A1 adenosine receptor deficiency or inhibition reduces atherosclerotic lesions in apolipoprotein e deficient mice

Cardiovascular Research

Volumn 102, Issue 1, 2014, Pages 157-165

  Teng, Bunyen ^a   Smith, Jonathan D ^b   Rosenfeld, Michael E ^c   Robinet, Peggy ^b   Davis, Mary E ^a   Morrison, R Ray ^d   Mustafa, S Jamal ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

1,3 Dipropyl 8 cyclopentylxanthine (DPCPX); Apolipoprotein E; Cytokines; IL 13

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; APOLIPOPROTEIN E; CHOLESTEROL; CYCLINE; INTERLEUKIN 13; INTERLEUKIN 5; INTERLEUKIN 6; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; AORTA; AORTA ARCH; AORTA ROOT; ARTICLE; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; BODY WEIGHT; BRACHIOCEPHALIC TRUNK; CELL MIGRATION; CELL MOTION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; COMPARATIVE STUDY; DRUG EFFECT; DRUG MEGADOSE; EFFUSION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GENETIC CODE; KNOCKOUT MOUSE; LIMIT OF QUANTITATION; LIPID DIET; LOW DRUG DOSE; MALE; MICROARRAY ANALYSIS; MITOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WESTERN BLOTTING; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; INFLAMMATION; MACROPHAGE; METABOLISM;

ANIMALS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; DISEASE MODELS, ANIMAL; INFLAMMATION; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ADENOSINE A1;

EID: 84896924642     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu033     Document Type: Article

References (57)

