메뉴 건너뛰기




Volumn 42, Issue 2, 2014, Pages 74-82.e2

Heterogeneity and hierarchy of hematopoietic stem cells

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL SURVIVAL; CLASSIFICATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INTERMEDIATE TERM HEMATOPOIETIC STEM CELL; LONG TERM HEMATOPOIETIC STEM CELL; LYMPHOID BIASED HEMATOPOIETIC STEM CELL; MULTILINEAGE RECONSTITUTION; MYELOID BIASED HEMATOPOIETIC STEM CELL; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; REGENERATION; REVIEW; SHORT TERM HEMATOPOIETIC STEM CELL;

EID: 84896727582     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2013.11.004     Document Type: Review
Times cited : (104)

References (63)
  • 1
    • 78651158197 scopus 로고
    • A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells
    • Till J.E., McCulloch E.A., Siminovitch L. A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells. Proc Natl Acad Sci U S A 1964, 51:29-36.
    • (1964) Proc Natl Acad Sci U S A , vol.51 , pp. 29-36
    • Till, J.E.1    McCulloch, E.A.2    Siminovitch, L.3
  • 2
    • 0035228050 scopus 로고    scopus 로고
    • Distinct classes of human stem cells that differ in proliferative and self-renewal potential
    • Guenechea G., Gan O.I., Dorrell C., Dick J.E. Distinct classes of human stem cells that differ in proliferative and self-renewal potential. Nat Immunol 2001, 2:75-82.
    • (2001) Nat Immunol , vol.2 , pp. 75-82
    • Guenechea, G.1    Gan, O.I.2    Dorrell, C.3    Dick, J.E.4
  • 3
    • 19944400789 scopus 로고    scopus 로고
    • Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice
    • Ema H., Sudo K., Seita J., et al. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev Cell 2005, 8:907-914.
    • (2005) Dev Cell , vol.8 , pp. 907-914
    • Ema, H.1    Sudo, K.2    Seita, J.3
  • 4
    • 84860343741 scopus 로고    scopus 로고
    • Stem cell heterogeneity: implications for aging and regenerative medicine
    • Muller-Sieburg C.E., Sieburg H.B., Bernitz J.M., Cattarossi G. Stem cell heterogeneity: implications for aging and regenerative medicine. Blood 2012, 119:3900-3907.
    • (2012) Blood , vol.119 , pp. 3900-3907
    • Muller-Sieburg, C.E.1    Sieburg, H.B.2    Bernitz, J.M.3    Cattarossi, G.4
  • 5
    • 84862532139 scopus 로고    scopus 로고
    • Hematopoietic stem cell heterogeneity takes center stage
    • Copley M.R., Beer P.A., Eaves C.J. Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell 2012, 10:690-697.
    • (2012) Cell Stem Cell , vol.10 , pp. 690-697
    • Copley, M.R.1    Beer, P.A.2    Eaves, C.J.3
  • 6
    • 0029796633 scopus 로고    scopus 로고
    • Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
    • Osawa M., Hanada K., Hamada H., Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996, 273:242-245.
    • (1996) Science , vol.273 , pp. 242-245
    • Osawa, M.1    Hanada, K.2    Hamada, H.3    Nakauchi, H.4
  • 8
    • 15944363056 scopus 로고    scopus 로고
    • Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients
    • Yang L., Bryder D., Adolfsson J., et al. Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood 2005, 105:2717-2723.
    • (2005) Blood , vol.105 , pp. 2717-2723
    • Yang, L.1    Bryder, D.2    Adolfsson, J.3
  • 9
    • 0022355684 scopus 로고
    • Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice
    • Dick J.E., Magli M.C., Huszar D., Phillips R.A., Bernstein A. Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell 1985, 42:71-79.
    • (1985) Cell , vol.42 , pp. 71-79
    • Dick, J.E.1    Magli, M.C.2    Huszar, D.3    Phillips, R.A.4    Bernstein, A.5
  • 10
    • 0022365333 scopus 로고
    • Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors
    • Keller G., Paige C., Gilboa E., Wagner E.F. Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature 1985, 318:149-154.
