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Volumn 13, Issue 3, 2014, Pages 358-370

Xenopatients 2.0 reprogrammingthe epigenetic landscapes of patient-derived cancer genomes

Author keywords

Cancer stem cells; Differentiation; Epigenetic landscape; iPS cells; Mouse avatars; Reprogramming; Stem cells; Xenografts; Yamanaka

Indexed keywords

ADULT STEM CELL; APOPTOSIS; CANCER STEM CELL; CARCINOGENESIS; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL RENEWAL; CELL SURVIVAL; CHROMOSOME ABERRATION; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; NONHUMAN; NUCLEAR REPROGRAMMING; PLASTICITY; REVIEW; RNA INTERFERENCE; TUMOR GENE; TUMOR GROWTH; ANIMAL; GENETIC EPIGENESIS; GENETICS; GENOME; HUMAN GENOME; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY; PERSONALIZED MEDICINE; PLURIPOTENT STEM CELL; TRANSLATIONAL RESEARCH; TUMOR CELL LINE;

EID: 84896838573     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.27770     Document Type: Review
Times cited : (13)

References (92)
  • 1
    • 9444263685 scopus 로고    scopus 로고
    • Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: An epigenetic mechanism of tumour progression?
    • PMID:8759617
    • Bond JA, Oddweig Ness G, Rowson J, Ivan M, White D, Wynford-Thomas D. Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: an epigenetic mechanism of tumour progression? Int J Cancer 1996; 67:563-72; PMID:8759617; http://dx.doi.org/10.1002/(SICI) 1097-0215(19960807)67:4〈563: :AID-IJC16〉3.0.CO;2-8
    • (1996) Int J Cancer , vol.67 , pp. 563-572
    • Bond, J.A.1    Oddweig Ness, G.2    Rowson, J.3    Ivan, M.4    White, D.5    Wynford-Thomas, D.6
  • 2
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • PMID:16904174
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-76; PMID:16904174; http://dx.doi.org/10.1016/j.cell.2006.07.024
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 3
    • 39149086020 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from fibroblast cultures
    • PMID:18079707
    • Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2007; 2:3081-9; PMID:18079707; http://dx.doi.org/10.1038/nprot.2007.418
    • (2007) Nat Protoc , vol.2 , pp. 3081-3089
    • Takahashi, K.1    Okita, K.2    Nakagawa, M.3    Yamanaka, S.4
  • 4
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • PMID:21386835
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med 2011; 17:313-9; PMID:21386835; http://dx.doi.org/10.1038/nm.2304
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 8
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • PMID:9212098
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3:730-7; PMID:9212098; http://dx.doi.org/10.1038/nm0797-730
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 9
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • PMID:11689955
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414:105-11; PMID:11689955; http://dx.doi.org/10. 1038/35102167
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 11
    • 0023946119 scopus 로고
    • Tumors as caricatures of the process of tissue renewal: Prospects for therapy by directing differentiation
    • PMID:2450643
    • Pierce GB, Speers WC. Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation. Cancer Res 1988; 48:1996-2004; PMID:2450643
    • (1988) Cancer Res , vol.48 , pp. 1996-2004
    • Pierce, G.B.1    Speers, W.C.2
  • 12
    • 84883845299 scopus 로고
    • Multipotentiality of single embryonal carcinoma cells
    • PMID:14234000
    • Kleinsmith LJ, Pierce GB Jr. Multipotentiality of single embryonal carcinoma cells. Cancer Res 1964; 24:1544-51; PMID:14234000
