Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 3, 2014, Pages 802-810

  Aripirala, Srinivas ^a   Gonzalez Pacanowska, Dolores ^b   Oldfield, Eric ^c   Kaiser, Marcel ^d   Amzel, L Mario ^a   Gabelli, Sandra B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Farnesyl diphosphate synthase; FPP; IPP; Leishmania major

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; GERANYLTRANSFERASE; NITROGEN;

ANIMAL; ARTICLE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FPP; HUMAN; IPP; LEISHMANIA MAJOR; METABOLISM; PARASITOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; SKIN LEISHMANIASIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

FARNESYL DIPHOSPHATE SYNTHASE; FPP; IPP; LEISHMANIA MAJOR;

ANIMALS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHONATES; GERANYLTRANSTRANSFERASE; HUMANS; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; NITROGEN; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 84896791880     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004713033221     Document Type: Article

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