Changes in copper concentrations affect the protein levels but not the mRNA levels of copper chaperones in human umbilical vein endothelial cells

Metallomics

Volumn 6, Issue 3, 2014, Pages 554-559

  Dong, Daoyin ^a   Xu, Xinhua ^a   Yin, Wen ^a   Kang, Y James ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC ABSORPTION SPECTROPHOTOMETER; COPPER CONCENTRATION; CYTOCHROME C OXIDASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; POST-TRANSLATIONAL MODIFICATIONS; SUPER OXIDE DISMUTASE; TETRAETHYLENEPENTAMINE; WESTERN-BLOT ANALYSIS;

ENDOTHELIAL CELLS; OXYGEN; PROTEINS;

COPPER;

ATOX 1 PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; CHAPERONE; COPPER; COPPER CHAPERONE; COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE 1; COPPER SULFIDE; COPPER TRANSPORTER 1; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C OXIDASE; MESSENGER RNA; SMALL INTERFERING RNA; SULFIDE; TEPA; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CELL LEVEL; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECTROPHOTOMETER; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

CARRIER PROTEINS; CATION TRANSPORT PROTEINS; COPPER; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MOLECULAR CHAPERONES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84896818142     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c3mt00138e     Document Type: Article

References (20)

1. B. E. Kim T. Nevitt D. J. Thiele Mechanisms for Copper Acquisition, Distribution and Regulation Nat. Chem. Biol. 2008 4 176 185
2. J. F. Mercer The Molecular Basis of Copper-Transport Diseases Trends Mol. Med. 2001 7 64 69
3. P. A. Adlard A. I. Bush Metals and Alzheimer's Disease J. Alzheimer's Dis. 2006 10 145 163
4. Bharathi S. S. Indi K. S. Rao Copper- and Iron-Induced Differential Fibril Formation in Alpha-Synuclein: Tem Study Neurosci. Lett. 2007 424 78 82
5. 2+ Coordination by His96 and His111 Induces Beta-Sheet Formation in the Unstructured Amyloidogenic Region of the Prion Protein J. Biol. Chem. 2004 279 32018 32027
6. Q. Pan C. G. Kleer K. L. van Golen J. Irani K. M. Bottema C. Bias M. De Carvalho E. A. Mesri D. M. Robins R. D. Dick G. J. Brewer S. D. Merajver Copper Deficiency Induced by Tetrathiomolybdate Suppresses Tumor Growth and Angiogenesis Cancer Res. 2002 62 4854 4859
7. Y. J. Kang Copper and Homocysteine in Cardiovascular Diseases Pharmacol. Ther. 2011 129 321 331
8. T. D. Rae P. J. Schmidt R. A. Pufahl V. C. Culotta T. V. O'Halloran Undetectable Intracellular Free Copper: The Requirement of a Copper Chaperone for Superoxide Dismutase Science 1999 284 805 808
9. J. Bertinato M. Iskandar M. R. L'Abbe Copper Deficiency Induces the Upregulation of the Copper Chaperone for Cu/Zn Superoxide Dismutase in Weanling Male Rats J. Nutr. 2003 133 28 31
10. J. R. Prohaska M. Broderius B. Brokate Metallochaperone for Cu, Zn-Superoxide Dismutase (Ccs) Protein but Not Mrna Is Higher in Organs from Copper-Deficient Mice and Rats Arch. Biochem. Biophys. 2003 417 227 234
11. J. Bertinato M. R. L'Abbe Copper Modulates the Degradation of Copper Chaperone for Cu, Zn Superoxide Dismutase by the 26 S Proteosome J. Biol. Chem. 2003 278 35071 35078
12. S. S. Percival M. Layden-Patrice Hl-60 Cells Can Be Made Copper Deficient by Incubating with Tetraethylenepentamine J. Nutr. 1992 122 2424 2429
13. X. Ding H. Xie Y. J. Kang The Significance of Copper Chelators in Clinical and Experimental Application J. Nutr. Biochem. 2011 22 301 310
14. G. F. Brady S. Galban X. Liu V. Basrur J. D. Gitlin K. S. Elenitoba-Johnson T. E. Wilson C. S. Duckett Regulation of the Copper Chaperone Ccs by Xiap-Mediated Ubiquitination Mol. Cell. Biol. 2010 30 1923 1936
15. J. Getz D. Lin D. M. Medeiros The Cardiac Copper Chaperone Proteins Sco1 and Ccs Are up-Regulated, but Cox 1 and Cox4 Are Down-Regulated, by Copper Deficiency Biol. Trace Elem. Res. 2011 143 368 377
16. M. Araya M. Andrews F. Pizarro M. Arredondo Chaperones Ccs, Atox and Coxiv Responses to Copper Supplementation in Healthy Adults Biometals 2012 25 383 391
17. T. R. Butt E. J. Sternberg J. A. Gorman P. Clark D. Hamer M. Rosenberg S. T. Crooke Copper metallothionein of yeast, structure of the gene, and regulation of expression PNAS 1984 81 3332 3336
18. P. Fürst S. Hu R. Hackett D. Hamer Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein Cell 1988 55 705 717
19. T. L. Blalock M. A. Dunn R. J. Cousins Metallothionein gene expression in rats: tissue-specific regulation by dietary copper and zinc J. Nutr. 1988 118 222 228
20. Y. J. Kang Metallothionein redox cycle and function Exp. Biol. Med. 2006 231 1459 1467