    • (1964) Cancer Res , vol.24 , pp. 1544-1551
    • Kleinsmith, L.J.1    Pierce Jr., G.B.2
  • 13
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • PMID:14504387
    • Passegué E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci USA 2003; 100(Suppl 1):11842-9; PMID:14504387; http://dx.doi.org/10.1073/pnas.2034201100
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegué, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 15
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • PMID:19878981
    • Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 2009; 139:693-706; PMID:19878981; http://dx.doi.org/10. 1016/j.cell.2009.10.014
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 16
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • PMID:21854987
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 2011; 146:633-44; PMID:21854987; http://dx.doi.org/10.1016/j.cell.2011.07.026
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 18
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • PMID:21220315
    • Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA 2011; 108:1397-402; PMID:21220315; http://dx.doi.org/10.1073/pnas.1018898108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 19
    • 84865973282 scopus 로고    scopus 로고
    • An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state
    • PMID:22908280
    • Polytarchou C, Iliopoulos D, Struhl K. An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci USA 2012; 109:14470-5; PMID:22908280; http://dx.doi.org/10.1073/pnas. 1212811109
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 14470-14475
    • Polytarchou, C.1    Iliopoulos, D.2    Struhl, K.3
  • 20
    • 80052995658 scopus 로고    scopus 로고
    • p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome
    • PMID:21779509
    • Spike BT, Wahl GM. p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer 2011; 2:404-19; PMID:21779509; http://dx.doi.org/10.1177/1947601911410224
    • (2011) Genes Cancer , vol.2 , pp. 404-419
    • Spike, B.T.1    Wahl, G.M.2
  • 21
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • PMID:19737509
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009; 138:822-9; PMID:19737509; http://dx.doi.org/10.1016/j.cell.2009.08.017
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 22
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: Impact, heterogeneity, and uncertainty
    • PMID:22439924
    • Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 2012; 21:283-96; PMID:22439924; http://dx.doi.org/10.1016/j.ccr.2012.03.003
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 23
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • PMID:24048065
    • Meacham CE, Morrison SJ. Tumour heterogeneity and cancer cell plasticity. Nature 2013; 501:328-37; PMID:24048065; http://dx.doi.org/10.1038/nature12624
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 24
    • 77953808123 scopus 로고    scopus 로고
    • Physiological cellular reprogramming and cancer
    • PMID:20188173
    • Abollo-Jiménez F, Jiménez R, Cobaleda C. Physiological cellular reprogramming and cancer. Semin Cancer Biol 2010; 20:98-106; PMID:20188173; http://dx.doi.org/10.1016/j.semcancer.2010.02.002
    • (2010) Semin Cancer Biol , vol.20 , pp. 98-106
    • Abollo-Jiménez, F.1    Jiménez, R.2    Cobaleda, C.3
  • 26
    • 77957365009 scopus 로고    scopus 로고
    • Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells
    • PMID:20841480
    • Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, et al. Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells. Cancer Res 2010; 70:7662-73; PMID:20841480; http://dx.doi.org/10.1158/0008-5472.CAN-10-1361
    • (2010) Cancer Res , vol.70 , pp. 7662-7673
    • Ohm, J.E.1    Mali, P.2    Van Neste, L.3    Berman, D.M.4    Liang, L.5    Pandiyan, K.6    Briggs, K.J.7    Zhang, W.8    Argani, P.9    Simons, B.10
  • 28
    • 84884849331 scopus 로고    scopus 로고
    • Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway
    • PMID:23974095
    • Corominas-Faja B, Cufí S, Oliveras-Ferraros C, Cuyàs E, López-Bonet E, Lupu R, Alarcón T, Vellon L, Iglesias JM, Leis O, et al. Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway. Cell Cycle 2013; 12:3109-24; PMID:23974095; http://dx.doi.org/10.4161/cc.26173
    • (2013) Cell Cycle , vol.12 , pp. 3109-3124
    • Corominas-Faja, B.1    Cufí, S.2    Oliveras-Ferraros, C.3    Cuyàs, E.4    López-Bonet, E.5    Lupu, R.6    Alarcón, T.7    Vellon, L.8    Iglesias, J.M.9    Leis, O.10
  • 30
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • PMID:23539597
    • Suvà ML, Riggi N, Bernstein BE. Epigenetic reprogramming in cancer. Science 2013; 339:1567-70; PMID:23539597; http://dx.doi.org/10.1126/ science.1230184
    • (2013) Science , vol.339 , pp. 1567-1570
    • Suvà, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 31
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • PMID:8374952
    • Kemp CJ, Donehower LA, Bradley A, Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993; 74:813-22; PMID:8374952; http://dx.doi.org/10.1016/0092-8674(93)90461-X
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 32
    • 77957733786 scopus 로고    scopus 로고
    • p53 connects tumorigenesis and reprogramming to pluripotency
    • PMID:20876313
    • Tapia N, Schöler HR. p53 connects tumorigenesis and reprogramming to pluripotency. J Exp Med 2010; 207:2045-8; PMID:20876313; http://dx.doi.org/10. 1084/jem.20101866
    • (2010) J Exp Med , vol.207 , pp. 2045-2048
    • Tapia, N.1    Schöler, H.R.2
  • 33
    • 54549095950 scopus 로고    scopus 로고
    • p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    • PMID:18948956
    • Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 2008; 455:1129-33; PMID:18948956; http://dx.doi.org/10.1038/nature07443
    • (2008) Nature , vol.455 , pp. 1129-1133
    • Zheng, H.1    Ying, H.2    Yan, H.3    Kimmelman, A.C.4    Hiller, D.J.5    Chen, A.J.6    Perry, S.R.7    Tonon, G.8    Chu, G.C.9    Ding, Z.10
  • 34
    • 77249176666 scopus 로고    scopus 로고
    • p53 and stem cells: New developments and new concerns
    • PMID:20061153
    • Zhao T, Xu Y. p53 and stem cells: new developments and new concerns. Trends Cell Biol 2010; 20:170-5; PMID:20061153; http://dx.doi.org/10.1016/j.tcb. 2009.12.004
    • (2010) Trends Cell Biol , vol.20 , pp. 170-175
    • Zhao, T.1    Xu, Y.2
  • 36
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • PMID:21075313
    • Quintana E, Shackleton M, Foster HR, Fullen DR, Sabel MS, Johnson TM, Morrison SJ. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010; 18:510-23; PMID:21075313; http://dx.doi.org/10.1016/j.ccr.2010.10.012
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3    Fullen, D.R.4    Sabel, M.S.5    Johnson, T.M.6    Morrison, S.J.7
  • 37
    • 77953163539 scopus 로고    scopus 로고
    • CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer
    • PMID:20484027
    • Meyer MJ, Fleming JM, Lin AF, Hussnain SA, Ginsburg E, Vonderhaar BK. CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res 2010; 70:4624-33; PMID:20484027; http://dx.doi.org/10.1158/0008-5472.CAN-09-3619
