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Volumn 34, Issue 3, 2014, Pages 495-501

Rivaroxaban does not increase hemorrhage after thrombolysis in experimental ischemic stroke

Author keywords

animal models; antithrombotics; blood brain barrier; brain ischemia; intracerebral hemorrhage; thrombolysis

Indexed keywords

ALTEPLASE; EVANS BLUE; HEMOGLOBIN; RIVAROXABAN; WARFARIN;

EID: 84896720180     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.226     Document Type: Article
Times cited : (48)

References (42)
  • 4
    • 84869114866 scopus 로고    scopus 로고
    • Antithrombotic therapy for stroke prevention in non-valvular atrial fibrillation
    • Alberts MJ, Eikelboom JW, Hankey GJ. Antithrombotic therapy for stroke prevention in non-valvular atrial fibrillation. Lancet Neurol 2012; 11: 1066-1081.
    • (2012) Lancet Neurol , vol.11 , pp. 1066-1081
    • Alberts, M.J.1    Eikelboom, J.W.2    Hankey, G.J.3
  • 5
    • 84878260361 scopus 로고    scopus 로고
    • Recommendations for the emergency management of complications associated with the new direct oral anticoagulants (DOACs), apixaban, dabigatran and rivaroxaban
    • Steiner T, Bo?hm M, Dichgans M, Diener H, Ell C, Endres M et al. Recommendations for the emergency management of complications associated with the new direct oral anticoagulants (DOACs), apixaban, dabigatran and rivaroxaban. Clin Res Cardiol 2013; 102: 399-412.
    • (2013) Clin Res Cardiol , vol.102 , pp. 399-412
    • Steiner, T.1    Bohm, M.2    Dichgans, M.3    Diener, H.4    Ell, C.5    Endres, M.6
  • 6
    • 84879014439 scopus 로고    scopus 로고
    • Treatment of acute ischaemic stroke with thrombolysis or thrombectomy in patients receiving antithrombotic treatment
    • Diener H, Foerch C, Riess H, Ro? ther J, Schroth G, Weber R. Treatment of acute ischaemic stroke with thrombolysis or thrombectomy in patients receiving antithrombotic treatment. Lancet Neurol 2013; 12: 677-688.
    • (2013) Lancet Neurol , vol.12 , pp. 677-688
    • Diener, H.1    Foerch, C.2    Riess, H.3    Rother, J.4    Schroth, G.5    Weber, R.6
  • 7
    • 41249092747 scopus 로고    scopus 로고
    • The American academy of neurology affirms the value of this guideline as an educational tool for neurologists
    • Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups
    • Adams HP, del Zoppo GJ, Alberts MJ, Bhatt DL, Brass L, Furlan A et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation 2007; 115: e478-e534.
    • (2007) Circulation , vol.115
    • Adams, H.P.1    Del Zoppo, G.J.2    Alberts, M.J.3    Bhatt, D.L.4    Brass, L.5    Furlan, A.6
  • 8
  • 9
    • 77952112006 scopus 로고    scopus 로고
    • Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
    • Lees KR, Bluhmki E, Kummer R, von, Brott TG, Toni D, Grotta JC et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010; 375: 1695-1703.
    • (2010) Lancet , vol.375 , pp. 1695-1703
    • Lees, K.R.1    Bluhmki, E.2    Kummer, R.3    Von Brott, T.G.4    Toni, D.5    Grotta, J.C.6
  • 10
    • 80054805311 scopus 로고    scopus 로고
    • Warfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: Therapeutic potential of PCC
    • Pfeilschifter W, Spitzer D, Pfeilschifter J, Steinmetz H, Foerch C, Borlongan CV. Warfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: therapeutic potential of PCC. PLoS ONE 2011; 6: e26087.
    • (2011) PLoS ONE , vol.6
    • Pfeilschifter, W.1    Spitzer, D.2    Pfeilschifter, J.3    Steinmetz, H.4    Foerch, C.5    Borlongan, C.V.6
  • 11
    • 84856211216 scopus 로고    scopus 로고
    • Rapid reversal of anticoagulation prevents excessive secondary hemorrhage after thrombolysis in a thromboembolic model in rats
    • Sun L, Zhou W, Ploen R, Heiland S, Zorn M, Veltkamp R. Rapid reversal of anticoagulation prevents excessive secondary hemorrhage after thrombolysis in a thromboembolic model in rats. Stroke 2011; 42: 3524-3529.
    • (2011) Stroke , vol.42 , pp. 3524-3529
