TIGAR's promiscuity

Biochemical Journal

Volumn 458, Issue 3, 2014, Pages

  Bolaños, Juan P ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

2,3 bisphosphoglycerate phosphatase; Cancer; Glycolysis; Haemoglobin; Hypoxia; Mitochondrion; Oxygen sensing

Indexed keywords

FRUCTOSE 2,6 BISPHOSPHATASE; FRUCTOSE 2,6 BISPHOSPHATE; PROTEIN; PROTEIN P53; PROTEIN TIGAR; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; CANCER CELL; CELL METABOLISM; CELL PROTECTION; DEPHOSPHORYLATION; ENZYME ACTIVITY; GLUCONEOGENESIS; GLUCOSE INTAKE; GLYCOLYSIS; HUMAN; METABOLIC REGULATION; NONHUMAN; NOTE; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

ANIMALS; GLYCOLATES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHORIC MONOESTER HYDROLASES;

EID: 84896830899     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140087     Document Type: Note

References (14)

1. Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N., Nakano, K., Bartrons, R., Gottlieb, E. and Vousden, K. H. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120 (Pubitemid 44040989)
2. Van Schaftingen, E., Lederer, B., Bartrons, R. and Hers, H. G. (1982) A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur. J. Biochem. 129, 191-195
3. Bensaad, K., Cheung, E. C. and Vousden, K. H. (2009) Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J. 28, 3015-3026
4. Sakakibara, R., Uemura, M., Hirata, T., Okamura, N. and Kato, M. (1997) Human placental fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase: its isozymic form, expression and characterization. Biosci. Biotechnol. Biochem. 61, 1949-1952 (Pubitemid 127471802)
5. Herrero-Mendez, A., Almeida, A., Fernandez, E., Maestre, C., Moncada, S. and Bolanos, J. P. (2009) The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat. Cell Biol. 11, 747-752
6. Li, H. and Jogl, G. (2009) Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). J. Biol. Chem. 284, 1748-1754
7. Gerin, I., Noël, G., Bolsée, J., Haumont, O., Van Schaftingen, E. and Bommer, G. T. (2014) Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase. Biochem J. 458, 439-448
8. Rigden, D. J. (2008) The histidine phosphatase superfamily: structure and function. Biochem. J. 409, 333-348
9. Carreras, J., Bartrons, R., Bosch, J. and Pons, G. (1981) Metabolism of glycerate-2,3-P2-I. Distribution of the enzymes involved in the glycerate-2,3-P2 metabolism in pig tissues. Comp. Biochem. Physiol. B. 70B, 477-485 (Pubitemid 12221803)
10. Vander Heiden, M. G., Locasale, J. W., Swanson, K. D., Sharfi, H., Heffron, G. J., Amador-Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J. D., Asara, J. M. and Cantley, L. C. (2010) Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 329, 1492-1499
11. Benesch, B. and Benesch, R. E. (1967) The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. Biochem. Biophys. Res. Commun. 26, 162-167
12. Biagioli, M., Pinto, M., Cesselli, D., Zaninello, M., Lazarevic, D., Roncaglia, P., Simone, R., Vlachouli, C., Plessy, C., Bertin, N. et al. (2009) Unexpected expression of α- and β-globin in mesencephalic dopaminergic neurons and glial cells. Proc. Natl. Acad. Sci. U.S.A. 106, 15454-15459
13. Emara, M., Turner, A. R. and Allalunis-Turner, J. (2014) Adult, embryonic and fetal hemoglobin are expressed in human glioblastoma cells. Int. J. Oncol. 44, 514-520
14. Cheung, E. C., Ludwig, R. L. and Vousden, K. H. (2012) Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc. Natl. Acad. Sci. U.S.A. 109, 20491-20496