메뉴 건너뛰기




Volumn 109, Issue 4, 2014, Pages 547-557

Efficacy of stimulants for cognitive enhancement in non-attention deficit hyperactivity disorder youth: A systematic review

Author keywords

Abuse; Cognitive; Enhancement; Healthy; Misuse; Neurocognitive; Non ADHD; Stimulants; Youth.

Indexed keywords

AMPHETAMINE; BENZHYDRYL DERIVATIVE; CENTRAL STIMULANT AGENT; METHYLPHENIDATE; MODAFINIL; NOOTROPIC AGENT;

EID: 84896716363     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/add.12460     Document Type: Review
Times cited : (77)

References (46)
  • 1
    • 84896698492 scopus 로고    scopus 로고
    • Monitoring the Future national results on adolescent drug use: overview of key findings, 2011. Ann Arbor, MI: The University of Michigan, Institute for Social Research;.
    • Johnston L. D., O'Malley P. M., Bachman J. G., Schulenberg J. E. Monitoring the Future national results on adolescent drug use: overview of key findings, 2011. Ann Arbor, MI: The University of Michigan, Institute for Social Research; 2012.
    • (2012)
    • Johnston, L.D.1    O'Malley, P.M.2    Bachman, J.G.3    Schulenberg, J.E.4
  • 2
    • 84896735691 scopus 로고    scopus 로고
    • National Institute on Drug Abuse (NIDA). Topics in Brief: Prescription Drug Abuse. Bethesda, MD: NIDA;.
    • National Institute on Drug Abuse (NIDA). Topics in Brief: Prescription Drug Abuse. Bethesda, MD: NIDA; 2011.
    • (2011)
  • 3
    • 84896721108 scopus 로고    scopus 로고
    • Substance Abuse and Mental Health Services (SAMHSA). Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. Rockville, MD: SAMHSA;.
    • Substance Abuse and Mental Health Services (SAMHSA). Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. Rockville, MD: SAMHSA; 2011.
    • (2011)
  • 4
    • 44449151560 scopus 로고    scopus 로고
    • Increasing use of stimulants warns of potential abuse
    • Swanson J. M., Volkow N. D. Increasing use of stimulants warns of potential abuse. Nature 2008; 453: 586.
    • (2008) Nature , vol.453 , pp. 586
    • Swanson, J.M.1    Volkow, N.D.2
  • 6
    • 80052196380 scopus 로고    scopus 로고
    • Contrast of medical and nonmedical use of stimulant drugs, basis for the distinction, and risk of addiction: comment on Smith and Farah (2011)
    • Swanson J. M., Wigal T. L., Volkow N. D. Contrast of medical and nonmedical use of stimulant drugs, basis for the distinction, and risk of addiction: comment on Smith and Farah (2011). Psychol Bull 2011; 137: 742-748.
    • (2011) Psychol Bull , vol.137 , pp. 742-748
    • Swanson, J.M.1    Wigal, T.L.2    Volkow, N.D.3
  • 7
    • 84879942973 scopus 로고    scopus 로고
    • Risky rise of the good-grade pill
    • New York Times, 10 June 2012. Available at (accessed 16 January 2014) (Archived at on 16 January 2014).
    • Schwarz A. Risky rise of the good-grade pill. New York Times, 10 June 2012. Available at: http://www.nytimes.com/2012/06/10/education/seeking-academic-edge-teenagers-abuse-stimulants.html?pagewanted=all (accessed 16 January 2014) (Archived at http://www.webcitation.org/6Mg2VI375 on 16 January 2014).
    • Schwarz, A.1
  • 8
    • 84878982014 scopus 로고    scopus 로고
    • Drowned in a stream of prescriptions
    • New York Times, 3 February 2013. Available at, accessed 16 January 2014) (Archived at, on 16 January 2014
    • Schwarz A. Drowned in a stream of prescriptions. New York Times, 3 February 2013. Available at: http://www.nytimes.com/2013/02/03/us/concerns-about-adhd-practices-and-amphetamine-addiction.html (accessed 16 January 2014) (Archived at http://www.webcitation.org/6Mg2lKXDA on 16 January 2014).
    • Schwarz, A.1
  • 9
