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Volumn 46, Issue 3, 2014, Pages 201-223

Chinese herb formulae for treatment of erectile dysfunction: A systematic review of randomised controlled clinical trials

Author keywords

Chinese traditional medicine; Erectile dysfunction; Systematic review

Indexed keywords

BROMOCRIPTINE; CHINESE DRUG; HERBACEOUS AGENT; MECOBALAMIN; PLACEBO; SIMVASTATIN; TESTOSTERONE UNDECANOATE; VARDENAFIL; YOHIMBINE;

EID: 84896876606     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/and.12074     Document Type: Review
Times cited : (7)

References (57)
  • 1
    • 0032810944 scopus 로고    scopus 로고
    • The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences
    • Ayta IA, McKinlay JB, Krane RJ (1999) The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU 84:50-56.
    • (1999) BJU , vol.84 , pp. 50-56
    • Ayta, I.A.1    McKinlay, J.B.2    Krane, R.J.3
  • 3
    • 0036783940 scopus 로고    scopus 로고
    • Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses
    • Brock GB, McMahon CG, Chen KK, Costigan T, Shen W, Watkins V, Anglin G, Whitaker S (2002) Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol 168:1332-1336.
    • (2002) J Urol , vol.168 , pp. 1332-1336
    • Brock, G.B.1    McMahon, C.G.2    Chen, K.K.3    Costigan, T.4    Shen, W.5    Watkins, V.6    Anglin, G.7    Whitaker, S.8
  • 4
    • 84896844889 scopus 로고    scopus 로고
    • Evaluation and management of erectile dysfunction
    • In: Alan J, Wein MD (eds). Saunders, Philadelphia.
    • Burnett AL (2010) Evaluation and management of erectile dysfunction. In: Campbell-Walsh Urology. Alan J, Wein MD (eds). Saunders, Philadelphia, pp 732-759.
    • (2010) Campbell-Walsh Urology , pp. 732-759
    • Burnett, A.L.1
  • 5
    • 84896877762 scopus 로고    scopus 로고
    • The clinical observation on erectile dysfunction patients with type II diabetes using replenishing qi, nourishing yin and promoting blood flow herbs formula
    • Cao Y, Cao AJ, Zhang XX (2009) The clinical observation on erectile dysfunction patients with type II diabetes using replenishing qi, nourishing yin and promoting blood flow herbs formula. J Beijing Trad Chin Med 28:793-794.
    • (2009) J Beijing Trad Chin Med , vol.28 , pp. 793-794
    • Cao, Y.1    Cao, A.J.2    Zhang, X.X.3
  • 6
    • 84896820784 scopus 로고    scopus 로고
    • TCM therapeutic method of resolving phlegm and dredging collateral treating 64 erectile dysfunction patients with hyperlipidemia
    • Chen XY, Huang L, Chen WJ (2009) TCM therapeutic method of resolving phlegm and dredging collateral treating 64 erectile dysfunction patients with hyperlipidemia. J Hujian Coll Trad Chin Med 19:17-19.
    • (2009) J Hujian Coll Trad Chin Med , vol.19 , pp. 17-19
    • Chen, X.Y.1    Huang, L.2    Chen, W.J.3
  • 7
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple graphical test
    • Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple graphical test. BMJ 315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 8
    • 0028036149 scopus 로고
    • Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study
    • Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151:54-61.
    • (1994) J Urol , vol.151 , pp. 54-61
    • Feldman, H.A.1    Goldstein, I.2    Hatzichristou, D.G.3    Krane, R.J.4    McKinlay, J.B.5
  • 10
    • 84896826820 scopus 로고    scopus 로고
    • TCM therapeutic methods of tonifying kidney and soothing liver treating 64 patients with erectile dysfunction
    • Gong HM, Duan WZ, Huang XD, Li YQ (2005) TCM therapeutic methods of tonifying kidney and soothing liver treating 64 patients with erectile dysfunction. J Shandong Trad Chin Med 24:660-661.
    • (2005) J Shandong Trad Chin Med , vol.24 , pp. 660-661
    • Gong, H.M.1    Duan, W.Z.2    Huang, X.D.3    Li, Y.Q.4
  • 11
    • 0033138437 scopus 로고    scopus 로고
    • A parallel study on the effects in treatment of impotence by tonifying the kidney and improving blood circulation
    • Guo J, Kong L, Gao X, Lu J, Pang J (1999) A parallel study on the effects in treatment of impotence by tonifying the kidney and improving blood circulation. J Trad Chin Med 19:123-125.
