Ulinastatin preconditioning attenuates inflammatory reaction of hepatic ischemia reperfusion injury in rats via high mobility group box 1(HMGB1) inhibition

International Journal of Medical Sciences

Volumn 11, Issue 4, 2014, Pages 337-343

  Tong, Ying ^a   Tang, Zhaohui ^a   Yang, Tian ^b   Yang, Yuting ^b   Yang, Liqun ^b   Shen, Weixing ^c   Chen, Weixin ^c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

High mobility group box 1 protein (HMGB1); Ischemia reperfusion; Preconditioning; Ulinastatin

Indexed keywords

AMINOTRANSFERASE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1; MYELOPEROXIDASE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HISTOPATHOLOGY; ISCHEMIC PRECONDITIONING; LIVER ISCHEMIA; LIVER LEVEL; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

HIGH MOBILITY GROUP BOX 1 PROTEIN (HMGB1); ISCHEMIA REPERFUSION; PRECONDITIONING; ULINASTATIN;

ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; CYTOKINES; GLYCOPROTEINS; HMGB1 PROTEIN; IMMUNOHISTOCHEMISTRY; LIVER; MALE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TRANSAMINASES; TRYPSIN INHIBITORS;

EID: 84896704594     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.7861     Document Type: Article

References (29)

1. Aihara T, Shiraishi M, Hiroyasu S, Hatsuse K, Mochizuki H, Seki S, et al. Ulinastatin, a protease inhibitor, attenuates hepatic ischemia/reperfusion injury by downregulating TNF-alpha in the liver. Transplant Proc. 1998; 30: 3732-4. doi:S0041-1345(98)01214-7 [pii].
2. Yang YL, Li JP, Xu XP, Dou KF, Yue SQ, Li KZ. Protective effects of tumor necrosis factor alpha antibody and ulinastatin on liver ischemic reperfusion in rats. World J Gastroenterol. 2004; 10: 3161-4.
3. Klune JR, Dhupar R, Cardinal J, Billiar TR, Tsung A. HMGB1: endogenous danger signaling. Mol Med. 2008; 14: 476-84. doi:10.2119/2008-00034.Klune.
4. Kang R, Livesey KM, Zeh HJ, 3rd, Lotze MT, Tang D. HMGB1 as an autophagy sensor in oxidative stress. Autophagy. 2011; 7: 904-6. doi:15704 [pii].
5. Fan J, Li Y, Levy RM, Fan JJ, Hackam DJ, Vodovotz Y, et al. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol. 2007; 178: 6573-80.
6. Tang D, Shi Y, Kang R, Li T, Xiao W, Wang H, et al. Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. J Leukoc Biol. 2007; 81: 741-7. doi:10.1189/jlb.0806540.
7. Serafin A, Rosello-Catafau J, Prats N, Gelpi E, Rodes J, Peralta C. Ischemic preconditioning affects interleukin release in fatty livers of rats undergoing ischemia/reperfusion. Hepatology. 2004; 39: 688-98. doi:10.1002/hep.20089.
8. Tsung A, Sahai R, Tanaka H, Nakao A, Fink M, Lotze M, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med. 2005; 201: 1135-43. doi:10.1084/jem.20042614.
9. Tanaka R, Fujita M, Tsuruta R, Fujimoto K, Aki HS, Kumagai K, et al. Urinary trypsin inhibitor suppresses excessive generation of superoxide anion radical, systemic inflammation, oxidative stress, and endothelial injury in endotoxemic rats. Inflamm Res. 2010; 59: 597-606. doi:10.1007/s00011-010-0166-8.
10. Wobbes T, Bemelmans BL, Kuypers JH, Beerthuizen GI, Theeuwes AG. Risk of postoperative septic complications after abdominal surgical treatment in relation to perioperative blood transfusion. Surg Gynecol Obstet. 1990; 171: 59-62.
