-
1
-
-
74949107560
-
Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies
-
Ducry L, Stump B (2010) Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem 21(1):5-13
-
(2010)
Bioconjug Chem
, vol.21
, Issue.1
, pp. 5-13
-
-
Ducry, L.1
Stump, B.2
-
2
-
-
84860389569
-
Trastuzumab-DM1 causes tumor growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo
-
Barok M et al (2011) Trastuzumab-DM1 causes tumor growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo. Breast Cancer Res 13(2):R46
-
(2011)
Breast Cancer Res
, vol.13
, Issue.2
, pp. R46
-
-
Barok, M.1
-
3
-
-
34447298092
-
Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance
-
Barok M et al (2007) Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance. Mol Cancer Ther 6(7):2065-2072
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.7
, pp. 2065-2072
-
-
Barok, M.1
-
4
-
-
0016724870
-
Antimitotic activity of the potent tumor inhibitor maytansine
-
Remillard S et al (1975) Antimitotic activity of the potent tumor inhibitor maytansine. Science 189(4207): 1002-1005
-
(1975)
Science
, vol.189
, Issue.4207
, pp. 1002-1005
-
-
Remillard, S.1
-
5
-
-
10744229449
-
Antibody-targeted chemotherapy with CMC-544: A CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies
-
DiJoseph JF et al (2004) Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies. Blood 103(5):1807-1814
-
(2004)
Blood
, vol.103
, Issue.5
, pp. 1807-1814
-
-
DiJoseph, J.F.1
-
6
-
-
77951648118
-
Safety, pharmacokinetics, and preliminary clinical activity of inotu- zumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a phase I study
-
Advani A et al (2010) Safety, pharmacokinetics, and preliminary clinical activity of inotu- zumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study. J Clin Oncol 28(12):2085-2093
-
(2010)
J Clin Oncol
, vol.28
, Issue.12
, pp. 2085-2093
-
-
Advani, A.1
-
7
-
-
78049515807
-
Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
-
Younes A et al (2010) Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med 363(19):1812-1821
-
(2010)
N Engl J Med
, vol.363
, Issue.19
, pp. 1812-1821
-
-
Younes, A.1
-
10
-
-
77955312203
-
Antibody-drug conjugates: Targeted drug delivery for cancer
-
Alley SC, Okeley NM, Senter PD (2010) Antibody-drug conjugates: targeted drug delivery for cancer. Curr Opin Chem Biol 14(4):529-537
-
(2010)
Curr Opin Chem Biol
, vol.14
, Issue.4
, pp. 529-537
-
-
Alley, S.C.1
Okeley, N.M.2
Senter, P.D.3
-
13
-
-
0034900174
-
Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
-
Bross PF et al (2001) Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res 7(6):1490-1496
-
(2001)
Clin Cancer Res
, vol.7
, Issue.6
, pp. 1490-1496
-
-
Bross, P.F.1
-
14
-
-
9744243565
-
Efficient elimination of B-lineage lymphomas by anti-CD20-auristatin conjugates
-
Law CL et al (2004) Efficient elimination of B-lineage lymphomas by anti-CD20-auristatin conjugates. Clin Cancer Res 10(23):7842-7851
-
(2004)
Clin Cancer Res
, vol.10
, Issue.23
, pp. 7842-7851
-
-
Law, C.L.1
-
15
-
-
33744537358
-
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates
-
Sutherland MS et al (2006) Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates. J Biol Chem 281 (15): 10540-10547
-
(2006)
J Biol Chem
, vol.281
, Issue.15
, pp. 10540-10547
-
-
Sutherland, M.S.1
-
16
-
-
41149160183
-
Contribution of linker stability to the activities of anticancer immuno- conjugates
-
Alley SC et al (2008) Contribution of linker stability to the activities of anticancer immuno- conjugates. Bioconjug Chem 19(3):759-765
-
(2008)
Bioconjug Chem
, vol.19
, Issue.3
, pp. 759-765
-
-
Alley, S.C.1
-
17
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips GD (2008) Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 68(22):9280-9290
-
(2008)
Cancer Res
, vol.68
, Issue.22
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
-
18
-
-
12244295755
-
In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate
-
Sanderson RJ et al (2005) In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res 11(2 Pt 1):843-852