    • (1985) Nature , vol.318 , pp. 149-154
    • Keller, G.1    Paige, C.2    Gilboa, E.3    Wagner, E.F.4
  • 11
    • 0022474392 scopus 로고
    • Developmental potential and dynamic behavior of hematopoietic stem cells
    • Lemischka I.R., Raulet D.H., Mulligan R.C. Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 1986, 45:917-927.
    • (1986) Cell , vol.45 , pp. 917-927
    • Lemischka, I.R.1    Raulet, D.H.2    Mulligan, R.C.3
  • 12
    • 0025176833 scopus 로고
    • Clonal and systemic analysis of long-term hematopoiesis in the mouse
    • Jordan C.T., Lemischka I.R. Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev 1990, 4:220-232.
    • (1990) Genes Dev , vol.4 , pp. 220-232
    • Jordan, C.T.1    Lemischka, I.R.2
  • 13
    • 0037103312 scopus 로고    scopus 로고
    • Deterministic regulation of hematopoietic stem cell self-renewal and differentiation
    • Muller-Sieburg C.E., Cho R.H., Thoman M., Adkins B., Sieburg H.B. Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. Blood 2002, 100:1302-1309.
    • (2002) Blood , vol.100 , pp. 1302-1309
    • Muller-Sieburg, C.E.1    Cho, R.H.2    Thoman, M.3    Adkins, B.4    Sieburg, H.B.5
  • 14
    • 2542473275 scopus 로고    scopus 로고
    • Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness
    • Muller-Sieburg C.E., Cho R.H., Karlsson L., Huang J.F., Sieburg H.B. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood 2004, 103:4111-4118.
    • (2004) Blood , vol.103 , pp. 4111-4118
    • Muller-Sieburg, C.E.1    Cho, R.H.2    Karlsson, L.3    Huang, J.F.4    Sieburg, H.B.5
  • 15
    • 47049099198 scopus 로고    scopus 로고
    • A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells
    • Cho R.H., Sieburg H.B., Muller-Sieburg C.E. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 2008, 111:5553-5561.
    • (2008) Blood , vol.111 , pp. 5553-5561
    • Cho, R.H.1    Sieburg, H.B.2    Muller-Sieburg, C.E.3
  • 16
    • 34547692981 scopus 로고    scopus 로고
    • Long-term propagation of distinct hematopoietic differentiation programs invivo
    • Dykstra B., Kent D., Bowie M., et al. Long-term propagation of distinct hematopoietic differentiation programs invivo. Cell Stem Cell 2007, 1:218-229.
    • (2007) Cell Stem Cell , vol.1 , pp. 218-229
    • Dykstra, B.1    Kent, D.2    Bowie, M.3
  • 17
    • 84857873445 scopus 로고    scopus 로고
    • Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs
    • Benz C., Copley M.R., Kent D.G., et al. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell 2012, 10:273-283.
    • (2012) Cell Stem Cell , vol.10 , pp. 273-283
    • Benz, C.1    Copley, M.R.2    Kent, D.G.3
  • 18
    • 77449145533 scopus 로고    scopus 로고
    • Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1
    • Challen G.A., Boles N.C., Chambers S.M., Goodell M.A. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell 2010, 6:265-278.
    • (2010) Cell Stem Cell , vol.6 , pp. 265-278
    • Challen, G.A.1    Boles, N.C.2    Chambers, S.M.3    Goodell, M.A.4
  • 19
    • 77953512588 scopus 로고    scopus 로고
    • Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
    • Morita Y., Ema H., Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med 2010, 207:1173-1182.
    • (2010) J Exp Med , vol.207 , pp. 1173-1182
    • Morita, Y.1    Ema, H.2    Nakauchi, H.3
  • 20
    • 73049110615 scopus 로고    scopus 로고
    • Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential
    • Benveniste P., Frelin C., Janmohamed S., et al. Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell 2010, 6:48-58.
    • (2010) Cell Stem Cell , vol.6 , pp. 48-58
    • Benveniste, P.1    Frelin, C.2    Janmohamed, S.3
  • 21
    • 84883428326 scopus 로고    scopus 로고
    • Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells
    • Yamamoto R., Morita Y., Ooehara J., et al. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell 2013, 154:1112-1126.
