Individualised pelvic floor muscle training in women with pelvic organ prolapse (POPPY): A multicentre randomized controlled trial

The Lancet

Volumn 383, Issue 9919, 2014, Pages 796-806

  Hagen, Suzanne ^a   Stark, Diane ^b   Glazener, Cathryn ^c   Dickson, Sylvia ^a   Barry, Sarah ^d   Elders, Andrew ^c   Frawley, Helena ^e   Galea, Mary P ^f   Logan, Janet ^a   McDonald, Alison ^c   McPherson, Gladys ^c   Moore, Kate H ^g   Norrie, John ^c   Walker, Andrew ^d   Wilson, Don ^h  

^a GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e THE UNIVERSITY OF MELBOURNE   (Australia)

^f UNIVERSITY OF MELBOURNE   (Australia)

^g ST GEORGE HOSPITAL   (Australia)

^h UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL PAIN; ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BACKACHE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DATA ANALYSIS; DISEASE SEVERITY; FEMALE; FOLLOW UP; GYNECOLOGIST; HUMAN; INTENTION TO TREAT ANALYSIS; LIFESTYLE; MAJOR CLINICAL STUDY; MIDDLE AGED; MULTICENTER STUDY; PELVIC FLOOR MUSCLE TRAINING; PELVIC ORGAN PROLAPSE; PERSONALIZED MEDICINE; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM;

AMBULATORY CARE; EXERCISE THERAPY; FEMALE; HUMANS; INDIVIDUALIZED MEDICINE; MIDDLE AGED; PELVIC FLOOR; PELVIC ORGAN PROLAPSE; TREATMENT OUTCOME;

EID: 84896701011     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(13)61977-7     Document Type: Article

References (39)

