Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress

Medical Hypotheses

Volumn 82, Issue 4, 2014, Pages 503-

  Brenner, Steven ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CHELATING AGENT; HYDROGEN; MELANIN; OXIDOPAMINE; OXYGEN; WATER;

BRAIN PROTECTION; BRAIN WATER; CEREBROSPINAL FLUID; DETERIORATION; DISSOCIATION; LETTER; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; STRIATONIGRAL DEGENERATION; SUBSTANTIA NIGRA;

ANIMALS; ANTIOXIDANTS; BRAIN; CALORIMETRY; HUMANS; HYDROGEN; MELANINS; OXIDATIVE STRESS; PARKINSON DISEASE; SUBSTANTIA NIGRA; WATER;

EID: 84896703834     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2014.01.013     Document Type: Letter

References (4)

1. Solis Arturo, Lara Maria, Rendon Luis. Photoelectrochemical properties of melanin; 2007. Available from Nature Precedings. http://www.hdl.handle.net/10101/npre.2007.1312.1.
2. Powell M.R., Rosenberg B. The nature of the charge carriers in biomacromolecules. Bioenergetics 1970, 1:493-509.
3. Fu Y., Ito M., Fujita Y., Ito M., Ichihara M., Masuda A., et al. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett 2009, 453:81-85.
4. Fujita K., Seike T., Yusudo N., Ohno M., Yamada H., Yamaguchi H., et al. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinsons's disease. Plos One 2009, 4:e7247.