    • (1999) J Trad Chin Med , vol.19 , pp. 123-125
    • Guo, J.1    Kong, L.2    Gao, X.3    Lu, J.4    Pang, J.5
  • 12
    • 0037378435 scopus 로고    scopus 로고
    • Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase type 5 inhibitor, in men with erectile dysfunction: results of a randomized, double-blind, 26-week placebo-controlled pivotal trial
    • Vardenafil Study Group
    • Hellstrom WJ, Gittelman M, Karlin G, Segerson T, Thibonnier M, Taylor T, Padma-Nathan H; Vardenafil Study Group (2003) Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase type 5 inhibitor, in men with erectile dysfunction: results of a randomized, double-blind, 26-week placebo-controlled pivotal trial. Urology 61:8-14.
    • (2003) Urology , vol.61 , pp. 8-14
    • Hellstrom, W.J.1    Gittelman, M.2    Karlin, G.3    Segerson, T.4    Thibonnier, M.5    Taylor, T.6    Padma-Nathan, H.7
  • 14
    • 70049099036 scopus 로고    scopus 로고
    • Chapter 8: assessing risk of bias in included studies
    • In: (updated March 2011). Higgins JPT, Green S (eds). The Cochrane Collaboration. Available at URL:
    • Higgins JPT, Altman DG, Sterne JAC (2011b) Chapter 8: assessing risk of bias in included studies. In: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). Higgins JPT, Green S (eds). The Cochrane Collaboration. Available at URL: www.cochrane-handbook.org.
    • (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • Higgins, J.P.T.1    Altman, D.G.2    Sterne, J.A.C.3
  • 15
    • 84896881431 scopus 로고    scopus 로고
    • The clinical observation on 36 patients with erectile dysfunction using resolving depression, activating blood and treating flaccidity decoction
    • Hu TC, Lu TK (2010) The clinical observation on 36 patients with erectile dysfunction using resolving depression, activating blood and treating flaccidity decoction. Bull Trad ChinMed 9:43-44.
    • (2010) Bull Trad ChinMed , vol.9 , pp. 43-44
    • Hu, T.C.1    Lu, T.K.2
  • 16
    • 84896841133 scopus 로고    scopus 로고
    • The clinical study of Tonifying kidney, dredging collaterals and sooth liver formula for treatment of erectile dysfunction
    • Hu HX, Ma JW, Zhi Y, Chen B, Ma XY (2004) The clinical study of Tonifying kidney, dredging collaterals and sooth liver formula for treatment of erectile dysfunction. J Air Force Gen Hosp 20:201-203.
    • (2004) J Air Force Gen Hosp , vol.20 , pp. 201-203
    • Hu, H.X.1    Ma, J.W.2    Zhi, Y.3    Chen, B.4    Ma, X.Y.5
  • 17
    • 39049194698 scopus 로고    scopus 로고
    • Chinese men's attitudes to life events and sexuality: prevalence of erectile dysfunction and related health concerns among Chinese men in Asian MALES study
    • Jiang H, Zhu JC (2006) Chinese men's attitudes to life events and sexuality: prevalence of erectile dysfunction and related health concerns among Chinese men in Asian MALES study. Zhonghua Nan Ke Xue 12:1048-1052.
    • (2006) Zhonghua Nan Ke Xue , vol.12 , pp. 1048-1052
    • Jiang, H.1    Zhu, J.C.2
  • 19
    • 0033964459 scopus 로고    scopus 로고
    • Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study
    • Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB (2000) Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Uro 163:460-463.
    • (2000) J Uro , vol.163 , pp. 460-463
    • Johannes, C.B.1    Araujo, A.B.2    Feldman, H.A.3    Derby, C.A.4    Kleinman, K.P.5    McKinlay, J.B.6
  • 21
    • 0033540646 scopus 로고    scopus 로고
    • Sexual dysfunction in the United States: prevalence and predictors
    • Laumann EO, Paik A, Rosen RC (1999) Sexual dysfunction in the United States: prevalence and predictors. JAMA 281:537-544.
    • (1999) JAMA , vol.281 , pp. 537-544
    • Laumann, E.O.1    Paik, A.2    Rosen, R.C.3
  • 22
    • 84857127026 scopus 로고    scopus 로고
    • The study of epidemiology of erectile dysfunction in 1582 Chinese men over 40 years old in Shanghai urban area
    • Leng J, Wang YX, Huang XY, Bo JJ, Han YF, Chen B, Dai JC, Jiang Y (2000) The study of epidemiology of erectile dysfunction in 1582 Chinese men over 40 years old in Shanghai urban area. Chin J Androl 14:29-31.