    • 84878340718 scopus 로고    scopus 로고
    • Attention disorder or not, pills to help in school
    • New York Times, 9 October 2012. Available at, accessed 16 January 2014) (Archived at, on 16 January 2014
    • Schwarz A. Attention disorder or not, pills to help in school. New York Times, 9 October 2012. Available at: http://www.nytimes.com/2012/10/09/health/attention-disorder-or-not-children-prescribed-pills-to-help-in-school.html?pagewanted=all (accessed 16 January 2014) (Archived at http://www.webcitation.org/6Mg2sfdv4 on 16 January 2014).
    • Schwarz, A.1
  • 12
    • 70349929349 scopus 로고    scopus 로고
    • Cognitive enhancement: methods, ethics, regulatory challenges
    • Bostrom N., Sandberg A. Cognitive enhancement: methods, ethics, regulatory challenges. Sci Eng Ethics 2009; 15: 311-341.
    • (2009) Sci Eng Ethics , vol.15 , pp. 311-341
    • Bostrom, N.1    Sandberg, A.2
  • 13
    • 84863996706 scopus 로고    scopus 로고
    • Cognitive neuroenhancement: false assumptions in the ethical debate
    • Heinz A., Kipke R., Heimann H., Wiesing U. Cognitive neuroenhancement: false assumptions in the ethical debate. J Med Ethics 2012; 38: 372-375.
    • (2012) J Med Ethics , vol.38 , pp. 372-375
    • Heinz, A.1    Kipke, R.2    Heimann, H.3    Wiesing, U.4
  • 14
    • 33749454756 scopus 로고    scopus 로고
    • Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration
    • Teter C. J., McCabe S. E., LaGrange K., Cranford J. A., Boyd C. J. Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration. Pharmacotherapy 2006; 26: 1501-1510.
    • (2006) Pharmacotherapy , vol.26 , pp. 1501-1510
    • Teter, C.J.1    McCabe, S.E.2    LaGrange, K.3    Cranford, J.A.4    Boyd, C.J.5
  • 15
    • 19344369236 scopus 로고    scopus 로고
    • Prevalence and motives for illicit use of prescription stimulants in an undergraduate student sample
    • Teter C. J., McCabe S. E., Cranford J. A., Boyd C. J., Guthrie S. K. Prevalence and motives for illicit use of prescription stimulants in an undergraduate student sample. J Am Coll Health 2005; 53: 253-262.
    • (2005) J Am Coll Health , vol.53 , pp. 253-262
    • Teter, C.J.1    McCabe, S.E.2    Cranford, J.A.3    Boyd, C.J.4    Guthrie, S.K.5
  • 16
    • 1542267887 scopus 로고    scopus 로고
    • The placebo effect: dissolving the expectancy versus conditioning debate
    • Stewart-Williams S., Podd J. The placebo effect: dissolving the expectancy versus conditioning debate. Psychol Bull 2004; 130: 324-340.
    • (2004) Psychol Bull , vol.130 , pp. 324-340
    • Stewart-Williams, S.1    Podd, J.2
  • 17
    • 0029953346 scopus 로고    scopus 로고
    • Interaction of expectancy and the pharmacological effects of d-amphetamine: subjective effects and self-administration
    • Mitchell S. H., Laurent C. L., de Wit H. Interaction of expectancy and the pharmacological effects of d-amphetamine: subjective effects and self-administration. Psychopharmacology (Berl) 1996; 125: 371-378.
    • (1996) Psychopharmacology (Berl) , vol.125 , pp. 371-378
    • Mitchell, S.H.1    Laurent, C.L.2    de Wit, H.3
  • 18
    • 10244239333 scopus 로고    scopus 로고
    • Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD
    • Volkow N. D., Swanson J. M. Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry 2003; 160: 1909-1918.
    • (2003) Am J Psychiatry , vol.160 , pp. 1909-1918
    • Volkow, N.D.1    Swanson, J.M.2
  • 19
    • 83755219970 scopus 로고    scopus 로고
    • Expectation to receive methylphenidate enhances subjective arousal but not cognitive performance
    • Looby A., Earleywine M. Expectation to receive methylphenidate enhances subjective arousal but not cognitive performance. Exp Clin Psychopharmacol 2011; 19: 433-444.