    • (2013) Cell , vol.154 , pp. 1112-1126
    • Yamamoto, R.1    Morita, Y.2    Ooehara, J.3
  • 22
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K., Traver D., Miyamoto T., Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000, 404:193-197.
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 23
    • 0033105493 scopus 로고    scopus 로고
    • Emergence of Tcell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver
    • Kawamoto H., Ohmura K., Fujimoto S., Katsura Y. Emergence of Tcell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver. J Immunol 1999, 162:2725-2731.
    • (1999) J Immunol , vol.162 , pp. 2725-2731
    • Kawamoto, H.1    Ohmura, K.2    Fujimoto, S.3    Katsura, Y.4
  • 24
    • 20244387299 scopus 로고    scopus 로고
    • Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
    • Adolfsson J., Månsson R., Buza-Vidas N., et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 2005, 121:295-306.
    • (2005) Cell , vol.121 , pp. 295-306
    • Adolfsson, J.1    Månsson, R.2    Buza-Vidas, N.3
  • 25
    • 84885634008 scopus 로고    scopus 로고
    • Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
    • Sanjuan-Pla A., Macaulay I.C., Jensen C.T., et al. Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. Nature 2013, 502:232-236.
    • (2013) Nature , vol.502 , pp. 232-236
    • Sanjuan-Pla, A.1    Macaulay, I.C.2    Jensen, C.T.3
  • 26
    • 67650587142 scopus 로고    scopus 로고
    • Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential
    • Kent D.G., Copley M.R., Benz C., et al. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood 2009, 113:6342-6350.
    • (2009) Blood , vol.113 , pp. 6342-6350
    • Kent, D.G.1    Copley, M.R.2    Benz, C.3
  • 27
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till J.E., McCullouch E.A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 1961, 14:213-222.
    • (1961) Radiat Res , vol.14 , pp. 213-222
    • Till, J.E.1    McCullouch, E.A.2
  • 28
    • 0015321340 scopus 로고
    • Competitive invivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice
    • Micklem H.S., Ford C.E., Evans E.P., Ogden D.A., Papworth D.S. Competitive invivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice. J Cell Physiol 1972, 79:293-298.
    • (1972) J Cell Physiol , vol.79 , pp. 293-298
    • Micklem, H.S.1    Ford, C.E.2    Evans, E.P.3    Ogden, D.A.4    Papworth, D.S.5
  • 29
    • 0027893247 scopus 로고
    • Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations
    • Harrison D.E., Jordan C.T., Zhong R.K., Astle C.M. Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp Hematol 1993, 21:206-219.
    • (1993) Exp Hematol , vol.21 , pp. 206-219
    • Harrison, D.E.1    Jordan, C.T.2    Zhong, R.K.3    Astle, C.M.4
  • 30
    • 0025205255 scopus 로고
    • Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy
    • Szilvassy S.J., Humphries R.K., Lansdorp P.M., Eaves A.C., Eaves C.J. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci US A 1990, 87:8736-8740.
    • (1990) Proc Natl Acad Sci US A , vol.87 , pp. 8736-8740
    • Szilvassy, S.J.1    Humphries, R.K.2    Lansdorp, P.M.3    Eaves, A.C.4    Eaves, C.J.5
  • 31
    • 0034177619 scopus 로고    scopus 로고
    • Expansion of hematopoietic stem cells in the developing liver of a mouse embryo
    • Ema H., Nakauchi H. Expansion of hematopoietic stem cells in the developing liver of a mouse embryo. Blood 2000, 95:2284-2288.
    • (2000) Blood , vol.95 , pp. 2284-2288
    • Ema, H.1    Nakauchi, H.2
  • 32
    • 1342321666 scopus 로고    scopus 로고
    • Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs
    • Takano H., Ema H., Sudo K., Nakauchi H. Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med 2004, 199:295-302.
    • (2004) J Exp Med , vol.199 , pp. 295-302
    • Takano, H.1    Ema, H.2    Sudo, K.3    Nakauchi, H.4
  • 33
    • 0025080454 scopus 로고
    • Effects of transplantation on the primitive immunohematopoietic stem cell
    • Harrison D.E., Stone M., Astle C.M. Effects of transplantation on the primitive immunohematopoietic stem cell. J Exp Med 1990, 172:431-437.