    • Sun, L.1    Zhou, W.2    Ploen, R.3    Heiland, S.4    Zorn, M.5    Veltkamp, R.6
  • 12
    • 84863603095 scopus 로고    scopus 로고
    • Subtherapeutic warfarin therapy entails an increased bleeding risk after stroke thrombolysis
    • Ruecker M, Matosevic B, Willeit P, Kirchmayr M, Zangerle A, Knoflach M et al. Subtherapeutic warfarin therapy entails an increased bleeding risk after stroke thrombolysis. Neurology 2012; 79: 31-38.
    • (2012) Neurology , vol.79 , pp. 31-38
    • Ruecker, M.1    Matosevic, B.2    Willeit, P.3    Kirchmayr, M.4    Zangerle, A.5    Knoflach, M.6
  • 13
    • 84862858987 scopus 로고    scopus 로고
    • Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator
    • Xian Y, Liang L, Smith EE, Schwamm LH, Reeves MJ, Olson DM et al. Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator. J Am Med Ass 2012; 307: 2600-2608.
    • (2012) J Am Med Ass , vol.307 , pp. 2600-2608
    • Xian, Y.1    Liang, L.2    Smith, E.E.3    Schwamm, L.H.4    Reeves, M.J.5    Olson, D.M.6
  • 15
    • 82355184607 scopus 로고    scopus 로고
    • Fibrinolytic treatment of acute ischemic stroke for patients on new oral anticoagulant drugs
    • Dempfle C, Hennerici MG. Fibrinolytic treatment of acute ischemic stroke for patients on new oral anticoagulant drugs. Cerebrovasc Dis 2011; 32: 616-619.
    • (2011) Cerebrovasc Dis , vol.32 , pp. 616-619
    • Dempfle, C.1    Hennerici, M.G.2
  • 16
    • 22844442726 scopus 로고    scopus 로고
    • Vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-An oral, direct Factor Xa inhibitor
    • Perzborn E, Strassburger J, Wilmen A, Pohlmann J, Roehrig S, Schlemmer K et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-An oral, direct Factor Xa inhibitor. J Thromb Haemost 2005; 3: 514-521.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3    Pohlmann, J.4    Roehrig, S.5    Schlemmer, K.6
  • 17
    • 84876288671 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban
    • Zhou W, Zorn M, Nawroth P, Bu? tehorn U, Perzborn E, Heitmeier S et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban. Stroke 2013; 44: 771-778.
    • (2013) Stroke , vol.44 , pp. 771-778
    • Zhou, W.1    Zorn, M.2    Nawroth, P.3    Butehorn, U.4    Perzborn, E.5    Heitmeier, S.6
  • 18
    • 79451472446 scopus 로고    scopus 로고
    • Comparative effectiveness of hemostatic therapy in experimental warfarin-Associated intracerebral hemorrhage
    • Illanes S, Zhou W, Schwarting S, Heiland S, Veltkamp R. Comparative effectiveness of hemostatic therapy in experimental warfarin-Associated intracerebral hemorrhage. Stroke 2011; 42: 191-195.
    • (2011) Stroke , vol.42 , pp. 191-195
    • Illanes, S.1    Zhou, W.2    Schwarting, S.3    Heiland, S.4    Veltkamp, R.5
  • 19
    • 70350560778 scopus 로고    scopus 로고
    • Point-ofcare international normalized ratio testing accelerates thrombolysis in patients with acute ischemic stroke using oral anticoagulants
    • Rizos T, Herweh C, Jenetzky E, Lichy C, Ringleb PA, Hacke W et al. Point-ofcare international normalized ratio testing accelerates thrombolysis in patients with acute ischemic stroke using oral anticoagulants. Stroke 2009; 40: 3547-3551.
    • (2009) Stroke , vol.40 , pp. 3547-3551
    • Rizos, T.1    Herweh, C.2    Jenetzky, E.3    Lichy, C.4    Ringleb, P.A.5    Hacke, W.6
  • 21
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20: 84-91.
    • (1989) Stroke , vol.20 , pp. 84-91
    • Longa, E.Z.1    Weinstein, P.R.2    Carlson, S.3    Cummins, R.4
  • 22
    • 84879621987 scopus 로고    scopus 로고
    • Anticoagulation with dabigatran does not increase secondary intracerebral haemorrhage after thrombolysis in experimental cerebral ischaemia
    • Sun L, Zhou W, Ploen R, Zorn M, Veltkamp R. Anticoagulation with dabigatran does not increase secondary intracerebral haemorrhage after thrombolysis in experimental cerebral ischaemia. Thromb Haemost 2013; 110: 153-161.
    • (2013) Thromb Haemost , vol.110 , pp. 153-161