    • (2000) Chin J Androl , vol.14 , pp. 29-31
    • Leng, J.1    Wang, Y.X.2    Huang, X.Y.3    Bo, J.J.4    Han, Y.F.5    Chen, B.6    Dai, J.C.7    Jiang, Y.8
  • 23
    • 84904389193 scopus 로고    scopus 로고
    • Economic impact of urologic disease
    • In: Litwin MS, Saigal CS (eds). US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Washington, DC: US Government Printing Office; NIH Publication No. 12-7865, pp
    • Litwin MS, Saigal CS (2012) Economic impact of urologic disease. In: Urologic Diseases in America. Litwin MS, Saigal CS (eds). US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Washington, DC: US Government Printing Office; NIH Publication No. 12-7865, pp 494.
    • (2012) Urologic Diseases in America , pp. 494
    • Litwin, M.S.1    Saigal, C.S.2
  • 24
    • 0031909584 scopus 로고    scopus 로고
    • Health-related quality of life in men with erectile dysfunction
    • Litwin MS, Nied RJ, Dhanani N (1998) Health-related quality of life in men with erectile dysfunction. J Gen Intern Med 13:159-166.
    • (1998) J Gen Intern Med , vol.13 , pp. 159-166
    • Litwin, M.S.1    Nied, R.J.2    Dhanani, N.3
  • 25
    • 84896808059 scopus 로고    scopus 로고
    • Regenerating essence and assisting yang tablet treating 168 patients with erectile dysfunction
    • Liu XM (2006) Regenerating essence and assisting yang tablet treating 168 patients with erectile dysfunction. J Hun Trad Chin Med 22:19-20.
    • (2006) J Hun Trad Chin Med , vol.22 , pp. 19-20
    • Liu, X.M.1
  • 26
    • 84896869359 scopus 로고    scopus 로고
    • Relieving depression and treating flaccidity decoction treating 50 patients with psychogenic impotence
    • Lu TK, Ou'yang HG, Jin GY, Zou Q (2005) Relieving depression and treating flaccidity decoction treating 50 patients with psychogenic impotence. J Chin Med Res 28:33-34.
    • (2005) J Chin Med Res , vol.28 , pp. 33-34
    • Lu, T.K.1    Ou'yang, H.G.2    Jin, G.Y.3    Zou, Q.4
  • 27
    • 84896805137 scopus 로고    scopus 로고
    • Clinical comparative study of TCM therapeutic method of soothing liver, tonifying kidney and activating blood in treating erectile dysfunction patients with idiopathic hyperprolactinemia
    • Lu M, Wen JY, Zhu LX (2009) Clinical comparative study of TCM therapeutic method of soothing liver, tonifying kidney and activating blood in treating erectile dysfunction patients with idiopathic hyperprolactinemia. J Sichuan Trad Chin Med 5:63-64.
    • (2009) J Sichuan Trad Chin Med , vol.5 , pp. 63-64
    • Lu, M.1    Wen, J.Y.2    Zhu, L.X.3
  • 28
    • 0029910170 scopus 로고    scopus 로고
    • Clinical guidelines panel on erectile dysfunction: summary report on the treatment of organic erectile dysfunction. The American Urological Association
    • Montague DK, Barada JH, Belker AM, Levine LA, Nadig PW, Roehrborn CG, Sharlip ID, Bennett AH (1996) Clinical guidelines panel on erectile dysfunction: summary report on the treatment of organic erectile dysfunction. The American Urological Association. J Urol 156:2007-2011.
    • (1996) J Urol , vol.156 , pp. 2007-2011
    • Montague, D.K.1    Barada, J.H.2    Belker, A.M.3    Levine, L.A.4    Nadig, P.W.5    Roehrborn, C.G.6    Sharlip, I.D.7    Bennett, A.H.8
  • 31
    • 0037319256 scopus 로고    scopus 로고
    • Incidence of erectile dysfunction in men 40 to 69 years old: results from a population-based cohort study in Brazil
    • Moreira ED Jr, Lbo CF, Diament A, Nicolosi A, Glasser DB (2003) Incidence of erectile dysfunction in men 40 to 69 years old: results from a population-based cohort study in Brazil. Urology 61:431-436.
    • (2003) Urology , vol.61 , pp. 431-436
    • Moreira Jr., E.D.1    Lbo, C.F.2    Diament, A.3    Nicolosi, A.4    Glasser, D.B.5
  • 32
    • 84896896671 scopus 로고    scopus 로고
    • NCCAM The National Center for Complementary and Alternative Medicine. Traditional Chinese Medicine: An Introduction. Available at URL:
    • NCCAM (2012) The National Center for Complementary and Alternative Medicine. Traditional Chinese Medicine: An Introduction. Available at URL: http://www. nccam.nih.gov/health/whatiscam/chinesemed.htm.
