Pain identifies squamous cell carcinoma in organ transplant recipients: The SCOPE-ITSCC PAIN study

American Journal of Transplantation

Volumn 14, Issue 3, 2014, Pages 668-676

  Bouwes Bavinck, J N ^a   Harwood, C A ^b   Genders, R E ^a   Wisgerhof, H C ^a   Plasmeijer, E I ^a   Mitchell, L ^b   Olasz, E B ^c   Mosel, D D ^c   Pokorney, M S ^c   Serra, A L ^d   Feldmeyer, L ^d   Baumann Conzett, K ^d   Piaserico, S ^e   Belloni Fortina, A ^e   Jahn, K ^f   Geusau, A ^f   Gerritsen, M J P ^g   Seckin D ^h   Gulec A T ^h   Cetkovska P ⁱ   Ricar, J ⁱ   Imko Walczuk, B ^j   Proby, C M ^b,k   Hofbauer, G F L ^d   more..

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e UNIVERSITY OF PADOVA   (Italy)

^f Universitatsklinik fur Dermatologie   (Austria)

^g RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^h BASKENT UNIVERSITY   (Turkey)

ⁱ CHARLES UNIVERSITY   (Czech Republic)

^j Department of Dermatology   (Poland)

^k UNIVERSITY OF DUNDEE   (United Kingdom)

more..

Author keywords

Adverse effect; pain; squamous cell carcinoma

Indexed keywords

ADULT; ARTICLE; CANCER DIAGNOSIS; FEMALE; GRAFT RECIPIENT; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ORGAN TRANSPLANTATION; PAIN; PHYSICAL EXAMINATION; PREDICTIVE VALUE; PRIORITY JOURNAL; QUESTIONNAIRE; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SKIN BIOPSY; SKIN CARCINOMA; SKIN DEFECT; TUMOR BIOPSY; TUMOR INVASION; VISUAL ANALOG SCALE;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; ORGAN TRANSPLANTATION; PAIN; PROGNOSIS; QUESTIONNAIRES; RISK FACTORS; SKIN NEOPLASMS;

EID: 84896707542     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12587     Document Type: Article

References (29)

1. Euvrard S, Kanitakis J, Claudy A. Skin cancers after organ transplantation. N Engl J Med 2003; 348: 1681-1691.
2. Euvrard S, Kanitakis J, Decullier E, et al. Subsequent skin cancers in kidney and heart transplant recipients after the first squamous cell carcinoma. Transplantation 2006; 81: 1093-1100.
3. Hartevelt MM, Bouwes Bavinck JN, Kootte AM, Vermeer BJ, Vandenbroucke JP. Incidence of skin cancer after renal transplantation in The Netherlands. Transplantation 1990; 49: 506-509.
4. Ramsay HM, Reece SM, Fryer AA, Smith AG, Harden PN. Sevenyear prospective study of nonmelanoma skin cancer incidence in U.K. renal transplant recipients. Transplantation 2007; 84: 437-439.
5. Vajdic CM, McDonald SP, McCredie MR, et al. Cancer incidence before and after kidney transplantation. JAMA 2006; 296: 2823-2831.
6. Villeneuve PJ, Schaubel DE, Fenton SS, et al. Cancer incidence among Canadian kidney transplant recipients. Am J Transplant 2007; 7: 941-948.
7. Wisgerhof HC, Edelbroek JR, de Fijter JW, et al. Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: Cumulative incidence and risk factors. Transplantation 2010; 89: 1231-1238.
8. Wisgerhof HC, van der Geest LG, de Fijter JW, et al. Incidence of cancer in kidney-transplant recipients: A long-term cohort study in a single center. Cancer Epidemiol 2011; 35: 105-111.
9. Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001; 344: 975-983.
10. Marks R. Squamous cell carcinoma. Lancet 1996; 347: 735-738.
11. Harwood CA, Mesher D, McGregor JM, et al. A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population. Am J Transplant 2013; 13: 119-129.
12. Krynitz B, Edgren G, Lindelof B, et al. Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008 - A Swedish population-based study. Int J Cancer 2013; 132: 1429-1438.
13. Bouwes Bavinck JN, Euvrard S, Naldi L, et al. Keratotic skin lesions and other risk factors are associated with skin cancer in organtransplant recipients: A case-control study in The Netherlands, United Kingdom, Germany, France, and Italy. J Invest Dermatol 2007; 127: 1647-1656.
14. Cook BA, Gravely AA, Nelson DB, Warshaw EM. Is tenderness a reliable predictor for differentiating squamous cell carcinomas from actinic keratoses? J Am Acad Dermatol 2011; 65: 211-212.
15. Kwatra SG, Mills KC, Zeitany A, et al. Pain and nonmelanoma skin cancer in transplant patients. J AmAcad Dermatol 2012; 67: 1387-1388.
16. Mills KC, Kwatra SG, Feneran AN, et al. Itch and pain in nonmelanoma skin cancer: Pain as an important feature of cutaneous squamous cell carcinoma. Arch Dermatol 2012; 148: 1422-1423.
17. Akobeng AK. Understanding diagnostic tests 3: Receiver operating characteristic curves. Acta Paediatr 2007; 96: 644-647.
18. Askari SK, Schram SE, Wenner RA, et al. Evaluation of prospectively collected presenting signs/symptoms of biopsyproven melanoma, basal cell carcinoma, squamous cell carcinoma, and seborrheic keratosis in an elderly male population. J Am Acad Dermatol 2007; 56: 739-747.
19. Viken J, Bendtsen L, Hansen K, et al. Facial pain and multiple cranial palsies in a patient with skin cancer. J Headache Pain 2011; 12: 381-383.
20. Liu Q, Tang Z, Surdenikova L, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 2009; 139: 1353-1365.
21. Steinhoff M, Bienenstock J, Schmelz M, et al. Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus. J Invest Dermatol 2006; 126: 1705-1718.
22. Tominaga M, Kamo A, Tengara S, Ogawa H, Takamori K. In vitro model for penetration of sensory nerve fibres on a Matrigel basement membrane: Implications for possible application to intractable pruritus. Br J Dermatol 2009; 161: 1028-1037.
23. Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M. The neurobiology of itch. Nat Rev Neurosci 2006; 7: 535-547.
24. Dziunycz P, Hofbauer GF. Immune phenotype of peripheral blood cells and skin squamous cell carcinoma in organ transplant recipients. Expert Rev Clin Immunol 2010; 6: 359-362.
25. Dawes JM, Calvo M, Perkins JR, et al. CXCL5 mediates UVB irradiation-induced pain. Sci Transl Med 2011; 3: 90ra60.
26. Nobbe S, Dziunycz P, Muhleisen B, et al. IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis. Acta Derm Venereol 2012; 92: 24-28.
27. Bolotin D, Petronic-Rosic V. Dermatitis herpetiformis. Part I. Epidemiology, pathogenesis, and clinical presentation. J Am Acad Dermatol 2011; 64: 1017-1024.
28. Muhleisen B, Petrov I, Gachter T, et al. Progression of cutaneous squamous cell carcinomain immunosuppressed patients is associated with reduced CD123+ and FOXP3+ cells in the perineoplastic inflammatory infiltrate. Histopathology 2009; 55: 67-76.
29. Kosmidis M, Dziunycz P, Suarez-Farinas M, et al. Immunosuppression affects CD4+ mRNA expression and induces Th2 dominance in the microenvironment of cutaneous squamous cell carcinoma in organ transplant recipients. J Immunother 2010; 33: 538-546.