    • (1990) J Exp Med , vol.172 , pp. 431-437
    • Harrison, D.E.1    Stone, M.2    Astle, C.M.3
  • 34
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M., Weissman I.L., Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997, 91661-91672.
    • (1997) Cell , pp. 91661-91672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 35
    • 0035337478 scopus 로고    scopus 로고
    • The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages
    • Mebius R.E., Miyamoto T., Christensen J., et al. The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages. J Immunol 2001, 166:6593-6601.
    • (2001) J Immunol , vol.166 , pp. 6593-6601
    • Mebius, R.E.1    Miyamoto, T.2    Christensen, J.3
  • 36
    • 0035437127 scopus 로고    scopus 로고
    • Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
    • Traver D., Miyamoto T., Christensen J., Iwasaki-Arai J., Akashi K., Weissman I.L. Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets. Blood 2001, 98:627-635.
    • (2001) Blood , vol.98 , pp. 627-635
    • Traver, D.1    Miyamoto, T.2    Christensen, J.3    Iwasaki-Arai, J.4    Akashi, K.5    Weissman, I.L.6
  • 37
    • 0030962093 scopus 로고    scopus 로고
    • Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver
    • Kawamoto H., Ohmura K., Katsura Y. Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver. Int Immunol 1997, 9:1011-1019.
    • (1997) Int Immunol , vol.9 , pp. 1011-1019
    • Kawamoto, H.1    Ohmura, K.2    Katsura, Y.3
  • 38
    • 0026737664 scopus 로고
    • Studies on T cell maturation on defined thymic stromal cell populations invitro
    • Jenkinson E.J., Anderson G., Owen J.J. Studies on T cell maturation on defined thymic stromal cell populations invitro. J Exp Med 1992, 176:845-853.
    • (1992) J Exp Med , vol.176 , pp. 845-853
    • Jenkinson, E.J.1    Anderson, G.2    Owen, J.J.3
  • 39
    • 0036785585 scopus 로고    scopus 로고
    • The common myelolymphoid progenitor: a key intermediate stage in hemopoiesis generating T and B cells
    • Lu M., Kawamoto H., Katsube Y., Ikawa T., Katsura Y. The common myelolymphoid progenitor: a key intermediate stage in hemopoiesis generating T and B cells. J Immunol 2002, 169:3519-3525.
    • (2002) J Immunol , vol.169 , pp. 3519-3525
    • Lu, M.1    Kawamoto, H.2    Katsube, Y.3    Ikawa, T.4    Katsura, Y.5
  • 40
    • 0034983283 scopus 로고    scopus 로고
    • Stepwise lineage restriction of progenitors in lympho-myelopoiesis
    • Katsura Y., Kawamoto H. Stepwise lineage restriction of progenitors in lympho-myelopoiesis. Int Rev Immunol 2001, 20:1-20.
    • (2001) Int Rev Immunol , vol.20 , pp. 1-20
    • Katsura, Y.1    Kawamoto, H.2
  • 41
    • 34247092922 scopus 로고    scopus 로고
    • Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
    • Månsson R., Hultquist A., Luc S., et al. Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 2007, 26:407-419.
    • (2007) Immunity , vol.26 , pp. 407-419
    • Månsson, R.1    Hultquist, A.2    Luc, S.3
  • 42
    • 33746208874 scopus 로고    scopus 로고
    • New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors
    • Forsberg E.C., Serwold T., Kogan S., Weissman I.L., Passegue E. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell 2006, 126:415-426.
    • (2006) Cell , vol.126 , pp. 415-426
    • Forsberg, E.C.1    Serwold, T.2    Kogan, S.3    Weissman, I.L.4    Passegue, E.5
  • 43
    • 79959919129 scopus 로고    scopus 로고
    • All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells
    • Boyer S.W., Schroeder A.V., Smith-Berdan S., Forsberg E.C. All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells. Cell Stem Cell 2011, 9:64-73.
