Antibiotic prophylaxis at elective cesarean section: A randomized controlled trial in a low resource setting

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 27, Issue 6, 2014, Pages 588-591

  Kandil, Mohamed ^a   Sanad, Zakaria ^a   Gaber, Wael ^a  

^a MENOUFIA UNIVERSITY   (Egypt)

Author keywords

Antibiotics; Cesarean; Cord clamping; Skin incision

Indexed keywords

CEFAZOLIN; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC PROPHYLAXIS; ARTICLE; ASTHMA; CESAREAN SECTION; CONTROLLED STUDY; DRUG EFFICACY; ENDOMETRITIS; FEMALE; HEART DISEASE; HUMAN; INFECTION RISK; INTRAUTERINE GROWTH RETARDATION; MACROSOMIA; MAJOR CLINICAL STUDY; MALPRESENTATION; MATERNAL MORBIDITY; OUTCOME ASSESSMENT; PLACENTA PREVIA; POSTOPERATIVE INFECTION; PRIMIGRAVIDA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SKIN INCISION; SURGICAL INFECTION; SURGICAL TECHNIQUE; TREATMENT INDICATION; UMBILICAL CORD CLAMPING; URINARY TRACT INFECTION; ECONOMICS; ELECTIVE SURGERY; HEALTH CARE PLANNING; POVERTY; PREGNANCY; STATISTICS AND NUMERICAL DATA; SURGICAL WOUND INFECTION; URINARY TRACT INFECTIONS; YOUNG ADULT;

ADULT; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CEFAZOLIN; CESAREAN SECTION; ELECTIVE SURGICAL PROCEDURES; ENDOMETRITIS; FEMALE; HEALTH RESOURCES; HUMANS; POVERTY; PREGNANCY; SURGICAL WOUND INFECTION; URINARY TRACT INFECTIONS; YOUNG ADULT;

EID: 84896773672     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2013.823938     Document Type: Article

References (19)

1. Bremmelgaard A, Raahave D, Beir-Holgersen R, et al. Computeraided surveillance of surgical infections and identification of risk factors. J Hosp Infect 1989;13:1-18.
2. Haley RW, Culver DH, Morgan WM, et al. Identifying patients at high risk of surgical wound infection: a simple multivariate index of patient susceptibility and wound contamination. Am J Epidemiol 1985;121:206-15.
3. Kurz A, Sessler DI, Lenhardt RA. Study of wound infections and temperature group. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. N Engl J Med 1996;334:1209-15.
4. Smaill FM, Gyte GML. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. Cochrane Database Systemat Rev 2010;1:CD007482.
5. Jensen JA, Goodson WH, Hopf HW, Hunt TK. Cigarette smoking decreases tissue oxygen. Arch Surg 1991;126:1131-4.
6. Sullivan SA, Smith T, Chang E, et al. Administration of cefazolin prior to skin incision is superior to cefazolin at cord clamping in preventing post Cesarean infectious morbidity: a randomized, controlled trial. Am J Obstet Gynecol 2007;196:455.e1-5.
7. Schulz KF. Randomized controlled trials. Clin Obstet Gynecol 1998;41:245-56.
8. Myles TD, Gooch J, Santolaya J. Obesity as an independent risk factor for infectious morbidity in patients who undergo cesarean delivery. Obstet Gynecol 2002;100:959-64.
9. Wilson JA, Clark JJ. Obesity: impediment to postsurgical wound healing. Adv Skin Wound Care 2004;17:426-35.
10. Tharpe N. Postpregnancy genital tract and wound infections. J Midwifery Womens Health 2008;53:236-46.
11. Wloch C, Wilson J, Lamagni T, et al. Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study. BJOG 2012;119:1324-33.
12. Yeung LL, Grewal S, Bullock A, et al. A comparison of chlorhexidine-alcohol versus povidone-iodine for eliminating skin flora before genitourinary prosthetic surgery: a randomized controlled trial. J Urol 2013;189:136-40.
13. Sessler DI. Non-pharmacologic Prevention of Surgical Wound Infection. Anesthesiol Clin 2006;24:279-97.
14. Yildirim G, Gungorduk K, Guven HZ, et al. When should we perform prophylactic antibiotics in elective cesarean cases? Arch Gynecol Obstet 2009;280:13-8.
15. Witt A, Doner M, Petricevic L, et al. Antibiotic prophylaxis before surgery vs after cord clamping in elective cesarean delivery: a double-blind, prospective, randomized, placebo-controlled trial. Arch Surg 2011;146:1404-9.
16. Lamont RF, Sobel J, Kusanovic JP, et al. Current debate on the use of antibiotic prophylaxis for cesarean section. BJOG 2011;118: 193-201.
17. Thigpen BD, Hood WA, Chauhan S, et al. Timing of prophylactic antibiotic administration in the uninfected laboring gravida: a randomized clinical trial. Am J Obstet Gynecol 2005;192:1864-8.
18. Wax JR, Hersey K, Philput C, et al. Single dose cefazolin prophylaxis for postcesarean infections: before vs. after cord clamping. J Matern Fetal Med 1997;6:61-5.
19. Macones GA, Cleary KL, Parry S, et al. The timing of antibiotics at cesarean: a randomized controlled trial. Am J Perinatol 2012;29: 273-6.