-
(2005)
Clin Cancer Res
, vol.11
, Issue.2
, pp. 843-852
-
-
Sanderson, R.J.1
-
19
-
-
79951973140
-
Therapeutic monoclonal antibody concentration monitoring: Free or total
-
Kuang B, King L, Wang HF (2010) Therapeutic monoclonal antibody concentration monitoring: free or total? Bioanalysis 2(6):1125-1140
-
(2010)
Bioanalysis
, vol.2
, Issue.6
, pp. 1125-1140
-
-
Kuang, B.1
King, L.2
Wang, H.F.3
-
20
-
-
77954031486
-
Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
-
Krop IE et al (2010) Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol 28(16):2698-2704
-
(2010)
J Clin Oncol
, vol.28
, Issue.16
, pp. 2698-2704
-
-
Krop, I.E.1
-
21
-
-
10744230729
-
Recommendations for the bioanalytical method validation of ligandbinding assays to support pharmacokinetic assessments of macromolecules
-
DeSilva B et al (2003) Recommendations for the bioanalytical method validation of ligandbinding assays to support pharmacokinetic assessments of macromolecules. Pharm Res 20(11):1885-1900
-
(2003)
Pharm Res
, vol.20
, Issue.11
, pp. 1885-1900
-
-
DeSilva, B.1
-
22
-
-
0003484310
-
-
Weblink last assessed January 3
-
FDA (2001) Guidance for Industry: Bioanalytical Method Validation. Weblink last assessed January 3, 2012: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatory Information/ Guidances/ucm070107. pdf
-
(2001)
Guidance for Industry: Bioanalytical Method Validation
-
-
-
23
-
-
6044223544
-
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
-
Hamblett KJ et al (2004) Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. Clin Cancer Res 10(20):7063-7070
-
(2004)
Clin Cancer Res
, vol.10
, Issue.20
, pp. 7063-7070
-
-
Hamblett, K.J.1
-
24
-
-
33745684533
-
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment
-
McDonagh CF et al (2006) Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment. Protein Eng Des Sel 19(7):299-307
-
(2006)
Protein Eng Des Sel
, vol.19
, Issue.7
, pp. 299-307
-
-
McDonagh, C.F.1
-
25
-
-
0016275147
-
Inheritance of antibody specificity. I. Anti-(4-hydroxy-3- nitrophenyl)acetyl of the mouse primary response
-
Imanishi T, Makela O (1974) Inheritance of antibody specificity. I. Anti-(4-hydroxy-3- nitrophenyl)acetyl of the mouse primary response. J Exp Med 140(6):1498-1510
-
(1974)
J Exp Med
, vol.140
, Issue.6
, pp. 1498-1510
-
-
Imanishi, T.1
Makela, O.2
-
26
-
-
0015954408
-
Inheritance of fine-specificity in mouse anti-hapten antibodies
-
Imanishi T, Makela O (1974) Inheritance of fine-specificity in mouse anti-hapten antibodies. Ann Immunol (Paris) 125C(1-2):199-200
-
(1974)
Ann Immunol (Paris)
, vol.125 C
, Issue.1-2
, pp. 199-200
-
-
Imanishi, T.1
Makela, O.2
-
27
-
-
0019442186
-
Heavy chain variable region contribution to the NPb family of antibodies: Somatic mutation evident in a gamma 2a variable region
-
Bothwell AL et al (1981) Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell 24(3):625-637
-
(1981)
Cell
, vol.24
, Issue.3
, pp. 625-637
-
-
Bothwell, A.L.1
-
28
-
-
0022386943
-
Molecular events during maturation of the immune response to oxazolone
-
Berek C, Griffiths GM, Milstein C (1985) Molecular events during maturation of the immune response to oxazolone. Nature 316(6027):412-418
-
(1985)
Nature
, vol.316
, Issue.6027
, pp. 412-418
-
-
Berek, C.1
Griffiths, G.M.2
Milstein, C.3
-
29
-
-
0014802662
-
Hapten specificity of cellular immune responses as compared with the specificity of serum anti-hapten antibody
-
Paul WE, Siskind GW (1970) Hapten specificity of cellular immune responses as compared with the specificity of serum anti-hapten antibody. Immunology 18(6):921-930
-
(1970)
Immunology
, vol.18
, Issue.6
, pp. 921-930
-
-
Paul, W.E.1
Siskind, G.W.2
-
30
-
-
0016204051
-
Induction of anti-hapten antibody response by hapten-isologous carrier conjugate. I. Development of hapten-reactive helper cells by hapten-isologous carrier
-
Yamashita U, Kitagawa M (1974) Induction of anti-hapten antibody response by hapten-isologous carrier conjugate. I. Development of hapten-reactive helper cells by hapten-isologous carrier. Cell Immunol 14(2):182-192