    • (2011) Cell Stem Cell , vol.9 , pp. 64-73
    • Boyer, S.W.1    Schroeder, A.V.2    Smith-Berdan, S.3    Forsberg, E.C.4
  • 44
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • Passegue E., Jamieson C.H., Ailles L.E., Weissman I.L. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?. Proc Natl Acad Sci U S A 2003, 100(Suppl 1):11842-11849.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegue, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 45
    • 50849112769 scopus 로고    scopus 로고
    • Delineating the cellular pathways of hematopoietic lineage commitment
    • Luc S., Buza-Vidas N., Jacobsen S.E. Delineating the cellular pathways of hematopoietic lineage commitment. Semin Immunol 2008, 20:213-220.
    • (2008) Semin Immunol , vol.20 , pp. 213-220
    • Luc, S.1    Buza-Vidas, N.2    Jacobsen, S.E.3
  • 46
    • 0021418563 scopus 로고
    • Disparate differentiation in mouse hemopoietic colonies derived from paired progenitors
    • Suda T., Suda J., Ogawa M. Disparate differentiation in mouse hemopoietic colonies derived from paired progenitors. Proc Natl Acad Sci U S A 1984, 81:2520-2524.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 2520-2524
    • Suda, T.1    Suda, J.2    Ogawa, M.3
  • 47
    • 0034613735 scopus 로고    scopus 로고
    • Invitro self-renewal division of hematopoietic stem cells
    • Ema H., Takano H., Sudo K., Nakauchi H. Invitro self-renewal division of hematopoietic stem cells. J Exp Med 2000, 192:1281-1288.
    • (2000) J Exp Med , vol.192 , pp. 1281-1288
    • Ema, H.1    Takano, H.2    Sudo, K.3    Nakauchi, H.4
  • 48
    • 83055161438 scopus 로고    scopus 로고
    • New gene functions in megakaryopoiesis and platelet formation
    • Gieger C., Radhakrishnan A., Cvejic A., et al. New gene functions in megakaryopoiesis and platelet formation. Nature 2011, 480:201-208.
    • (2011) Nature , vol.480 , pp. 201-208
    • Gieger, C.1    Radhakrishnan, A.2    Cvejic, A.3
  • 49
    • 34848883146 scopus 로고    scopus 로고
    • Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
    • Arinobu Y., Mizuno S., Chong Y., et al. Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 2007, 1:416-427.
    • (2007) Cell Stem Cell , vol.1 , pp. 416-427
    • Arinobu, Y.1    Mizuno, S.2    Chong, Y.3
  • 50
    • 70350093398 scopus 로고    scopus 로고
    • Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    • Inlay M.A., Bhattacharya D., Sahoo D., et al. Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev 2009, 23:2376-2381.
    • (2009) Genes Dev , vol.23 , pp. 2376-2381
    • Inlay, M.A.1    Bhattacharya, D.2    Sahoo, D.3
  • 51
    • 34250212481 scopus 로고    scopus 로고
    • Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from
    • Bhandoola A., von Boehmer H., Petrie H.T., Zuniga-Pflucker J.C. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 2007, 26:678-689.
    • (2007) Immunity , vol.26 , pp. 678-689
    • Bhandoola, A.1    von Boehmer, H.2    Petrie, H.T.3    Zuniga-Pflucker, J.C.4
  • 52
    • 43549105168 scopus 로고    scopus 로고
    • The stream of precursors that colonizes the thymus proceeds selectively through the early Tlineage precursor stage of T cell development
    • Benz C., Martins V.C., Radtke F., Bleul C.C. The stream of precursors that colonizes the thymus proceeds selectively through the early Tlineage precursor stage of T cell development. J Exp Med 2008, 205:1187-1199.
    • (2008) J Exp Med , vol.205 , pp. 1187-1199
    • Benz, C.1    Martins, V.C.2    Radtke, F.3    Bleul, C.C.4
  • 53
    • 0030914867 scopus 로고    scopus 로고
    • Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment
    • Bradford G.B., Williams B., Rossi R., Bertoncello I. Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. Exp Hematol 1997, 25:445-453.
