Immunological changes and increased expression of myxovirus resistance protein A in thyroid tissue of patients with recent onset and untreated graves' disease

Thyroid

Volumn 24, Issue 3, 2014, Pages 537-544

  Hammerstad, Sara Salehi ^a   Jahnsen, Frode Lars ^b   Tauriainen, Sisko ^c,d   Hyöty, Heikki ^d,e   Paulsen, Trond ^a   Norheim, Ingrid ^a   Dahl Jørgensen, Knut ^f,g  

^a AKER UNIVERSITY HOSPITAL   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF TURKU   (Finland)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^e PIRKANMAA HOSPITAL DISTRICT   (Finland)

^f UNIVERSITY OF OSLO   (Norway)

^g ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIMAZOLE; METHYLPREDNISOLONE; MYXOVIRUS RESISTANCE PROTEIN A; PREDNISOLONE; SYNDECAN 1;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; FEMALE; FIBROSIS; GRAVES DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE; MALE; MIDDLE AGED; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID GLAND; VIRUS INFECTION;

ADULT; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; GRAVES DISEASE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MYXOVIRUS RESISTANCE PROTEINS; THYROID GLAND;

EID: 84896757819     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2013.0287     Document Type: Article

References (43)

1. Tomer Y, Davies TF 2003 Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr Rev 24:694-717.
2. Weetman AP 2003 Autoimmune thyroid disease: propagation and progression. Eur J Endocrinol 148:1-9.
3. Weetman AP 2000 Graves' disease. N Engl J Med 343: 1236-1248.
4. Brix TH, Christensen K, Holm NV, Harvald B, Hegedus L 1998 A population-based study of Graves' disease in Danish twins. Clin Endocrinol (Oxf) 48:397-400.
5. Brix TH, Kyvik KO, Christensen K, Hegedus L 2001 Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab 86:930-934.
6. Ringold DA, Nicoloff JT, Kesler M, Davis H, Hamilton A, Mack T 2002 Further evidence for a strong genetic influence on the development of autoimmune thyroid disease: the California twin study. Thyroid 12:647-653.
7. Li Y, Bourlet T, Andreoletti L, Mosnier JF, Peng T, Yang Y, Archard LC, Pozzetto B, Zhang H 2000 Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. Circulation 101:231-234.
8. Kuhl U 2005 Antiviral treatment of myocarditis and acute dilated cardiomyopathy. Heart Fail Clin 1:467-474.
9. Oikarinen M, Tauriainen S, Oikarinen S, Honkanen T, Collin P, Rantala I, Maki M, Kaukinen K, Hyoty H 2012 Type 1 diabetes is associated with enterovirus infection in gut mucosa. Diabetes 61:687-691.
10. Casiraghi C, Shanina I, Cho S, Freeman ML, Blackman MA, Horwitz MS 2012 Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis. PLoS Pathog 8:e1002715.
11. Desailloud R, Hober D 2009 Viruses and thyroiditis: an update. Virol J 6:5.
12. Hammerstad SS, Tauriainen S, Hyoty H, Paulsen T, Norheim I, Dahl-Jorgensen K 2013 Detection of enterovirus in the thyroid tissue of patients with Graves' disease. J Med Virol 85:512-518.
13. Mori K, Yoshida K 2010 Viral infection in induction of Hashimoto's thyroiditis: a key player or just a bystander? Curr Opin Endocrinol Diabetes Obes 17:418-424.
14. Haller O, Weber F 2009 The interferon response circuit in antiviral host defense. Verh K Acad Geneeskd Belg 71:73-86.
15. Sadler AJ, Williams BR 2008 Interferon-inducible antiviral effectors. Nat Rev Immunol 8:559-568.
16. Kvale EO, Dalgaard J, Lund-Johansen F, Rollag H, Farkas L, Midtvedt K, Jahnsen FL, Brinchmann JE, Olweus J 2006 CD11c + dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cellstimulatory capability upon infection. Blood 107:2022-2029.
17. Farkas L, Beiske K, Lund-Johansen F, Brandtzaeg P, Jahnsen FL 2001 Plasmacytoid dendritic cells (natural interferonalpha/ beta-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am J Pathol 159:237-243.
18. Hammerstad SS, Jahnsen FL, Tauriainen S, Hyoty H, Paulsen T, Norheim I, Dahl-Jorgensen K 2013 Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto's thyroiditis. Thyroid 23:334-341.
19. Jahnsen FL, Lund-Johansen F, Dunne JF, Farkas L, Haye R, Brandtzaeg P 2000 Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J Immunol 165:4062-4068.
20. Jahnsen FL, Farkas L, Lund-Johansen F, Brandtzaeg P 2002 Involvement of plasmacytoid dendritic cells in human diseases. Hum Immunol 63:1201-1205.
21. Flohr F, Schneider-Schaulies S, Haller O, Kochs G 1999 The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures. FEBS Lett 463:24-28.