1. Hendrix SL, Clark A, Nygaard I, Aragaki A, Barnabei V, McTiernan A. Pelvic organ prolapse in the Women's Health Initiative: gravity and gravidity. Am J Obstet Gynecol 2002; 186: 1160-66.
2. Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 1997; 89: 501-06.
3. Health and Social Care Information Centre. Hospital episode statistics, admitted patient care-England, 2010-11. Nov 2, 2011. http://www.hscic.gov.uk/ pubs/hesadmitted1011 (accessed June 22, 2013).
4. Wu JM, Kawasaki A, Hundley AF, Dieter AA, Myers ER, Sung VW. Predicting the number of women who will undergo incontinence and prolapse surgery, 2010 to 2050. Am J Obstet Gynecol 2011; 205: 230.e1-5.
5. Miedel A, Tegerstedt G, Maehle-Schmidt M, Nyren O, Hammarstrom M. Nonobstetric risk factors for symptomatic pelvic organ prolapse. Obstet Gynecol 2009; 113: 1089-97.
6. Slieker-ten Hove MC, Pool-Goudzwaard AL, Eijkemans MJ, Steegers-Theunissen RP, Burger CW, Vierhout ME. Symptomatic pelvic organ prolapse and possible risk factors in a general population. Am J Obstet Gynecol 2009; 200: 184.e1-7.
7. Abrams PH, Cardoza L, Khoury AE, Wein A. Incontinence, 5th edn. Plymbridge, UK: Health Publication Ltd, 2013.
8. Hagen S, Stark D, Cattermole D. A United Kingdom-wide survey of physiotherapy practice in the treatment of pelvic organ prolapse. Physiotherapy 2004; 90: 19-26.
9. Dumoulin C, Hay-Smith J. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database Syst Rev 2010; 1: CD005654.
10. Hagen S, Stark D. Conservative prevention and management of pelvic organ prolapse in women. Cochrane Database Syst Rev 2011; 12: CD003882.
11. Bump RC, Mattiasson A, Bo K, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 1996; 175: 10-17.
12. Hagen S, Stark D, Glazener C, Sinclair L, Ramsay I. A randomized controlled trial of pelvic floor muscle training for stages I and II pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct 2009; 20: 45-51.
13. Bo K. Pelvic floor muscle exercise for the treatment of stress urinary incontinence: an exercise physiology perspective. Int Urogynecol J 1995; 6: 282-91.
14. National Institute for Health and Clinical Excellence. Urinary incontinence: the management of urinary incontinence in women. Clinical guidance 40. London: NICE, 2006.
15. Laycock J, Jerwood D. Pelvic floor muscle assessment: the PERFECT scheme. Physiotherapy 2001; 87: 631-42.
16. Hagen S, Glazener C, Sinclair L, Stark D, Bugge C. Psychometric properties of the pelvic organ prolapse symptom score. BJOG 2009; 116: 25-31.
17. Avery K, Donovan J, Peters TJ, Shaw C, Gotoh M, Abrams P. ICIQ: a brief and robust measure for evaluating the symptoms and impact of urinary incontinence. Neurourol Urodyn 2004; 23: 322-30.
18. Rogers RG, Coates KW, Kammerer-Doak D, Khalsa S, Qualls C. A short form of the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12). Int Urogynecol J Pelvic Floor Dysfunct 2003; 14: 164-68.
19. Ware JE Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996; 34: 220-33.
20. Allahdin S, Glazener C, Bain C. A randomised controlled trial evaluating the use of polyglactin mesh, polydioxanone and polyglactin sutures for pelvic organ prolapse surgery. J Obstet Gynaecol 2008; 28: 427-31.
21. Diggle PJ, Heagerty P, Liang K-Y, Zeger SL. Analysis of longitudinal data, 2nd edn. Clarendon: Oxford University Press Inc, 2002.
22. Rubin DB. Multiple imputation for nonresponse in surveys. New York: John Wiley & Sons, 1987.
23. R Development Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing, 2012.
24. Su Y-S, Gelman A, Hill J, Yajima M. Multiple imputation with diagnostics (mi) in R: opening windows into the black box. J Stat Softw 2011; 45: 1-31.
25. Curtis L. Unit costs of health and social care 2009. Kent: University of Kent, 2009.
26. Information Services Division. Scottish health service costs year ended 31 March 2010. Edinburgh: NHS National Services Scotland, 2010.
27. Joint Formulary Committee. British National Formulary, 61st edn. London: British Medical Association and Royal Pharmaceutical Society of Great Britain, 2011.
28. C&G Medicare. Club pessary. 2010. http://www.incoshop.co.uk/club- pessary-238-p.asp/ (accessed June 25, 2012).
29. Hagen S, Glazener C, Cook J, Herbison P, Toozs-Hobson P. Further properties of the pelvic organ prolapse symptom score: minimally important change and test-retest reliability. Neurourol Urodyn 2010; 29: 1055-56.
30. Ghroubi S, Kharrat O, Chaari M, Ben Ayed B, Guermazi M, Elleuch MH. Effect of conservative treatment in the management of low-degree urogenital prolapse. Ann Readapt Med Phys 2008; 51: 96-102 (in French).
31. Stupp L, Resende AP, Oliveira E, Castro RA, Girao MJ, Sartori MG. Pelvic floor muscle training for treatment of pelvic organ prolapse: an assessor-blinded randomized controlled trial. Int Urogynecol J 2011; 22: 1233-39.
32. Piya-Anant M, Therasakvichya S, Leelaphatanadit C, Techatrisak K. Integrated health research program for the Thai elderly: prevalence of genital prolapse and effectiveness of pelvic floor exercise to prevent worsening of genital prolapse in elderly women. J Med Assoc Thai 2003; 86: 509-15.
33. Brakken IH, Majida M, Engh ME, Bo K. Can pelvic floor muscle training reverse pelvic organ prolapse and reduce prolapse symptoms? An assessor-blinded, randomized, controlled trial. Am J Obstet Gynecol 2010; 203: 170e1-7.
34. Kashyap R, Jain V, Singh A. Comparative effect of 2 packages of pelvic floor muscle training on the clinical course of stage I-III pelvic organ prolapse. Int J Gynaecol Obstet 2013; 121: 69-73.
35. Ellerkmann RM, Cundiff GW, Melick CF, Nihira MA, Leffler K, Bent AE. Correlation of symptoms with location and severity of pelvic organ prolapse. Am J Obstet Gynecol 2001; 185: 1332-37.
36. Mouritsen L, Larsen JP. Symptoms, bother and POPQ in women referred with pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct 2003; 14: 122-27.
37. Handa VL, Garrett E, Hendrix S, Gold E, Robbins J. Progression and remission of pelvic organ prolapse: a longitudinal study of menopausal women. Am J Obstet Gynecol 2004; 190: 27-32.
38. Bradley CS, Zimmerman MB, Qi Y, Nygaard IE. Natural history of pelvic organ prolapse in postmenopausal women. Obstet Gynecol 2007; 109: 848-54.
39. Miedel A, Ek M, Tegerstedt G, Mahle-Schmidt M, Nyren O, Hammarstrom M. Short-term natural history in women with symptoms indicative of pelvic organ prolapse. Int Urogynecol J 2011; 22: 461-68.