    • (1997) Exp Hematol , vol.25 , pp. 445-453
    • Bradford, G.B.1    Williams, B.2    Rossi, R.3    Bertoncello, I.4
  • 54
    • 0032980506 scopus 로고    scopus 로고
    • Invivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
    • Cheshier S.H., Morrison S.J., Liao X., Weissman I.L. Invivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A 1999, 96:3120-3125.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3120-3125
    • Cheshier, S.H.1    Morrison, S.J.2    Liao, X.3    Weissman, I.L.4
  • 55
    • 0034613690 scopus 로고    scopus 로고
    • Age-associated characteristics of murine hematopoietic stem cells
    • Sudo K., Ema H., Morita Y., Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 2000, 192:1273-1280.
    • (2000) J Exp Med , vol.192 , pp. 1273-1280
    • Sudo, K.1    Ema, H.2    Morita, Y.3    Nakauchi, H.4
  • 56
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • Wilson A., Laurenti E., Oser G., et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008, 135:1118-1129.
    • (2008) Cell , vol.135 , pp. 1118-1129
    • Wilson, A.1    Laurenti, E.2    Oser, G.3
  • 57
    • 84880232664 scopus 로고    scopus 로고
    • Heterogeneity in hematopoietic stem cell populations: implications for transplantation
    • Miller P.H., Knapp D.J., Eaves C.J. Heterogeneity in hematopoietic stem cell populations: implications for transplantation. Curr Opin Hematol 2013, 20:257-264.
    • (2013) Curr Opin Hematol , vol.20 , pp. 257-264
    • Miller, P.H.1    Knapp, D.J.2    Eaves, C.J.3
  • 58
    • 0035229584 scopus 로고    scopus 로고
    • Exvivo expansion of human hematopoietic stem cells
    • Nakahata T. Exvivo expansion of human hematopoietic stem cells. Int J Hematol 2001, 73:6-13.
    • (2001) Int J Hematol , vol.73 , pp. 6-13
    • Nakahata, T.1
  • 59
    • 0027263351 scopus 로고
    • Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice
    • Stewart F.M., Crittenden R.B., Lowry P.A., Pearson-White S., Quesenberry P.J. Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice. Blood 1993, 81:2566-2571.
    • (1993) Blood , vol.81 , pp. 2566-2571
    • Stewart, F.M.1    Crittenden, R.B.2    Lowry, P.A.3    Pearson-White, S.4    Quesenberry, P.J.5
  • 60
    • 36448992228 scopus 로고    scopus 로고
    • Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches
    • Czechowicz A., Kraft D., Weissman I.L., Bhattacharya D. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science 2007, 318:1296-1299.
    • (2007) Science , vol.318 , pp. 1296-1299
    • Czechowicz, A.1    Kraft, D.2    Weissman, I.L.3    Bhattacharya, D.4
  • 61
    • 77950981309 scopus 로고    scopus 로고
    • Cellular barcoding tool for clonal analysis in the hematopoietic system
    • Gerrits A., Dykstra B., Kalmykowa O.J., et al. Cellular barcoding tool for clonal analysis in the hematopoietic system. Blood 2010, 115:2610-2618.
    • (2010) Blood , vol.115 , pp. 2610-2618
    • Gerrits, A.1    Dykstra, B.2    Kalmykowa, O.J.3
  • 62
    • 80054719497 scopus 로고    scopus 로고
    • Tracking single hematopoietic stem cells invivo using high-throughput sequencing in conjunction with viral genetic barcoding
    • Lu R., Neff N.F., Quake S.R., Weissman I.L. Tracking single hematopoietic stem cells invivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat Biotechnol 2011, 29:928-933.
    • (2011) Nat Biotechnol , vol.29 , pp. 928-933
    • Lu, R.1    Neff, N.F.2    Quake, S.R.3    Weissman, I.L.4
  • 63
    • 84888212251 scopus 로고    scopus 로고
    • Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice
    • Cheung A.M., Nguyen L.V., Carles A., et al. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice. Blood 2013, 122:3129-3137.
    • (2013) Blood , vol.122 , pp. 3129-3137
    • Cheung, A.M.1    Nguyen, L.V.2    Carles, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.