In vitro evaluation of Panax notoginseng Rg1 released from collagen/chitosan-gelatin microsphere scaffolds for angiogenesis

BioMedical Engineering Online

Volumn 12, Issue 1, 2013, Pages

  Zheng, Yurong ^a   Feng, Zhanzeng ^a   You, Chuangang ^a   Jin, Yunyun ^a   Hu, Xinlei ^a   Wang, Xingang ^a   Han, Chunmao ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Angiogenesis; Controlled release; Gelatin microsphere; Panax notoginseng saponins; Vascular endothelial growth factor (VEGF)

Indexed keywords

BIOCOMPATIBILITY; CELL DEATH; CELL ENGINEERING; ENDOTHELIAL CELLS; MICROSPHERES; PHYSIOLOGY; REPAIR; TUBES (COMPONENTS);

ANGIOGENESIS; CONTROLLED RELEASE; GELATIN MICROSPHERES; PANAX NOTOGINSENG; VASCULAR ENDOTHELIAL GROWTH FACTOR;

SCAFFOLDS (BIOLOGY);

CHITOSAN; COLLAGEN; GELATIN; GINSENOSIDE RG 1; MICROSPHERE; VASCULOTROPIN; DRUG CARRIER; GINSENOSIDE; VASCULOTROPIN A;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; KINETICS; PANAX NOTOGINSENG; PROTEIN SECRETION; UMBILICAL VEIN ENDOTHELIAL CELL; CELL CYCLE; CELL MOTION; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM;

APOPTOSIS; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CHITOSAN; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; GELATIN; GENE EXPRESSION REGULATION; GINSENOSIDES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KINETICS; MICROSPHERES; NEOVASCULARIZATION, PHYSIOLOGIC; PANAX NOTOGINSENG; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84896821322     PISSN: None     EISSN: 1475925X     Source Type: Journal    
DOI: 10.1186/1475-925X-12-134     Document Type: Article

References (29)