    • (2010) Cancer Res , vol.70 , pp. 4624-4633
    • Meyer, M.J.1    Fleming, J.M.2    Lin, A.F.3    Hussnain, S.A.4    Ginsburg, E.5    Vonderhaar, B.K.6
  • 38
    • 46149089421 scopus 로고    scopus 로고
    • Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression
    • PMID:18614011
    • Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, Liu A, Miu K, Watnick RS, Reinhardt F, et al. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell 2008; 134:62-73; PMID:18614011; http://dx.doi.org/10.1016/j.cell.2008.06.006
    • (2008) Cell , vol.134 , pp. 62-73
    • Godar, S.1    Ince, T.A.2    Bell, G.W.3    Feldser, D.4    Donaher, J.L.5    Bergh, J.6    Liu, A.7    Miu, K.8    Watnick, R.S.9    Reinhardt, F.10
  • 39
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • PMID:21240262
    • Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011; 17:211-5; PMID:21240262; http://dx.doi.org/10.1038/nm.2284
    • (2011) Nat Med , vol.17 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3    Chen, X.4    Calhoun-Davis, T.5    Li, H.6    Patrawala, L.7    Yan, H.8    Jeter, C.9    Honorio, S.10
  • 42
    • 70450193138 scopus 로고    scopus 로고
    • A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells
    • PMID:19890402
    • Hough SR, Laslett AL, Grimmond SB, Kolle G, Pera MF. A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells. PLoS One 2009; 4:e7708; PMID:19890402; http://dx.doi.org/10.1371/journal.pone. 0007708
    • (2009) PLoS One , vol.4
    • Hough, S.R.1    Laslett, A.L.2    Grimmond, S.B.3    Kolle, G.4    Pera, M.F.5
  • 43
    • 84878273239 scopus 로고    scopus 로고
    • Induction of pluripotency in mouse somatic cells with lineage specifiers
    • PMID:23706735
    • Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, et al. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 2013; 153:963-75; PMID:23706735; http://dx.doi.org/10.1016/j.cell.2013.05. 001
    • (2013) Cell , vol.153 , pp. 963-975
    • Shu, J.1    Wu, C.2    Wu, Y.3    Li, Z.4    Shao, S.5    Zhao, W.6    Tang, X.7    Yang, H.8    Shen, L.9    Zuo, X.10
  • 46
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • PMID:19668191
    • Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460:1132-5; PMID:19668191; http://dx.doi.org/10. 1038/nature08235
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1    Takahashi, K.2    Ichisaka, T.3    Aoi, T.4    Kanagawa, O.5    Nakagawa, M.6    Okita, K.7    Yamanaka, S.8
  • 48
  • 50
    • 77957748239 scopus 로고    scopus 로고
    • Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells
    • PMID:20696700
    • Sarig R, Rivlin N, Brosh R, Bornstein C, Kamer I, Ezra O, Molchadsky A, Goldfinger N, Brenner O, Rotter V. Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells. J Exp Med 2010; 207:2127-40; PMID:20696700; http://dx.doi.org/10.1084/jem.20100797
    • (2010) J Exp Med , vol.207 , pp. 2127-2140
    • Sarig, R.1    Rivlin, N.2    Brosh, R.3    Bornstein, C.4    Kamer, I.5    Ezra, O.6    Molchadsky, A.7    Goldfinger, N.8    Brenner, O.9    Rotter, V.10
  • 51
    • 34147113900 scopus 로고    scopus 로고
    • A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas
    • PMID:17204602
    • Assou S, Le Carrour T, Tondeur S, Ström S, Gabelle A, Marty S, Nadal L, Pantesco V, Réme T, Hugnot JP, et al. A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells 2007; 25:961-73; PMID:17204602; http://dx.doi.org/10.1634/stemcells. 2006-0352
    • (2007) Stem Cells , vol.25 , pp. 961-973