1. Wilson CN, Nadeem A, Spina D, Brown R, Page CP, Mustafa SJ. Adenosine receptors and asthma. Handb Exp Pharmacol 2009;193:329-362.
2. Kowaluk EA. Adenosine modulation: a novel approach to analgesia and inflammation. Expert Opin Investig Drugs 1998;7:535-543.
3. Shen J, Halenda SP, Sturek M, Wilden PA. Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor. Circ Res 2005;97:574-582.
4. Shen J, Halenda SP, Sturek M, Wilden PA. Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor. Circ Res 2005; 96:982-990.
5. Ramkumar V, Hallam DM, Nie Z. Adenosine, oxidative stress and cytoprotection. Jpn J Pharmacol 2001;86:265-274.
6. Hayes ES. Adenosine receptors and cardiovascular disease: the adenosine-1 receptor (A1) and A1 selective ligands. Cardiovasc Toxicol 2003;3:71-88.
7. El-Awady MS, Ansari HR, Fil D, Tilley SL, Mustafa SJ. NADPH oxidase pathwayis involved in aortic contraction induced by A3 adenosine receptor in mice. J Pharmacol Exp Ther 2011;338:711-717.
8. Wang H, Zhang W, Zhu C, Bucher C, Blazar BR, Zhang C et al. Inactivation of the Ad-enosine A2A Receptor Protects Apolipoprotein E-Deficient Mice From Atherosclerosis. Arterioscler Thromb Vasc Biol 2009;29:1046-1052.
9. Pingle SC, Jajoo S, Mukherjea D, Sniderhan LF, Jhaveri KA, Marcuzzi A et al. Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase. Mol Pharmacol 2007;72: 856-867.
10. Peyot ML, Gadeau AP, Dandre F, Belloc I, Dupuch F, Desgranges C. Extracellular adeno-sine induces apoptosis of human arterial smooth muscle cells via A(2b)-purinoceptor. Circ Res 2000;86:76-85.
11. Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA et al. A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem 2004;92:1034-1043.
12. Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis V et al. The A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation 2012;125: 354-363.
13. Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 1994;93:1885-1893.
14. Baglione J, Smith JD. Quantitative assay for mouse atherosclerosis in the aortic root. In: Wang QK, ed. Methods in Molecular Medicine, Vol 129: Cardiovascular Disease: Methods and Protocols. Totowa, NJ: Humana Press, 2006:83-95.
15. Elbadawi A. Hexachrome modification of Movat's stain. Stain Technol 1976;51:249-253.
16. Russell HK Jr. A modification of Movat's pentachrome stain. Arch Pathol 1972;94: 187-191.
17. Spayd RW, Bruschi B, Burdick BA, Dappen GM, Eikenberry JN, Esders TW et al. Multilayer film elements for clinical analysis: applications to representative chemical determinations. Clin Chem 1978;24:1343-1350.
18. Morrison RR, Teng B, Oldenburg PJ, Katwa LC, Schnermann JB, Mustafa SJ. Effects of targeted deletion ofA1adenosine receptorsonpostischemic cardiac function and expression of adenosine receptor subtypes. Am J Physiol Heart Circ Physiol 2006;291:H1875-H1882.
19. Nadeem A, Fan M, Ansari HR, Ledent C, Jamal Mustafa S. Enhanced airway reactivity and inflammationin A2A adenosine receptor-deficient allergic mice. Am JPhysiol Lung Cell Mol Physiol 2007;292:L1335-L1344.
20. Austin PE, Mc Culloch EA, Till JE. Characterization of the factor in L-cell conditioned medium capable of stimulating colony formation by mouse marrow cells in culture. J Cell Physiol 1971;77:121-134.
21. Knight KR, Vairo G, Hamilton JA. Regulation of pinocytosis in murine macrophages by colony-stimulating factors and other agents. J Leukoc Biol 1992;51:350-359.
22. Robinet P, Wang Z, Hazen SL, Smith JD. Asimple and sensitive enzymatic method for cholesterol quantification in macrophages and foam cells. J Lipid Res 2010;51:3364-3369.
23. Chandrasekharan UM, Mavrakis L, Bonfield TL, Smith JD, Di Corleto PE. Decreased atherosclerosis in mice deficient in tumor necrosis factor-alpha receptor-II (p75). Arterios-cler Thromb Vasc Biol 2007;27:e16-e17.
24. Smith JD, Peng DQ, Dansky HM, Settle M, Baglione J, Le Goff W et al. Transcriptome profile of macrophages from atherosclerosis-sensitive and atherosclerosis-resistant mice. Mamm Genome 2006;17:220-229.
25. Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis Vet al. A2b adeno-sine receptor regulates hyperlipidemia and atherosclerosis. Circulation 2012;125:354-363.
26. Jha HC, Divya A, Prasad J, Mittal A. Plasma circulatorymarkersinmale and female patients with coronary artery disease. Heart Lung 2010;39:296-303.
27. Brunetti ND, Pepe M, Munno I, Tiecco F, Quagliara D, De Gennaro L et al. Th2-dependent cytokine release in patients treated with coronary angioplasty. Coron Artery Dis 2008;19:133-137.
28. Foteinos G, Afzal AR, Mandal K, Jahangiri M, Xu Q. Anti-heat shock protein 60 autoanti-bodies induce atherosclerosisinapolipoprotein E-deficient mice via endothelial damage. Circulation 2005;112:1206-1213.