1. MacNeil S. Progress and opportunities for tissue-engineered skin. Nature 2007, 445(7130):874-880. 10.1038/nature05664, 17314974.
2. Ma L, Gao C, Mao Z, Zhou J, Shen J, Hu X, Han C. Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials 2003, 24(26):4833-4841. 10.1016/S0142-9612(03)00374-0, 14530080.
3. Hutmacher DW. Scaffold design and fabrication technologies for engineering tissues-state of the art and future perspectives. J Biomater Sci Polym Ed 2001, 12(1):107-124. 10.1163/156856201744489, 11334185.
4. Haifei S, Xingang W, Shoucheng W, Zhengwei M, Chuangang Y, Chunmao H. The effect of collagen-chitosan porous scaffold thickness on dermal regeneration in a one-stage grafting procedure. J Mech Behav Biomed Mater 2014, 29:114-125.
5. Chung JY, Kowal-Vern A, Latenser BA, Lewis RW. Cement-related injuries: review of a series, the National Burn Repository, and the prevailing literature. J Burn Care Res 2007, 28(6):827-834. 10.1097/BCR.0b013e3181599bb1, 17925652.
6. Patel ZS, Mikos AG. Angiogenesis with biomaterial-based drug-and cell-delivery systems. J Biomater Sci Polym Ed 2004, 15(6):701-726. 10.1163/156856204774196117, 15255521.
7. Young S, Wong M, Tabata Y, Mikos AG. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 2005, 109(1):256-274.
8. Bowen-Pope DF, Malpass TW, Foster DM, Ross R. Platelet-derived growth factor in vivo: levels, activity, and rate of clearance. Blood 1984, 64(2):458-469.
9. Ling C, Li Y, Zhu X, Zhang C, Li M. Ginsenosides may reverse the dexamethasone-induced down-regulation of glucocorticoid receptor. Gen Comp Endocrinol 2005, 140(3):203-209. 10.1016/j.ygcen.2004.11.003, 15639148.
10. Chan RY, Chen W-F, Dong A, Guo D, Wong M-S. Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab 2002, 87(8):3691-3695. 10.1210/jcem.87.8.8717, 12161497.
11. Morales DE, McGowan KA, Grant DS, Maheshwari S, Bhartiya D, Cid MC, Kleinman HK, Schnaper HW. Estrogen promotes angiogenic activity in human umbilical vein endothelial cells in vitro and in a murine model. Circulation 1995, 91(3):755-763. 10.1161/01.CIR.91.3.755, 7530174.
12. Yang N, Chen P, Tao Z, Zhou N, Gong X, Xu Z, Zhang M, Zhang D, Chen B, Tao Z. Beneficial effects of ginsenoside-Rg1 on ischemia-induced angiogenesis in diabetic mice. Acta Biochim Biophys Sin (Shanghai) 2012, 44(12):999-1005. 10.1093/abbs/gms092, 23111241.
13. Shi A, Gu N, Liu X, Wang X, Peng Y. Ginsenoside rg1 enhances endothelial progenitor cell angiogenic potency and prevents senescence in vitro. J Int Med Res 2011, 39(4):1306-1318. 10.1177/147323001103900418, 21986132.
14. Hiraoka Y, Yamashiro H, Yasuda K, Kimura Y, Inamoto T, Tabata Y. In situ regeneration of adipose tissue in rat fat pad by combining a collagen scaffold with gelatin microspheres containing basic fibroblast growth factor. Tissue Eng 2006, 12(6):1475-1487. 10.1089/ten.2006.12.1475, 16846345.
15. Shi H, Han C, Mao Z, Ma L, Gao C. Enhanced angiogenesis in porous collagen-chitosan scaffolds loaded with angiogenin. Tissue Eng Part A 2008, 14(11):1775-1785. 10.1089/ten.tea.2007.0007, 18950270.
16. Wu CC, Chen WH, Zao B, Lai PL, Lin TC, Lo HY, Shieh YH, Wu CH, Deng WP. Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis. Biomaterials 2011, 32(25):5847-5854. 10.1016/j.biomaterials.2011.05.002, 21616530.
17. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004, 25(4):581-611. 10.1210/er.2003-0027, 15294883.
18. Gerber H, McMurtrey A, Kowalski J, Yan M, Keyt B, Dixit V, Ferrara N. VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 1998, 273(30)):336-343.
19. Tran J, Master Z, Joanne LY, Rak J, Dumont DJ, Kerbel RS. A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci 2002, 99(7):4349-4354. 10.1073/pnas.072586399, 123651, 11917134.
20. Gerber H-P, Dixit V, Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 1998, 273(21):13313-13316. 10.1074/jbc.273.21.13313, 9582377.
21. Leung KW, Cheng Y-K, Mak NK, Chan KK, David Fan T, Wong RN. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett 2006, 580(13):3211-3216. 10.1016/j.febslet.2006.04.080, 16696977.
22. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K, Aird WC. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol 2004, 24(2):294-300. 10.1161/01.ATV.0000110502.10593.06, 14656735.
23. A-w S, Wang X-b L, F-x ZM-M, X-q K, K-j C. Ginsenoside Rg1 promotes endothelial progenitor cell migration and proliferation. Acta Pharmacol Sin 2009, 30(3):299-306. 10.1038/aps.2009.6, 19262553.
24. Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell cycle 2003, 2(4):336-342.
25. Leung KW, Pon YL, Wong RN, Wong AS. Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β-catenin/T-cell factor-dependent pathway in human endothelial cells. J Biol Chem 2006, 281(47):36280-36288. 10.1074/jbc.M606698200, 17008323.
26. Iwanaga K, Yabuta T, Kakemi M, Morimoto K, Tabata Y, Ikada Y. Usefulness of microspheres composed of gelatin with various cross-linking density. J Microencapsul 2003, 20(6):767-776. 10.1080/02652040310001600523, 14594665.
27. Park YJ, Lee YM, Lee JY, Seol YJ, Chung CP, Lee SJ. Controlled release of platelet-derived growth factor-BB from chondroitin sulfate-chitosan sponge for guided bone regeneration. J Control Release 2000, 67(2):385-394.
28. Popovich DG, Kitts DD. Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch Biochem Biophys 2002, 406(1):1-8. 10.1016/S0003-9861(02)00398-3, 12234484.
29. Tongay S, Dag S, Durgun E, Senger R, Ciraci S. Atomic and electronic structure of carbon strings. J Phys Condens Matter 2005, 17(25):3823-3837. 10.1088/0953-8984/17/25/009, 21690699.