    • Assou, S.1    Le Carrour, T.2    Tondeur, S.3    Ström, S.4    Gabelle, A.5    Marty, S.6    Nadal, L.7    Pantesco, V.8    Réme, T.9    Hugnot, J.P.10
  • 52
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • PMID:18443585
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40:499-507; PMID:18443585; http://dx.doi.org/10.1038/ng.127
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 53
    • 77957757417 scopus 로고    scopus 로고
    • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
    • PMID:20946988
    • Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010; 143:313-24; PMID:20946988; http://dx.doi.org/10.1016/j.cell.2010.09.010
    • (2010) Cell , vol.143 , pp. 313-324
    • Kim, J.1    Woo, A.J.2    Chu, J.3    Snow, J.W.4    Fujiwara, Y.5    Kim, C.G.6    Cantor, A.B.7    Orkin, S.H.8
  • 54
    • 41449118521 scopus 로고    scopus 로고
    • Module map of stem cell genes guides creation of epithelial cancer stem cells
    • PMID:18397753
    • Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008; 2:333-44; PMID:18397753; http://dx.doi.org/10.1016/j.stem.2008.02.009
    • (2008) Cell Stem Cell , vol.2 , pp. 333-344
    • Wong, D.J.1    Liu, H.2    Ridky, T.W.3    Cassarino, D.4    Segal, E.5    Chang, H.Y.6
  • 55
    • 78651100119 scopus 로고    scopus 로고
    • Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
    • PMID:21149740
    • Mizuno H, Spike BT, Wahl GM, Levine AJ. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci USA 2010; 107:22745-50; PMID:21149740; http://dx.doi.org/10.1073/pnas. 1017001108
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 22745-22750
    • Mizuno, H.1    Spike, B.T.2    Wahl, G.M.3    Levine, A.J.4
  • 57
    • 42349093818 scopus 로고    scopus 로고
    • Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer
    • PMID:18413752
    • Jimeno A, Tan AC, Coffa J, Rajeshkumar NV, Kulesza P, Rubio-Viqueira B, Wheelhouse J, Diosdado B, Messersmith WA, Iacobuzio-Donahue C, et al. Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer. Cancer Res 2008; 68:2841-9; PMID:18413752; http://dx.doi.org/10.1158/ 0008-5472.CAN-07-5200
    • (2008) Cancer Res , vol.68 , pp. 2841-2849
    • Jimeno, A.1    Tan, A.C.2    Coffa, J.3    Rajeshkumar, N.V.4    Kulesza, P.5    Rubio-Viqueira, B.6    Wheelhouse, J.7    Diosdado, B.8    Messersmith, W.A.9    Iacobuzio-Donahue, C.10
  • 59
    • 84883194174 scopus 로고    scopus 로고
    • Primary human non-small cell lung and pancreatic tumorgraft models-utility and applications in drug discovery and tumor biology
    • Chapter 14:Unit 14.26
    • Calles A, Rubio-Viqueira B, Hidalgo M. Primary human non-small cell lung and pancreatic tumorgraft models-utility and applications in drug discovery and tumor biology. Curr Protoc Pharmacol 2013;Chapter 14:Unit 14.26.
    • (2013) Curr Protoc Pharmacol
    • Calles, A.1    Rubio-Viqueira, B.2    Hidalgo, M.3
  • 60
    • 84862772839 scopus 로고    scopus 로고
    • A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
    • PMID:22586653
    • Bertotti A, Migliardi G, Galimi F, Sassi F, Torti D, Isella C, Corà D, Di Nicolantonio F, Buscarino M, Petti C, et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov 2011; 1:508-23; PMID:22586653; http://dx.doi.org/10.1158/2159-8290.CD-11-0109
    • (2011) Cancer Discov , vol.1 , pp. 508-523
    • Bertotti, A.1    Migliardi, G.2    Galimi, F.3    Sassi, F.4    Torti, D.5    Isella, C.6    Corà, D.7    Di Nicolantonio, F.8    Buscarino, M.9    Petti, C.10
  • 62
    • 0029774144 scopus 로고    scopus 로고
    • Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice
    • PMID:8971180
    • Reyes G, Villanueva A, García C, Sancho FJ, Piulats J, Lluís F, Capellá G. Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. Cancer Res 1996; 56:5713-9; PMID:8971180
    • (1996) Cancer Res , vol.56 , pp. 5713-5719
    • Reyes, G.1    Villanueva, A.2    García, C.3    Sancho, F.J.4    Piulats, J.5    Lluís, F.6    Capellá, G.7
  • 63
    • 66149168686 scopus 로고    scopus 로고
    • Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors
    • PMID:19417025
    • Castillo-Avila W, Piulats JM, Garcia Del Muro X, Vidal A, Condom E, Casanovas O, Mora J, Germà JR, Capellà G, Villanueva A, et al. Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. Clin Cancer Res 2009; 15:3384-95; PMID:19417025; http://dx.doi.org/10. 1158/1078-0432.CCR-08-2170
    • (2009) Clin Cancer Res , vol.15 , pp. 3384-3395
    • Castillo-Avila, W.1    Piulats, J.M.2    Garcia Del Muro, X.3    Vidal, A.4    Condom, E.5    Casanovas, O.6    Mora, J.7    Germà, J.R.8    Capellà, G.9    Villanueva, A.10
  • 65
    • 84875750487 scopus 로고    scopus 로고
    • The scientific drunk and the lamppost: Massive sequencing efforts in cancer discovery and treatment
    • PMID:23550209
    • Yaffe MB. The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment. Sci Signal 2013; 6:pe13; PMID:23550209; http://dx.doi.org/10.1126/scisignal.2003684
    • (2013) Sci Signal , vol.6
    • Yaffe, M.B.1
  • 66
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: A roadmap to safe regenerative medicine
    • PMID:19415771
    • Knoepfler PS. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 2009; 27:1050-6; PMID:19415771; http://dx.doi.org/10.1002/stem.37
    • (2009) Stem Cells , vol.27 , pp. 1050-1056
    • Knoepfler, P.S.1
  • 68
    • 84880026566 scopus 로고    scopus 로고
    • Genome editing of human pluripotent stem cells to generate human cellular disease models
    • PMID:23751357
    • Musunuru K. Genome editing of human pluripotent stem cells to generate human cellular disease models. Dis Model Mech 2013; 6:896-904; PMID:23751357; http://dx.doi.org/10.1242/dmm.012054
    • (2013) Dis Model Mech , vol.6 , pp. 896-904
    • Musunuru, K.1
  • 70
    • 79952697048 scopus 로고    scopus 로고
    • Targeted genome editing in pluripotent stem cells using zinc-finger nucleases
    • PMID:21185378
    • Bobis-Wozowicz S, Osiak A, Rahman SH, Cathomen T. Targeted genome editing in pluripotent stem cells using zinc-finger nucleases. Methods 2011; 53:339-46; PMID:21185378; http://dx.doi.org/10.1016/j.ymeth.2010.12.019
    • (2011) Methods , vol.53 , pp. 339-346
    • Bobis-Wozowicz, S.1    Osiak, A.2    Rahman, S.H.3    Cathomen, T.4
  • 71
    • 84889811646 scopus 로고    scopus 로고
    • Role of stem cells in large animal genetic engineering in the TALENs-CRISPR era
    • PMID:24305178
    • Park KE, Telugu BP. Role of stem cells in large animal genetic engineering in the TALENs-CRISPR era. Reprod Fertil Dev 2013; 26:65-73; PMID:24305178; http://dx.doi.org/10.1071/RD13258
    • (2013) Reprod Fertil Dev , vol.26 , pp. 65-73
    • Park, K.E.1    Telugu, B.P.2
  • 72
    • 38349035679 scopus 로고    scopus 로고
    • Specific clones of spontaneously evolving karyotypes generate individuality of cancers
    • PMID:18206533
    • Fabarius A, Li R, Yerganian G, Hehlmann R, Duesberg P. Specific clones of spontaneously evolving karyotypes generate individuality of cancers. Cancer Genet Cytogenet 2008; 180:89-99; PMID:18206533; http://dx.doi.org/10.1016/j. cancergencyto.2007.10.006
    • (2008) Cancer Genet Cytogenet , vol.180 , pp. 89-99