29. Blackburn MR, Lee CG, Young HW, Zhu Z, Chunn JL, Kang MJ et al. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest 2003;112:332-344.
30. Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ et al. Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix m et al loproteases, and serine proteases. J Immunol 2009; 183:1739-1750.
31. Hershey GK. IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 2003;111:677-690; quiz 691.
32. Wei LH, Jacobs AT, Morris SM Jr, Ignarro LJ. IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathwaysin vascular smooth muscle cells. Am J Physiol Cell Physiol 2000;279:C248-C256.
33. Wei LH, Yang Y, Wu G, Ignarro LJ. IL-4 and IL-13 upregulate ornithine decarboxylase expression by PI3K and MAP kinase pathways in vascular smooth muscle cells. Am J Physiol Cell Physiol 2008;294:C1198-C1205.
34. Wei LH, Wu G, Morris SM Jr, Ignarro LJ. Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci USA 2001;98: 9260-9264.
35. Moon HG, Tae YM, Kim YS, Gyu Jeon S, Oh SY, Song Gho Y et al. Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Allergy 2010;65:1093-1103.
36. 1 Adenosine Receptor Causes Inflammation and Impaired Vasorelaxationin a Murine Model of Asthma. Am J Respir Crit Care Med 2008;177:A532.
37. Tabas I, Seimon T, Timmins J, Li G, Lim W. Macrophage apoptosis in advanced atherosclerosis. Ann N Y Acad Sci 2009;1173(Suppl. 1):E40-E45.
38. Krause BR, Auerbach BJ. Reverse cholesterol transport and future pharmacological approachestothe treatmentofatherosclerosis. Curr Opin Investig Drugs 2001;2:375-381.
39. ′-cyclic adenosine monophosphate (cAMP) in atherosclerosis. Curr Vasc Pharmacol 2010;8:464-472.
40. Oram JF, Lawn RM, Garvin MR, Wade DP. ABCA1isthecAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem 2000;275: 34508-34511.
41. Reiss AB, Rahman MM, Chan ES, Montesinos MC, Awadallah NW, Cronstein BN. Ad-enosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages. J Leukoc Biol 2004;76:727-734.
42. Streitova D, Hofer M, Hola J, Vacek A, Pospisil M. Adenosine A(1), A(2a), A(2b), and A(3) receptors in hematopoiesis. 2. Expression of receptor mRNA in resting and lipopolysaccharide-activated mouse RAW 264. 7 macrophages. Physiol Res 2010;59:139-144.
43. Kara FM, Chitu V, Sloane J, Axelrod M, Fredholm BB, Stanley ER et al. Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function. FASEB J 2010;24:2325-2333.
44. Stoger JL, Goossens P, de Winther MP. Macrophage heterogeneity: relevance and functional implications in atherosclerosis. Curr Vasc Pharmacol 2010;8:233-248.
45. Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JCet al. A1adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation 2007;115:2307-2315.
46. Grden M, Podgorska M, Szutowicz A, Pawelczyk T. Diabetes-induced alterations of ad-enosine receptors expression level in rat liver. Exp Mol Pathol 2007;83:392-398.
47. Lai DM, Tu YK, Liu IM, Cheng JT. Increase of adenosine A1 receptor gene expression in cerebral ischemia of Wistar rats. Neurosci Lett 2005;387:59-61.
48. Liu IM, Tzeng TF, Tsai CC, Lai TY, Chang CT, Cheng JT. Increase in adenosine A1 receptor gene expression in the liver of streptozotocin-induced diabetic rats. Diabetes Metab Res Rev 2003;19:209-215.
49. Nie Z, Mei Y, Ford M, Rybak L, Marcuzzi A, Ren H et al. Oxidative stress increases A1 adenosine receptor expression by activating nuclear factor kappa B. Mol Pharmacol 1998;53:663-669.
50. Pawelczyk T, Grden M, Rzepko R, Sakowicz M, Szutowicz A. Region-specific alterations of adenosine receptors expression level in kidney of diabetic rat. Am J Pathol 2005;167: 315-325.
51. Rogachev B, Ziv NY, Mazar J, Nakav S, Chaimovitz C, Zlotnik M et al. Adenosine is upre-gulated during peritonitis and is involved in downregulation of inflammation. Kidney Int 2006;70:675-681.
52. Barakat H, Davis J, Lang D, Mustafa SJ, Mc Connaughey MM. Differencesin the expression of the adenosine A1 receptor in adipose tissue of obese black and white women. J Clin Endocrinol Metab 2006;91:1882-1886.
53. Dhalla AK, Wong MY, Voshol PJ, Belardinelli L, Reaven GM. A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodents. Am J Physiol Endocrinol Metab 2007;292:E1358-E1363.
54. Elzein E, Zablocki J. A1adenosine receptoragonists and their potential therapeutic applications. Expert Opin Investig Drugs 2008;17:1901-1910.
55. Hoffman BB, Dall'Aglio E, Hollenbeck C, Chang H, Reaven GM. Suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine. J Pharmacol Exp Ther 1986;239:715-718.
56. Ford MS, Maggirwar SB, Rybak LP, Whitworth C, Ramkumar V. Expression and function of adenosine receptors in the chinchilla cochlea. Hear Res 1997;105:130-140.
57. Ramkumar V, Whitworth CA, Pingle SC, Hughes LF, Rybak LP. Noise inducesA1adeno-sine receptor expression in the chinchilla cochlea. Hear Res 2004;188:47-56.