11. Cowan RE, Jackson BT, Grainger SL, Thompson RP. Effects of anesthetic agents and abdominal surgery on liver blood flow. Hepatology. 1991; 14: 1161-6.
12. Bahde R, Spiegel H. Hepatic ischaemia-reperfusion injury from bench to bedside. Br J Surg. 2010; 97: 1461-75. doi:10.1002/bjs.7176.
13. Ding Y, Kantarci A, Hasturk H, Trackman PC, Malabanan A, Van Dyke TE. Activation of RAGE induces elevated O2-generation by mononuclear phagocytes in diabetes. J Leukoc Biol. 2007; 81: 520-7. doi:10.1189/jlb.0406262.
14. Victor VM, Rocha M, De la Fuente M. Immune cells: free radicals and antioxidants in sepsis. Int Immunopharmacol. 2004; 4: 327-47. doi:10.1016/j.intimp.2004.01.020.
15. Tsung A, Klune J, Zhang X, Jeyabalan G, Cao Z, Peng X, et al. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med. 2007; 204: 2913-23. doi:10.1084/jem.20070247.
16. Nishijima J, Hiraoka N, Murata A, Oka Y, Kitagawa K, Tanaka N, et al. Protease inhibitors (gebexate mesylate and ulinastatin) stimulate intracellular chemiluminescence in human neutrophils. J Leukoc Biol. 1992; 52: 262-8.
17. Kudo Y, Egashira T, Yamanaka Y. Protective effect of ulinastatin against liver injury caused by ischemia-reperfusion in rats. Jpn J Pharmacol. 1992; 60: 239-45.
18. Wunder C, Potter RF. The heme oxygenase system: its role in liver inflammation. Curr Drug Targets Cardiovasc Haematol Disord. 2003; 3: 199-208.
19. Alcaraz MJ, Fernandez P, Guillen MI. Anti-inflammatory actions of the heme oxygenase-1 pathway. Curr Pharm Des. 2003; 9: 2541-51.
20. Soares MP, Brouard S, Smith RN, Bach FH. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol Rev. 2001; 184: 275-85.
21. Wagener FA, Volk HD, Willis D, Abraham NG, Soares MP, Adema GJ, et al. Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev. 2003; 55: 551-71. doi:10.1124/pr.55.3.5.
22. Hatada T, Wada H, Nobori T, Okabayashi K, Maruyama K, Abe Y, et al. Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation. Thromb Haemost. 2005; 94: 975-9. doi:10.1160/TH05-05-0316.
23. Ito T, Kawahara K, Nakamura T, Yamada S, Abeyama K, Hashiguchi T, et al. High-mobility group box 1 protein promotes development of microvascular thrombosis in rats. J Thromb Haemost. 2007; 5: 109-16. doi:10.1111/j.1538-7836.2006.02255.x.
24. Mabuchi A, Wake K, Marlini M, Watanabe H, Wheatley AM. Protection by glycyrrhizin against warm ischemia-reperfusion-induced cellular injury and derangement of the microcirculatory blood flow in the rat liver. Microcirculation. 2009; 16: 364-76. doi:10.1080/10739680902796917.
25. Hatano E. Tumor necrosis factor signaling in hepatocyte apoptosis. J Gastroenterol Hepatol. 2007; 22 Suppl 1: S43-4. doi:10.1111/j.1440-1746.2006.04645.x.
26. Tang D, Kang R, Livesey KM, Zeh HJ, Lotze MT. High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress. Antioxid Redox Signal. 2011. doi:10.1089/ars.2010.3666.
27. Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene. 1999; 18: 6853-66. doi:10.1038/sj.onc.1203239.
28. Izuishi K, Tsung A, Jeyabalan G, Critchlow ND, Li J, Tracey KJ, et al. Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol. 2006; 176: 7154-8.
29. Greisman SE, Young EJ, Carozza FA, Jr. Mechanisms of endotoxin tolerance. V. Specificity of the early and late phases of pyrogenic tolerance. J Immunol. 1969; 103: 1223-36.