    • (2011) Exp Clin Psychopharmacol , vol.19 , pp. 433-444
    • Looby, A.1    Earleywine, M.2
  • 20
    • 0027536612 scopus 로고
    • Stimulant drugs and vigilance performance: a review
    • Koelega H. S. Stimulant drugs and vigilance performance: a review. Psychopharmacology (Berl) 1993; 111: 1-16.
    • (1993) Psychopharmacology (Berl) , vol.111 , pp. 1-16
    • Koelega, H.S.1
  • 21
    • 77954085550 scopus 로고    scopus 로고
    • What are the cognitive effects of stimulant medications? Emphasis on adults with attention-deficit/hyperactivity disorder (ADHD)
    • Advokat C. What are the cognitive effects of stimulant medications? Emphasis on adults with attention-deficit/hyperactivity disorder (ADHD). Neurosci Biobehav Rev 2010; 34: 1256-1266.
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 1256-1266
    • Advokat, C.1
  • 23
    • 67650097228 scopus 로고    scopus 로고
    • Improving introspection to inform free will regarding the choice by healthy individuals to use or not use cognitive enhancing drugs
    • Thaler D. S. Improving introspection to inform free will regarding the choice by healthy individuals to use or not use cognitive enhancing drugs. Harm Reduct J 2009; 6: 10.
    • (2009) Harm Reduct J , vol.6 , pp. 10
    • Thaler, D.S.1
  • 26
    • 0030755899 scopus 로고    scopus 로고
    • Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo
    • Baranski J. V., Pigeau R. A. Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo. J Sleep Res 1997; 6: 84-91.
    • (1997) J Sleep Res , vol.6 , pp. 84-91
    • Baranski, J.V.1    Pigeau, R.A.2
  • 27
    • 4243109691 scopus 로고    scopus 로고
    • Effects of modafinil on cognitive and meta-cognitive performance
    • Baranski J. V., Pigeau R., Dinich P., Jacobs I. Effects of modafinil on cognitive and meta-cognitive performance. Hum Psychopharmacol 2004; 19: 323-332.
    • (2004) Hum Psychopharmacol , vol.19 , pp. 323-332
    • Baranski, J.V.1    Pigeau, R.2    Dinich, P.3    Jacobs, I.4
  • 28
    • 0033923478 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study
    • Caldwell J. A. Jr, Caldwell J. L., Smythe N. K. III, Hall K. K. A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology (Berl) 2000; 150: 272-282.
    • (2000) Psychopharmacology (Berl) , vol.150 , pp. 272-282
    • Caldwell Jr., J.A.1    Caldwell, J.L.2    Smythe III, N.K.3    Hall, K.K.4
  • 29
    • 62549111720 scopus 로고    scopus 로고
    • Sustaining executive functions during sleep deprivation: a comparison of caffeine, dextroamphetamine, and modafinil
    • Killgore W. D., Kahn-Greene E. T., Grugle N. L., Killgore D. B., Balkin T. J. Sustaining executive functions during sleep deprivation: a comparison of caffeine, dextroamphetamine, and modafinil. Sleep 2009; 32: 205-216.
    • (2009) Sleep , vol.32 , pp. 205-216
    • Killgore, W.D.1    Kahn-Greene, E.T.2    Grugle, N.L.3    Killgore, D.B.4    Balkin, T.J.5
  • 31
    • 0347627802 scopus 로고    scopus 로고
    • Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder
    • Aron A. R., Dowson J. H., Sahakian B. J., Robbins T. W. Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry 2003; 54: 1465-1468.
    • (2003) Biol Psychiatry , vol.54 , pp. 1465-1468
    • Aron, A.R.1    Dowson, J.H.2    Sahakian, B.J.3    Robbins, T.W.4
  • 33
    • 2442594676 scopus 로고    scopus 로고
    • Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour
    • Rogers R. D., Blackshaw A. J., Middleton H. C., Matthews K., Hawtin K., Crowley C. etal. Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour. Psychopharmacology (Berl) 1999; 146: 482-491.