    • (2012)
  • 33
    • 0027198755 scopus 로고
    • NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence
    • NIH
    • NIH (1993) NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 270:83-90.
    • (1993) JAMA , vol.270 , pp. 83-90
  • 34
    • 84896810328 scopus 로고    scopus 로고
    • R Core Team R-2.15.2 for Windows. Available at URL:
    • R Core Team (2012) R-2.15.2 for Windows. Available at URL: http://cran.r-project.org/bin/windows/base/.
    • (2012)
  • 35
    • 14544284539 scopus 로고    scopus 로고
    • Incidence rates of erectile dysfunction in the Dutch general population. Effects of definition, clinical relevance and duration of follow-up in the Krimpen Study
    • Schouten BW, Bosch JL, Bernsen RM, Blanker MH, Thomas S, Bohnen AM (2005) Incidence rates of erectile dysfunction in the Dutch general population. Effects of definition, clinical relevance and duration of follow-up in the Krimpen Study. Int J Impot Res 17:58-62.
    • (2005) Int J Impot Res , vol.17 , pp. 58-62
    • Schouten, B.W.1    Bosch, J.L.2    Bernsen, R.M.3    Blanker, M.H.4    Thomas, S.5    Bohnen, A.M.6
  • 36
    • 84896869479 scopus 로고    scopus 로고
    • SFDA Adverse Drug Reaction Bulletin. Available from URL:
    • SFDA (2012a) Adverse Drug Reaction Bulletin. Available from URL: http://www.sda.gov.cn/WS01/CL0078/.
    • (2012)
  • 37
    • 84896878260 scopus 로고    scopus 로고
    • SFDA Data Query: Domestic Drugs. Available at URL:
    • SFDA (2012b) Data Query: Domestic Drugs. Available at URL: http://www.sda.gov.cn/WS01/CL0078/.
    • (2012)
  • 38
    • 84896896775 scopus 로고    scopus 로고
    • The drug preparation and clinical study of tonifying kidney and supporting body pill
    • Sun Z (2009) The drug preparation and clinical study of tonifying kidney and supporting body pill. J Chin Trop Med 9:148-149.
    • (2009) J Chin Trop Med , vol.9 , pp. 148-149
    • Sun, Z.1
  • 39
    • 84896876618 scopus 로고    scopus 로고
    • The CONSORT Group CONSORT Statement. Available from URL:
    • The CONSORT Group (2012) CONSORT Statement. Available from URL: http://www.consort-statement.org/.
    • (2012)
  • 40
    • 79960705415 scopus 로고    scopus 로고
    • The Nordic Cochrane Centre The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen.
    • The Nordic Cochrane Centre (2011) Review Manager (RevMan) [Computer Program]. Version 5.1.7. The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen.
    • (2011) Review Manager (RevMan) [Computer Program]. Version 5.1.7
  • 41
    • 0032054651 scopus 로고    scopus 로고
    • Do certain countries produce only positive results? A systematic review of controlled trials
    • Vickers A, Goyal N, Harland R, Rees R (1998) Do certain countries produce only positive results? A systematic review of controlled trials. Control Clin Trials 19:159-166.
    • (1998) Control Clin Trials , vol.19 , pp. 159-166
    • Vickers, A.1    Goyal, N.2    Harland, R.3    Rees, R.4
  • 44
    • 84896878097 scopus 로고    scopus 로고
    • Dispelling stasis and treating flaccidity formula treating 52 patients with erectile dysfunction
    • Wang XM, Wang H (2009) Dispelling stasis and treating flaccidity formula treating 52 patients with erectile dysfunction. Herald Trad Chin Med 15:40-41.
    • (2009) Herald Trad Chin Med , vol.15 , pp. 40-41
    • Wang, X.M.1    Wang, H.2
  • 45
    • 84896854708 scopus 로고    scopus 로고
    • The clinical observation on patients with psychic impotence using Jishen oral liquid
    • Wang EJ, Liu CX, Yang L, Liu Y, Du BM (1999) The clinical observation on patients with psychic impotence using Jishen oral liquid. J Hebei Trad Chin Med 21:239-240.