    • Fabarius, A.1    Li, R.2    Yerganian, G.3    Hehlmann, R.4    Duesberg, P.5
  • 73
  • 74
    • 70349195036 scopus 로고    scopus 로고
    • On the karyotypic origin and evolution of cancer cells
    • PMID:19781442
    • Nicholson JM, Duesberg P. On the karyotypic origin and evolution of cancer cells. Cancer Genet Cytogenet 2009; 194:96-110; PMID:19781442; http://dx.doi.org/10.1016/j.cancergencyto.2009.06.008
    • (2009) Cancer Genet Cytogenet , vol.194 , pp. 96-110
    • Nicholson, J.M.1    Duesberg, P.2
  • 75
    • 79951689086 scopus 로고    scopus 로고
    • Identification of aneuploidy-selective antiproliferation compounds
    • PMID:21315436
    • Tang YC, Williams BR, Siegel JJ, Amon A. Identification of aneuploidy-selective antiproliferation compounds. Cell 2011; 144:499-512; PMID:21315436; http://dx.doi.org/10.1016/j.cell.2011.01.017
    • (2011) Cell , vol.144 , pp. 499-512
    • Tang, Y.C.1    Williams, B.R.2    Siegel, J.J.3    Amon, A.4
  • 76
    • 79951698074 scopus 로고    scopus 로고
    • Targeting aneuploidy for cancer therapy
    • PMID:21335229
    • Manchado E, Malumbres M. Targeting aneuploidy for cancer therapy. Cell 2011; 144:465-6; PMID:21335229; http://dx.doi.org/10.1016/j.cell.2011.01.037
    • (2011) Cell , vol.144 , pp. 465-466
    • Manchado, E.1    Malumbres, M.2
  • 77
    • 84861853732 scopus 로고    scopus 로고
    • Losing balance: The origin and impact of aneuploidy in cancer
    • PMID:22565320
    • Holland AJ, Cleveland DW. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep 2012; 13:501-14; PMID:22565320; http://dx.doi.org/10.1038/embor.2012.55
    • (2012) EMBO Rep , vol.13 , pp. 501-514
    • Holland, A.J.1    Cleveland, D.W.2
  • 78
    • 84861880210 scopus 로고    scopus 로고
    • Chromosomal instability and aneuploidy in cancer: From yeast to man
    • PMID:22614003
    • Pfau SJ, Amon A. Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep 2012; 13:515-27; PMID:22614003; http://dx.doi.org/10. 1038/embor.2012.65
    • (2012) EMBO Rep , vol.13 , pp. 515-527
    • Pfau, S.J.1    Amon, A.2
  • 81
    • 84877574727 scopus 로고    scopus 로고
    • Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming
    • 2260.e1-21: PMID:22777357
    • Zhang X, Cruz FD, Terry M, Remotti F, Matushansky I. Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming. Oncogene 2013; 32(2260.e1-21):2249-60, e1-21; PMID:22777357; http://dx.doi.org/10.1038/onc.2012.237
    • (2013) Oncogene , vol.32
    • Zhang, X.1    Cruz, F.D.2    Terry, M.3    Remotti, F.4    Matushansky, I.5
  • 82
    • 84877584763 scopus 로고    scopus 로고
    • Reprogramming cancer cells: Back to the future
    • PMID:22869153
    • Lang JY, Shi Y, Chin YE. Reprogramming cancer cells: back to the future. Oncogene 2013; 32:2247-8; PMID:22869153; http://dx.doi.org/10.1038/onc.2012.349
    • (2013) Oncogene , vol.32 , pp. 2247-2248
    • Lang, J.Y.1    Shi, Y.2    Chin, Y.E.3
  • 83
    • 84879798872 scopus 로고    scopus 로고
    • An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
    • PMID:23791528
    • Kim J, Hoffman JP, Alpaugh RK, Rhim AD, Reichert M, Stanger BZ, Furth EE, Sepulveda AR, Yuan CX, Won KJ, et al. An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep 2013; 3:2088-99; PMID:23791528; http://dx.doi.org/10.1016/ j.celrep.2013.05.036
    • (2013) Cell Rep , vol.3 , pp. 2088-2099
    • Kim, J.1    Hoffman, J.P.2    Alpaugh, R.K.3    Rhim, A.D.4    Reichert, M.5    Stanger, B.Z.6    Furth, E.E.7    Sepulveda, A.R.8    Yuan, C.X.9    Won, K.J.10
  • 84
    • 84860517655 scopus 로고    scopus 로고