    • Sun, L.1    Zhou, W.2    Ploen, R.3    Zorn, M.4    Veltkamp, R.5
  • 23
    • 0036158760 scopus 로고    scopus 로고
    • Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke
    • Toomey JR, Valocik RE, Koster PF, Gabriel MA, McVey M, Hart TK et al. Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke. Stroke 2002; 33: 578-585.
    • (2002) Stroke , vol.33 , pp. 578-585
    • Toomey, J.R.1    Valocik, R.E.2    Koster, P.F.3    Gabriel, M.A.4    McVey, M.5    Hart, T.K.6
  • 24
    • 78651072997 scopus 로고    scopus 로고
    • A translationally relevant thromboembolic stroke model for the study of secondary hemorrhage after thrombolysis in rats
    • Sun L, Zhou W, Heiland S, Marti HH, Veltkamp R. A translationally relevant thromboembolic stroke model for the study of secondary hemorrhage after thrombolysis in rats. Brain Res 2011; 1368: 346-354.
    • (2011) Brain Res , vol.1368 , pp. 346-354
    • Sun, L.1    Zhou, W.2    Heiland, S.3    Marti, H.H.4    Veltkamp, R.5
  • 25
    • 0030710120 scopus 로고    scopus 로고
    • Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice
    • Choudhri TF, Hoh BL, Solomon RA, Connolly ES, Pinsky DJ. Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice. Stroke 1997; 28: 2296-2302.
    • (1997) Stroke , vol.28 , pp. 2296-2302
    • Choudhri, T.F.1    Hoh, B.L.2    Solomon, R.A.3    Connolly, E.S.4    Pinsky, D.J.5
  • 26
    • 0023856405 scopus 로고
    • Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence
    • Uyama O, Okamura N, Yanase M, Narita M, Kawabata K, Sugita M. Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence. J Cereb Blood Flow Metab 1988; 8: 282-284.
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 282-284
    • Uyama, O.1    Okamura, N.2    Yanase, M.3    Narita, M.4    Kawabata, K.5    Sugita, M.6
  • 27
    • 0030580410 scopus 로고    scopus 로고
    • Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats
    • Belayev L, Busto R, Zhao W, Ginsberg MD. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res 1996; 739: 88-96.
    • (1996) Brain Res , vol.739 , pp. 88-96
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 28
    • 23244437437 scopus 로고    scopus 로고
    • Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia
    • Veltkamp R, Siebing DA, Sun L, Heiland S, Bieber K, Marti HH et al. Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia. Stroke 2005; 36: 1679-1683.
    • (2005) Stroke , vol.36 , pp. 1679-1683
    • Veltkamp, R.1    Siebing, D.A.2    Sun, L.3    Heiland, S.4    Bieber, K.5    Marti, H.H.6
  • 29
  • 30
    • 84864213148 scopus 로고    scopus 로고
    • No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke
    • Bohmann F, Mirceska A, Pfeilschifter J, Lindhoff-Last E, Steinmetz H, Foerch C et al. No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke. PLoS ONE 2012; 7: e40804.
    • (2012) PLoS ONE , vol.7
    • Bohmann, F.1    Mirceska, A.2    Pfeilschifter, J.3    Lindhoff-Last, E.4    Steinmetz, H.5    Foerch, C.6
  • 31
    • 84870930023 scopus 로고    scopus 로고
    • Secondary intracerebral hemorrhage due to early initiation of oral anticoagulation after ischemic stroke: An experimental study in mice
    • Gliem M, Hermsen D, van Rooijen N, Hartung H, Jander S. Secondary intracerebral hemorrhage due to early initiation of oral anticoagulation after ischemic stroke: an experimental study in mice. Stroke 2012; 43: 3352-3357.
    • (2012) Stroke , vol.43 , pp. 3352-3357
    • Gliem, M.1    Hermsen, D.2    Van Rooijen, N.3    Hartung, H.4    Jander, S.5
  • 32
    • 80052485992 scopus 로고    scopus 로고
    • Rivaroxaban: Population pharmacokinetic analyses in patients treated for acute deepvein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention
    • Mueck W, Lensing AW, Agnelli G, Decousus H, Prandoni P, Misselwitz F. Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deepvein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention. Clin Pharmacokinet 2011; 50: 675-686.
    • (2011) Clin Pharmacokinet , vol.50 , pp. 675-686