22. Iwatani Y, Amino N, Hidaka Y, Kaneda T, Ichihara K, Tamaki H, Matsuzuka F, Fukata S, Kuma K, Miyai K 1992 Decreases in alpha beta T cell receptor negative T cells and CD8 cells, and an increase in CD4 + CD8+ cells in active Hashimoto's disease and subacute thyroiditis. Clin Exp Immunol 87:444-449.
23. Bossowski A, Urban M, Stasiak-Barmuta A 2003 Analysis of changes in the percentage of B (CD19) and T (CD3) lymphocytes, subsets CD4, CD8 and their memory (CD45RO), and naive (CD45RA) T cells in children with immune and non-immune thyroid diseases. J Pediatr Endocrinol Metab 16:63-70.
24. Covas MI, Esquerda A, Garcia-Rico A, Mahy N 1992 Peripheral blood T-lymphocyte subsets in autoimmune thyroid disease. J Investig Allergol Clin Immunol 2:131-135.
25. Samuel CE 1994 Interferon-induced proteins and their mechanisms of action. Hokkaido Igaku Zasshi 69:1339-1347.
26. Shiroozu A, Taurog A, Engler H, Dorris ML 1983 Mechanism of action of thioureylene antithyroid drugs in the rat: possible inactivation of thyroid peroxidase by propylthiouracil. Endocrinology 113:362-370.
27. Engler H, Taurog A, Luthy C, Dorris ML 1983 Reversible and irreversible inhibition of thyroid peroxidase-catalyzed iodination by thioureylene drugs. Endocrinology 112:86-95.
28. Ronnblom LE, Alm GV, Oberg KE 1991 Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors. Ann Intern Med 115:178-183.
29. Akeno N, Smith EP, Stefan M, Huber AK, Zhang W, Keddache M, Tomer Y 2011 IFN-alpha mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms. J Immunol 186:4693-4706.
30. Prummel MF, Laurberg P 2003 Interferon-alpha and autoimmune thyroid disease. Thyroid 13:547-551.
31. Mukherjee A, Morosky SA, Delorme-Axford E, Dybdahl-Sissoko N, Oberste MS, Wang T, Coyne CB 2011 The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. PLoS Pathog 7:e1001311.
32. Lei X, Sun Z, Liu X, Jin Q, He B, Wang J 2011 Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 85:8811-8818.
33. Ruiz-Riol M, Barnils MP, Colobran OR, Pla AS, Borras Serres FE, Lucas-Martin A, Martinez Caceres EM, Pujol-Borrell R 2011 Analysis of the cumulative changes in Graves' disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors. J Autoimmun 36:189-200.
34. Wang X, Magro CM 2012 Human Myxovirus Resistance Protein 1 (MxA) as a useful marker in the differential diagnosis of subcutaneous lymphoma vs. lupus erythematosus profundus. Eur J Dermatol 22:629-633.
35. Heier I, Soyland E, Krogstad AL, Rodriguez-Gallego C, Nenseter MS, Jahnsen FL 2011 Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin. Br J Dermatol 165:792-801.
36. van der Voort LF, Vennegoor A, Visser A, Knol DL, Uitdehaag BM, Barkhof F, Oudejans CB, Polman CH, Killestein J 2010 Spontaneous MxA mRNA level predicts relapses in patients with recently diagnosed MS. Neurology 75:1228-1233.
37. Zanotti C, Ghidini C, Lamorgese C, Caimi L, Capra R, Imberti L 2010 Transfer of myxovirus-protein-A mRNA assay for interferon-beta bioactivity measurement in multiple sclerosis patients to routine laboratory practice. A 4-year experience. Clin Chem Lab Med 48:1235-1238.
38. Ben-Skowronek I, Sierocinska-Sawa J, Szewczyk L, Korobowicz E 2009 Interaction of lymphocytes and thyrocytes in Graves' disease and nonautoimmune thyroid diseases in immunohistochemical and ultrastructural investigations. Horm Res 71:350-358.
39. Callan MF, Tan L, Annels N, Ogg GS, Wilson JD, O'Callaghan CA, Steven N, McMichael AJ, Rickinson AB 1998 Direct visualization of antigen-specific CD8 + T cells during the primary immune response to Epstein-Barr virus in vivo. J Exp Med 187:1395-1402.
40. Asquith B, Mosley AJ, Barfield A, Marshall SE, Heaps A, Goon P, Hanon E, Tanaka Y, Taylor GP, Bangham CR 2005 A functional CD8+ cell assay reveals individual variation in CD8 + cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load. J Gen Virol 86:1515-1523.
41. Murali-Krishna K, Altman JD, Suresh M, Sourdive DJ, Zajac AJ, Miller JD, Slansky J, Ahmed R 1998 Counting antigenspecific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177-187.
42. Volpe R 2001 The immunomodulatory effects of anti-thyroid drugs are mediated via actions on thyroid cells, affecting thyrocyte-immunocyte signalling: a review. Curr Pharm Des 7:451-460.
43. Konishi T, Okamoto Y, Ueda M, Fukuda Y, Harusato I, Tsukamoto Y, Hamada N 2011 Drug discontinuation after treatment with minimum maintenance dose of an antithyroid drug in Graves' disease: a retrospective study on effects of treatment duration with minimum maintenance dose on lasting remission. Endocr J 58:95-100.