-
(1974)
Cell Immunol
, vol.14
, Issue.2
, pp. 182-192
-
-
Yamashita, U.1
Kitagawa, M.2
-
31
-
-
77953658260
-
The immunogenicity ofhumanized and fully human antibodies: Residual immunogenicity resides in the CDR regions
-
Harding FA et al (2010) The immunogenicity ofhumanized and fully human antibodies: residual immunogenicity resides in the CDR regions. MAbs 2(3):256-265
-
(2010)
MAbs
, vol.2
, Issue.3
, pp. 256-265
-
-
Harding, F.A.1
-
32
-
-
47549097069
-
Epoetin-associated pure red cell aplasia: Past, present, and future considerations
-
McKoy JM et al (2008) Epoetin-associated pure red cell aplasia: past, present, and future considerations. Transfusion 48(8):1754-1762
-
(2008)
Transfusion
, vol.48
, Issue.8
, pp. 1754-1762
-
-
McKoy, J.M.1
-
33
-
-
79952534748
-
Taking immunogenicity assessment of therapeutic proteins to the next level
-
Buttel IC et al (2011) Taking immunogenicity assessment of therapeutic proteins to the next level. Biologicals 39(2):100-109
-
(2011)
Biologicals
, vol.39
, Issue.2
, pp. 100-109
-
-
Buttel, I.C.1
-
34
-
-
79953103751
-
Regulatory considerations for development of bioanalytical assays for biotechnology products
-
Swann PG, Shapiro MA (2011) Regulatory considerations for development of bioanalytical assays for biotechnology products. Bioanalysis 3(6):597-603
-
(2011)
Bioanalysis
, vol.3
, Issue.6
, pp. 597-603
-
-
Swann, P.G.1
Shapiro, M.A.2
-
35
-
-
78649642694
-
Have we overestimated the benefit of human(ized) antibodies
-
Getts DR et al (2010) Have we overestimated the benefit of human(ized) antibodies? MAbs 2(6):682-694
-
(2010)
MAbs
, vol.2
, Issue.6
, pp. 682-694
-
-
Getts, D.R.1
-
40
-
-
0003556719
-
-
Weblink last assessed January 3
-
FDA (1999) Guidance for Industry: Population Pharmacokinetics. Weblink last assessed January 3, 2012: http://www.fda.gov/downloads/ScienceResearch/SpecialTopics/WomensHealth Research/UCM133184.pdf
-
(1999)
Guidance for Industry: Population Pharmacokinetics
-
-
-
41
-
-
77957830531
-
Electrocardiographic assessment for therapeutic proteins-scientific discussion
-
Rodriguez I et al (2010) Electrocardiographic assessment for therapeutic proteins-scientific discussion. Am Heart J 160(4):627-634
-
(2010)
Am Heart J
, vol.160
, Issue.4
, pp. 627-634
-
-
Rodriguez, I.1
-
42
-
-
40249094483
-
Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development
-
Curigliano G et al (2008) Drug-induced QTc interval prolongation: a proposal towards an efficient and safe anticancer drug development. Eur J Cancer 44(4):494-500
-
(2008)
Eur J Cancer
, vol.44
, Issue.4
, pp. 494-500
-
-
Curigliano, G.1
-
43
-
-
64349093768
-
Assessing proarrhythmic potential of drugs when optimal studies are infeasible
-
Rock EP et al (2009) Assessing proarrhythmic potential of drugs when optimal studies are infeasible. Am Heart J 157(5):827-836, 836.e1
-
(2009)
Am Heart J
, vol.157
, Issue.5
-
-
Rock, E.P.1
-
44
-
-
44949175102
-
Challenges of characterizing proarrhythmic risk due to QTc prolongation induced by nonadjuvant anticancer agents
-
Sarapa N, Britto MR (2008) Challenges of characterizing proarrhythmic risk due to QTc prolongation induced by nonadjuvant anticancer agents. Expert Opin Drug Saf 7(3):305-318
-
(2008)
Expert Opin Drug Saf
, vol.7
, Issue.3
, pp. 305-318
-
-
Sarapa, N.1
Britto, M.R.2
-
45
-
-
54249165398
-
Clinical pharmacology in the era of biotherapeutics
-
Lalonde RL, Honig P (2008) Clinical pharmacology in the era of biotherapeutics. Clin Pharmacol Ther 84(5):533-536
-
(2008)
Clin Pharmacol Ther
, vol.84
, Issue.5
, pp. 533-536
-
-
Lalonde, R.L.1
Honig, P.2
-
46
-
-
75149145545
-
Pharmacokinetics and pharmacodynamics of monoclonal antibodies: Concepts and lessons for drug development
-
Mould DR, Green B (2010) Pharmacokinetics and pharmacodynamics of monoclonal antibodies: concepts and lessons for drug development. BioDrugs 24(1):23-39
-
(2010)
BioDrugs
, vol.24
, Issue.1
, pp. 23-39
-
-
Mould, D.R.1
Green, B.2
|