    • iPSCs from cancer cells: Challenges and opportunities
    • PMID:22521522
    • Ramos-Mejia V, Fraga MF, Menendez P. iPSCs from cancer cells: challenges and opportunities. Trends Mol Med 2012; 18:245-7; PMID:22521522; http://dx.doi.org/10.1016/j.molmed.2012.04.001
    • (2012) Trends Mol Med , vol.18 , pp. 245-247
    • Ramos-Mejia, V.1    Fraga, M.F.2    Menendez, P.3
  • 86
    • 78149487692 scopus 로고    scopus 로고
    • Pluripotency and cellular reprogramming: Facts, hypotheses, unresolved issues
    • PMID:21074044
    • Hanna JH, Saha K, Jaenisch R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 2010; 143:508-25; PMID:21074044; http://dx.doi.org/10.1016/j.cell.2010.10.008
    • (2010) Cell , vol.143 , pp. 508-525
    • Hanna, J.H.1    Saha, K.2    Jaenisch, R.3
  • 87
    • 82555169760 scopus 로고    scopus 로고
    • Gene expression heterogeneities in embryonic stem cell populations: Origin and function
    • PMID:21982544
    • Martinez Arias A, Brickman JM. Gene expression heterogeneities in embryonic stem cell populations: origin and function. Curr Opin Cell Biol 2011; 23:650-6; PMID:21982544; http://dx.doi.org/10.1016/j.ceb.2011.09.007
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 650-656
    • Martinez Arias, A.1    Brickman, J.M.2
  • 88
    • 66449090934 scopus 로고    scopus 로고
    • Reprogramming cell fates: Reconciling rarity with robustness
    • PMID:19319911
    • Huang S. Reprogramming cell fates: reconciling rarity with robustness. Bioessays 2009; 31:546-60; PMID:19319911; http://dx.doi.org/10.1002/bies. 200800189
    • (2009) Bioessays , vol.31 , pp. 546-560
    • Huang, S.1
  • 89
    • 77649208749 scopus 로고    scopus 로고
    • Cancer stem cells: A reality, a myth, a fuzzy concept or a misnomer? An analysis
    • PMID:19858069
    • Maenhaut C, Dumont JE, Roger PP, van Staveren WC. Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis. Carcinogenesis 2010; 31:149-58; PMID:19858069; http://dx.doi.org/10.1093/carcin/bgp259
    • (2010) Carcinogenesis , vol.31 , pp. 149-158
    • Maenhaut, C.1    Dumont, J.E.2    Roger, P.P.3    Van Staveren, W.C.4
  • 90
    • 84865589453 scopus 로고    scopus 로고
    • Hallmarks of cancer: Of all cancer cells, all the time?
    • PMID:22795735
    • Floor SL, Dumont JE, Maenhaut C, Raspe E. Hallmarks of cancer: of all cancer cells, all the time? Trends Mol Med 2012; 18:509-15; PMID:22795735; http://dx.doi.org/10.1016/j.molmed.2012.06.005
    • (2012) Trends Mol Med , vol.18 , pp. 509-515
    • Floor, S.L.1    Dumont, J.E.2    Maenhaut, C.3    Raspe, E.4
  • 91
    • 84863035821 scopus 로고    scopus 로고
    • Cancer stem cells: Distinct entities or dynamically regulated phenotypes?
    • PMID:22298594
    • Li Y, Laterra J. Cancer stem cells: distinct entities or dynamically regulated phenotypes? Cancer Res 2012; 72:576-80; PMID:22298594; http://dx.doi.org/10.1158/0008-5472.CAN-11-3070
    • (2012) Cancer Res , vol.72 , pp. 576-580
    • Li, Y.1    Laterra, J.2
  • 92
    • 84891867110 scopus 로고    scopus 로고
    • Cancer stem cells, a fuzzy evolving concept: A cell population or a cell property?
    • Epub ahead of print PMID:24270846
    • Antoniou A, Hébrant A, Dom G, Dumont JE, Maenhaut C. Cancer stem cells, a fuzzy evolving concept: A cell population or a cell property? [Epub ahead of print]. Cell Cycle 2013; 12:3743-8; PMID:24270846; http://dx.doi.org/ 10.4161/cc.27305
    • (2013) Cell Cycle , vol.12 , pp. 3743-3748
    • Antoniou, A.1    Hébrant, A.2    Dom, G.3    Dumont, J.E.4    Maenhaut, C.5


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