Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody

Cancer immunology research

Volumn 1, Issue 3, 2013, Pages 163-

  Choi, Bryan D ^a   Gedeon, Patrick C ^a   Herndon, James E ^a   Archer, Gary E ^a   Reap, Elizabeth A ^a   Sanchez Perez, Luis ^a   Mitchell, Duane A ^a   Bigner, Darell D ^a   Sampson, John H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bispecific Antibodies; Glioblastoma; Granzymes; Immunomodulation; Regulatory T Cells

Indexed keywords

BISPECIFIC ANTIBODY; GRANZYME; PERFORIN;

CYTOTOXICITY; GLIOBLASTOMA; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; REGULATORY T LYMPHOCYTE; TUMOR CELL LINE;

ANTIBODIES, BISPECIFIC; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; GLIOBLASTOMA; GRANZYMES; HUMANS; LYMPHOCYTE ACTIVATION; PERFORIN; T-LYMPHOCYTES, REGULATORY;

EID: 84896738113     PISSN: None     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-13-0049     Document Type: Article

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