    • Mueck, W.1    Lensing, A.W.2    Agnelli, G.3    Decousus, H.4    Prandoni, P.5    Misselwitz, F.6
  • 33
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005; 78: 412-421.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 34
    • 84862146631 scopus 로고    scopus 로고
    • Report of the Subcommittee of Control of Anticoagulation on the determination of the anticoagulant effects of rivaroxaban
    • Harenberg J, Marx S, Weiss C, Kra?mer R, Samama MM, Schulman S. Report of the Subcommittee of Control of Anticoagulation on the determination of the anticoagulant effects of rivaroxaban. J Thromb Haemost 2012; 10: 1433-1436.
    • (2012) J Thromb Haemost , vol.10 , pp. 1433-1436
    • Harenberg, J.1    Marx, S.2    Weiss, C.3    Kramer, R.4    Samama, M.M.5    Schulman, S.6
  • 35
    • 7644227043 scopus 로고    scopus 로고
    • Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke
    • Wang X, Tsuji K, Lee S, Ning M, Furie KL, Buchan AM et al. Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke 2004; 35: 2726-2730.
    • (2004) Stroke , vol.35 , pp. 2726-2730
    • Wang, X.1    Tsuji, K.2    Lee, S.3    Ning, M.4    Furie, K.L.5    Buchan, A.M.6
  • 36
    • 0035881168 scopus 로고    scopus 로고
    • FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834
    • McLean K, Schirm S, Johns A, Morser J, Light DR. FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834. Thromb Res 2001; 103: 281-297.
    • (2001) Thromb Res , vol.103 , pp. 281-297
    • McLean, K.1    Schirm, S.2    Johns, A.3    Morser, J.4    Light, D.R.5
  • 37
    • 1642279517 scopus 로고    scopus 로고
    • Protease-Activated receptors: Contribution to physiology and disease
    • Ossovskaya VS, Bunnett NW. Protease-Activated receptors: contribution to physiology and disease. Physiol Rev 2004; 84: 579-621.
    • (2004) Physiol Rev , vol.84 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 38
    • 84887099656 scopus 로고    scopus 로고
    • Coagulation factor Xa induces an inflammatory signalling by activation of proteaseactivated receptors in human atrial tissue
    • Bukowska A, Zacharias I, Weinert S, Skopp K, Hartmann C, Huth C et al. Coagulation factor Xa induces an inflammatory signalling by activation of proteaseactivated receptors in human atrial tissue. Eur J Pharmacol 2013; 718: 114-123.
    • (2013) Eur J Pharmacol , vol.718 , pp. 114-123
    • Bukowska, A.1    Zacharias, I.2    Weinert, S.3    Skopp, K.4    Hartmann, C.5    Huth, C.6
  • 39
    • 79953161072 scopus 로고    scopus 로고
    • Cytoprotective protein C pathways and implications for stroke and neurological disorders
    • Zlokovic BV, Griffin JH. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci 2011; 34: 198-209.
    • (2011) Trends Neurosci , vol.34 , pp. 198-209
    • Zlokovic, B.V.1    Griffin, J.H.2
  • 40
    • 79953092222 scopus 로고    scopus 로고
    • Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
    • Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT et al. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 2011; 117: 3199-3208.
    • (2011) Blood , vol.117 , pp. 3199-3208
    • Sen, P.1    Gopalakrishnan, R.2    Kothari, H.3    Keshava, S.4    Clark, C.A.5    Esmon, C.T.6
  • 41
    • 33750704292 scopus 로고    scopus 로고
    • Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage
    • Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med 2006; 12: 1278-1285.
    • (2006) Nat Med , vol.12 , pp. 1278-1285
    • Cheng, T.1    Petraglia, A.L.2    Li, Z.3    Thiyagarajan, M.4    Zhong, Z.5    Wu, Z.6
  • 42
    • 84856214360 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    • Zhou W, Schwarting S, Illanes S, Liesz A, Middelhoff M, Zorn M et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran. Stroke 2011; 42: 3594-3599.
    • (2011) Stroke , vol.42 , pp. 3594-3599
    • Zhou, W.1    Schwarting, S.2    Illanes, S.3    Liesz, A.4    Middelhoff, M.5    Zorn, M.6


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