    • (1999) J Hebei Trad Chin Med , vol.21 , pp. 239-240
    • Wang, E.J.1    Liu, C.X.2    Yang, L.3    Liu, Y.4    Du, B.M.5
  • 48
    • 84896829287 scopus 로고    scopus 로고
    • Influences of Shuganyiyang Capsules on expressions of NOS pathway and PDE5 in arteriogenic ED rats
    • Wang J, Wang Q, Li DH, Liu BX, Yuan ZJ (2011) Influences of Shuganyiyang Capsules on expressions of NOS pathway and PDE5 in arteriogenic ED rats. J Beijing Univ Trad Chin Med. 34:318-321.
    • (2011) J Beijing Univ Trad Chin Med. , vol.34 , pp. 318-321
    • Wang, J.1    Wang, Q.2    Li, D.H.3    Liu, B.X.4    Yuan, Z.J.5
  • 49
    • 84896818287 scopus 로고    scopus 로고
    • Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation. Available from URL:
    • Wespes E, Amar E, Eardley I, Giuliano F, Hatzichristou D, Hatzimouratidis K, Montorsi F, Vardi Y (2012) Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation. Available from URL: http://www.uroweb.org/fileadmin/guidelines/2012_Guidelines_large_text_print_total_file.
    • (2012)
    • Wespes, E.1    Amar, E.2    Eardley, I.3    Giuliano, F.4    Hatzichristou, D.5    Hatzimouratidis, K.6    Montorsi, F.7    Vardi, Y.8
  • 50
    • 84896885874 scopus 로고    scopus 로고
    • World Health Organization Why is the Registration of Clinical Trial Important? Available from URL:
    • World Health Organization (2012) Why is the Registration of Clinical Trial Important? Available from URL: http://www.who.int/ictrp/trial_reg/zh/index.html.
    • (2012)
  • 52
    • 35048864887 scopus 로고    scopus 로고
    • Consolidated standards for reporting trials of traditional Chinese medicine (CONSORT for TCM)
    • Wu TX, Li YP, Bian ZX, Li TQ, Li J, Simon D, David M (2007) Consolidated standards for reporting trials of traditional Chinese medicine (CONSORT for TCM). Chin J Evidence-Based Med 7:601-605.
    • (2007) Chin J Evidence-Based Med , vol.7 , pp. 601-605
    • Wu, T.X.1    Li, Y.P.2    Bian, Z.X.3    Li, T.Q.4    Li, J.5    Simon, D.6    David, M.7
  • 53
    • 84896879936 scopus 로고    scopus 로고
    • TCM therapeutic method of warming kidney and removing blood stasis treating 40 patients with erectile dysfunction
    • Xu HP, Hu JG (2006) TCM therapeutic method of warming kidney and removing blood stasis treating 40 patients with erectile dysfunction. J Jiangxi Trad Chin Med 37:23-24.
    • (2006) J Jiangxi Trad Chin Med , vol.37 , pp. 23-24
    • Xu, H.P.1    Hu, J.G.2
  • 55
    • 84896821743 scopus 로고    scopus 로고
    • The clinical observation on patients with erectile dysfunction of kidney deficiency syndrome ('Zheng' in Chinese pinyin) using mainly the TCM therapeutic method of nourishing Yin
    • Ying J, Xu FS (2005) The clinical observation on patients with erectile dysfunction of kidney deficiency syndrome ('Zheng' in Chinese pinyin) using mainly the TCM therapeutic method of nourishing Yin. J Shanghai Trad Chin Med 39:37-39.
    • (2005) J Shanghai Trad Chin Med , vol.39 , pp. 37-39
    • Ying, J.1    Xu, F.S.2
  • 56
    • 84896815180 scopus 로고    scopus 로고
    • TCM therapeutic method of tonifying kidney and activating blood treating 168 erectile dysfunction patients with diabetes
    • Zhang YS (2010) TCM therapeutic method of tonifying kidney and activating blood treating 168 erectile dysfunction patients with diabetes. J Guangming Trad Chin Med 12:2238-2239.
    • (2010) J Guangming Trad Chin Med , vol.12 , pp. 2238-2239
    • Zhang, Y.S.1
  • 57
    • 84896850779 scopus 로고    scopus 로고
    • The clinical observation on erectile dysfunction patients of kidney yang deficiency syndrome ('Zheng' in Chinese pinyin) using Lu-zhong warming kidney decoction
    • Zhao B, Sun YM (2011) The clinical observation on erectile dysfunction patients of kidney yang deficiency syndrome ('Zheng' in Chinese pinyin) using Lu-zhong warming kidney decoction. J Clin Res Trad Chin Med 3:52-53.
    • (2011) J Clin Res Trad Chin Med , vol.3 , pp. 52-53
    • Zhao, B.1    Sun, Y.M.2


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