Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze

Neurodegenerative Diseases

Volumn 13, Issue 2-3, 2014, Pages 192-196

  Hort, J ^a,b   Andel, R ^a,e   Mokrisova, I ^a,b   Gazova, I ^a,b   Amlerova, J ^b   Valis, M ^c   Coulson, E J ^d   Harrison, J ^f,g   Windisch, M ^h   Laczo J ^a,b  

^a ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^b UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g METIS COGNITION LTD   (United Kingdom)

^h NeuroScios GmbH   (Austria)

Author keywords

Alzheimer disease; Donepezil; Human analog of the Morris water maze; Morris water maze; Spatial navigation

Indexed keywords

DONEPEZIL;

AGED; ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC TRANSMISSION; CLINICAL ARTICLE; COMPUTER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFECT; FEMALE; HUMAN; HUMAN VARIANT OF MORRIS WATER MAZE TEST; MALE; MINI MENTAL STATE EXAMINATION; MORRIS WATER MAZE TEST; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECALL; SPATIAL ORIENTATION; TASK PERFORMANCE; COMPUTERIZED HUMAN MORRIS WATER MAZE TEST; CONFERENCE PAPER; DRUG RESPONSE; DSM-IV-TR; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING;

AGED; ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; COMPUTERS; FEMALE; HUMANS; INDANS; MALE; NEUROPSYCHOLOGICAL TESTS; PILOT PROJECTS; PIPERIDINES; SPATIAL BEHAVIOR;

EID: 84896724504     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000355517     Document Type: Article

References (14)

1. Green R, Schneider L, Amato D, Beelen A, Wilcock G, Swabb E, Zavitz K, Tarenflurbil Phase 3 Study Group: Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 2009; 302: 2557-2564.
2. Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM: Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci 2007; 8: 54.
3. Morris RG, Garrud P, Rawlins JN, O'Keefe J: Place navigation impaired in rats with hippocampal lesions. Nature 1982; 297: 681-683.
4. Hort J, Laczó J, Vyhnálek M, Bojar M, Bureš J, Vlček K: Spatial navigation deficit in amnestic mild cognitive impairment. Proc Natl Acad Sci USA 2007; 104: 4042-4047.
5. Hort J, Glosová L, Vyhnálek M, et al: The liquor tau protein and beta amyloid in Alzheimer's disease. Cesk Slov Neurol N 2007; 70: 30-36.
6. Laczó J, Vlček K, Vyhnálek M, Vajnerová O, Ort M, Holmerová I, Tolar M, Andel R, Bojar M, Hort J: Spatial navigation testing discriminates two types of amnestic mild cognitive impairment. Behav Brain Res 2009; 202: 252-259.
7. Laczó J, Andel R, Vyhnálek M, Vlček K, Magerová H, Varjassyová A, Nedelská Z, Gažová I, Bojar M, Sheardová K, Hort J: From Morris Water Maze to computer tests in the prediction of Alzheimer's disease. Neurodegener Dis 2012; 10: 153-157.
8. Laczó J, Andel R, Vlček K, Macoška V, Vyhnálek M, Tolar M, Bojar M, Hort J: Spatial navigation and APOE in amnestic mild cognitive impairment. Neurodegener Dis 2011; 8: 169-177.
9. Nedelská Z, Andel R, Laczó J, Vlček K, Hořínek D, Lisý J, Sheardová K, Bureš J, Hort J: Spatial navigation impairment is proportional to right hippocampal volume. Proc Natl Acad Sci USA 2012; 109: 2590-2594.
10. Berger-Sweeney J, Stearns N, Murg S, Floerke-Nashner L, Lappi D, Baxter M: Selective immunolesions of cholinergic neurons in mice: effects on neuroanatomy, neurochemistry, and behavior. J Neurosci 2001; 21: 8164-8173.
11. Grön G, Brandenburg I, Wunderlich A, Riepe M: Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis. Neurobiol Aging 2006; 27: 78-87.
12. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
13. Birks J, Harvey R: Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev 2006;1:CD001190.
14. Laczó J, Andel R, Vlček K, Vyhnálek M, Gažová I, Nedelská Z, Mokrišová I, Hynčicová E, Literáková E, Sheardová K, Wagner M, Coulson EJ, Hort J: Spatial navigation in the real world is a separate cognitive domain: study on cognitively normal elderly and mild cognitive impairment. Neurodegener Dis 2013, in press.