutys R et al. Pathologic assessment of the vulnerable human coronary plaque. Heart 2004;90:1385-91
28. Schaar JA, Muller JE, Falk E, Virmani R, Fuster V, Serruys PW et al. Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece. Eur Heart J 2004;25: 1077-82
29. Rodriguez-Granillo GA, Garcia-Garcia HM, Mc Fadden EP, Valgimigli M, Aoki J, de Feyter P et al. In vivo intravascular ultrasound-derived thin-cap fibroatheroma detection using ultrasound radiofrequency data analysis. J Am Coll Cardiol 2005;46: 2038-42
30. StoneGW, Maehara A, Lansky AJ, de Bruyne B, Cristea E, Mintz GS et al.Aprospective natural-history study of coronary atherosclerosis. N Engl J Med 2011;364: 226-35
31. Falk E, Wilensky RL. Prediction of coronary events by intravascular imaging. JACC Cardiovasc Imaging 2012;5:S38-41
32. Nakazato R, Gransar H, Berman DS, Cheng VY, Lin FY, Achenbach S et al. Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry. Atherosclerosis 2012;225:148-53
33. Sangiorgi G, Rumberger JA, Severson A, Edwards WD, Gregoire J, Fitzpatrick LA et al. Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: A histologic study of 723 coronary artery segments using nondecalcifying methodology. J Am Coll Cardiol 1998;31:126-33
34. Ehara S, Kobayashi Y, Yoshiyama M, Shimada K, Shimada Y, Fukuda D et al. Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: An intravascular ultrasound study. Circulation 2004;110:3424-9
35. Motoyama S, Kondo T, Sarai M, Sugiura A, Harigaya H, Sato T et al. Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J Am Coll Cardiol 2007;50:319-26
36. KataokaY,Wolski K,UnoK, Puri R, Tuzcu EM, Nissen SE et al. Spotty calcification as a marker of accelerated progression of coronary atherosclerosis: Insights from serial intravascular ultrasound. J Am Coll Cardiol 2012;59:1592-7
37. Maldonado N, Kelly-Arnold A, Vengrenyuk Y, Laudier D, Fallon JT, Virmani R et al. A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: Potential implications for plaque rupture. Am J Physiol Heart Circ Physiol 2012;303:H619-28
38. Bostrom K,Watson KE, Horn S,WorthamC, Herman IM, Demer LL. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 1993;91: 1800-9
39. Hirota S, Imakita M, Kohri K, Ito A, Morii E, Adachi S et al. Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcification. Am J Pathol 1993;143:1003-8
40. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH et al. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation 2007;116:2841-50
41. WuB, Elmariah S, Kaplan FS, Cheng G, Mohler ER III. Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: Implications for end-stage valvular heart disease. Arterioscler Thromb Vasc Biol 2005;25:592-7
42. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 2012;32:2045-51
43. Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol 2006;47:C13-8
44. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, CastelliWP, Knoke JD et al. Highdensity lipoprotein cholesterol and cardiovascular disease. Four prospectiveAmerican studies. Circulation 1989;79:8-15
45. Barter PJ, Nicholls S, Rye KA, Anantharamaiah GM, Navab M, Fogelman AM. Antiinflammatory properties of HDL. Circ Res 2004;95:764-72
46. Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial. JAMA 2003;290: 2292-300
47. Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.NEngl J Med 2011;364:127-35
48. Sheet D, Karamalis A, Eslami A, Noel P, Virmani R, Nakano M et al. Hunting for necrosis in the shadows of intravascular ultrasound. Comput Med Imaging Graph 2013 doi:10.1016/j.compmedimag.2013.08.002