    • (1999) Psychopharmacology (Berl) , vol.146 , pp. 482-491
    • Rogers, R.D.1    Blackshaw, A.J.2    Middleton, H.C.3    Matthews, K.4    Hawtin, K.5    Crowley, C.6
  • 35
    • 85047670409 scopus 로고    scopus 로고
    • The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity
    • Holroyd C. B., Coles M. G. The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Psychol Rev 2002; 109: 679-709.
    • (2002) Psychol Rev , vol.109 , pp. 679-709
    • Holroyd, C.B.1    Coles, M.G.2
  • 36
    • 84862682516 scopus 로고    scopus 로고
    • Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers
    • Linssen A. M., Vuurman E. F., Sambeth A., Riedel W. J. Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers. Psychopharmacology (Berl) 2012; 221: 611-619.
    • (2012) Psychopharmacology (Berl) , vol.221 , pp. 611-619
    • Linssen, A.M.1    Vuurman, E.F.2    Sambeth, A.3    Riedel, W.J.4
  • 40
    • 59449103091 scopus 로고    scopus 로고
    • When we enhance cognition with dextroamphetamine, do we sacrifice creativity? A preliminary study
    • Farah M. J., Haimm C., Sankoorikal G., Smith M. E., Chatterjee A. When we enhance cognition with dextroamphetamine, do we sacrifice creativity? A preliminary study. Psychopharmacology (Berl) 2009; 202: 541-547.
    • (2009) Psychopharmacology (Berl) , vol.202 , pp. 541-547
    • Farah, M.J.1    Haimm, C.2    Sankoorikal, G.3    Smith, M.E.4    Chatterjee, A.5
  • 41
    • 84866406718 scopus 로고    scopus 로고
    • Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people
    • Ilieva I., Boland J., Farah M. J. Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people. Neuropharmacology 2013; 64: 496-505.
    • (2013) Neuropharmacology , vol.64 , pp. 496-505
    • Ilieva, I.1    Boland, J.2    Farah, M.J.3
  • 42
    • 0037947438 scopus 로고    scopus 로고
    • Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    • Mattay V. S., Goldberg T. E., Fera F., Hariri A. R., Tessitore A., Egan M. F. etal. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 2003; 100: 6186-6191.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6186-6191
    • Mattay, V.S.1    Goldberg, T.E.2    Fera, F.3    Hariri, A.R.4    Tessitore, A.5    Egan, M.F.6
  • 44
    • 58049211851 scopus 로고    scopus 로고
    • Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration
    • Izquierdo I., Bevilaqua L. R., Rossato J. I., Lima R. H., Medina J. H., Cammarota M. Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration. Proc Natl Acad Sci U S A 2008; 105: 19504-19507.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19504-19507
    • Izquierdo, I.1    Bevilaqua, L.R.2    Rossato, J.I.3    Lima, R.H.4    Medina, J.H.5    Cammarota, M.6
  • 45
    • 0029560394 scopus 로고
    • Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature
    • Pigeau R., Naitoh P., Buguet A., McCann C., Baranski J., Taylor M. etal. Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res 1995; 4: 212-228.
    • (1995) J Sleep Res , vol.4 , pp. 212-228
    • Pigeau, R.1    Naitoh, P.2    Buguet, A.3    McCann, C.4    Baranski, J.5    Taylor, M.6
  • 46
    • 80052197522 scopus 로고    scopus 로고
    • Are prescription stimulants 'smart pills'? The epidemiology and cognitive neuroscience of prescription stimulant use by normal healthy individuals
    • Smith M. E., Farah M. J. Are prescription stimulants 'smart pills'? The epidemiology and cognitive neuroscience of prescription stimulant use by normal healthy individuals. Psychol Bull 2011; 137: 717-741.
    • (2011) Psychol Bull , vol.137 , pp. 717-741
    • Smith, M.E.1    Farah, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.